general population: changing prevalence and age distribution Circulation 2007;115:163–172 46 Gatzoulis MA, Hechter S, Siu SC, Webb GD Outpatient clinics for adults with congenital heart disease: increasing workload and evolving patterns of referral Heart 1999;81:57–61 47 Marelli AJ, Mackie AS, Ionescu-Ittu R, Rahme E, Pilote L Congenital heart disease in the general population: changing prevalence and age distribution Circulation 2007;115:163–172 48 Engelfriet P, Boersma E, Oechslin E, et al The spectrum of adult congenital heart disease in Europe: morbidity and mortality in a 5 year follow-up period The Euro Heart Survey on adult congenital heart disease Eur Heart J 2005;26:2325–2333 [SRC - GoogleScholar] 49 Gilboa SM, Devine OJ, Kucik JE, et al Congenital heart defects in the United States: estimating the magnitude of the affected population in 2010 Circulation 2016;134:101– 109 50 Mackie AS, Pilote L, Ionescu-Ittu R, Rahme E, Marelli AJ Health care resource utilization in adults with congenital heart disease Am J Cardiol 2007;99:839–843 [SRC GoogleScholar] 51 Moons P, Siebens K, De Geest S, et al A pilot study of expenditures on, and utilization of resources in, health care in adults with congenital heart disease Cardiol Young 2001;11:301–313 52 Lenke RR, Levy HL Maternal phenylketonuria and hyperphenylalaninemia An international survey of the outcome of untreated and treated pregnancies N Engl J Med 1980;303:1202– 1208 53 Levy HL, Guldberg P, Guttler F, et al Congenital heart disease in maternal phenylketonuria: report from the Maternal PKU Collaborative Study Pediatr Res 2001;49:636–642 54 Matalon KM, Acosta PB, Azen C Role of nutrition in pregnancy with phenylketonuria and birth defects Pediatrics 2003;112:1534–1536 55 Rouse B, Azen C Effect of high maternal blood phenylalanine on offspring congenital anomalies and developmental outcome at ages 4 and 6 years: the importance of strict dietary control preconception and throughout pregnancy J Pediatr 2004;144:235–239 56 Ferencz C, Loffredo CA, Correa-Villasenor A, Wilson PD Genetic and Environmental Risk Factors of Major Cardiovascular Malformations: The Baltimore-Washington Infant Study Futura Publishing Company Inc: Armonk, NY; 1997:1981–1989 57 Ramos-Arroyo MA, Rodriguez-Pinilla E, Cordero JF Maternal diabetes: the risk for specific birth defects Eur J Epidemiol 1992;8:503–508 58 Becerra JE, Khoury MJ, Cordero JF, Erickson JD Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study Pediatrics 1990;85:1–9 59 Bower C, Stanley F, Connell AF, Gent CR, Massey MS Birth defects in the infants of aboriginal and non-aboriginal mothers with diabetes in Western Australia Med J Aust 1992;156:520–524 60 Botto LD, Erickson JD, Mulinare J, Lynberg MC, Liu Y Maternal fever, multivitamin use, and selected birth defects: evidence of interaction? Epidemiology 2002;13:485–488 61 Tikkanen J, Heinonen OP Maternal hyperthermia during pregnancy and cardiovascular malformations in the offspring Eur J Epidemiol 1991;7:628–635 62 Zhang J, Cai WW Association of the common cold in the first trimester of pregnancy with birth defects Pediatrics 1993;92:559–563 63 Scanlon KS, Ferencz C, Loffredo CA, et al Preconceptional folate intake and malformations ... Matalon KM, Acosta PB, Azen C Role of nutrition in pregnancy with phenylketonuria and birth defects Pediatrics 2003;112:1534–1536 55 Rouse B, Azen C Effect of high maternal blood phenylalanine on offspring congenital anomalies... Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study Pediatrics 1990;85:1–9 59 Bower C, Stanley F, Connell AF, Gent CR, Massey MS Birth defects in the infants of... Zhang J, Cai WW Association of the common cold in the first trimester of pregnancy with birth defects Pediatrics 1993;92:559–563 63 Scanlon KS, Ferencz C, Loffredo CA, et al Preconceptional folate intake and malformations