Methemoglobinemia Cortazzo JA, Lichtman AD Methemoglobinemia: a review and recommendations for management J Cardiothorac Vasc Anesth 2014;28:1055–1059 Wright RO, Lewander WJ, Woolf AD Methemoglobinemia: etiology, pharmacology, and clinical management Ann Emerg Med 1999;34:646–656 Sickle Cell Disease Baskin MN, Goh XL, Heeney MM, et al Bacteremia risk and outpatient management of febrile patients with sickle cell disease Pediatrics 2013;131:1035–1041 Field JJ, DeBaun MR Asthma and sickle cell disease: two distinct diseases or part of the same process? Hematology Am Soc Hematol Educ Program 2009:45–53 doi: 10.1182/asheducation-2009.1.45 Ogunlesi F, Heeney MM, Koumbourlis AC Systemic corticosteroids in acute chest syndrome: friend or foe? Paediatr Respir Rev 2014;15:24–27 Quinn CT Sickle cell disease in childhood: from newborn screening through transition to adult medical care Pediatr Clin North Am 2013;60:1363–1381 Rees DC, Williams TN, Gladwin MT Sickle-cell disease Lancet 2010;376:2018–2031 Venkataraman A, Adams RJ Neurologic complications of sickle cell disease Handb Clin Neurol 2014;120:1015–1025 Yee ME, Bakshi N, Graciaa SH, et al Incidence of invasive Haemophilus influenzae infections in children with sickle cell disease Pediatr Blood Cancer 2019;66:e27642 Neutropenia Boxer LA, Newburger PE A molecular classification of congenital neutropenia syndromes Pediatr Blood Cancer 2007;49:609–614 Dokal I, Vulliamy T Inherited aplastic anaemias/bone marrow failure syndromes Blood Rev 2008;22:141–153 Newburger PE, Dale DC Evaluation and management of patients with isolated neutropenia Semin Hematol 2013;50:198–206 Immune Thrombocytopenia Buchanan GR, Adix L Grading of hemorrhage in children with idiopathic thrombocytopenic purpura J Pediatr 2002;141:683–688 Labarque V, Van Geet C Clinical practice: immune thrombocytopenia in paediatrics Eur J Pediatr 2014;173:163–172 Neunert CE, Buchanan GR, Imbach P, et al; Intercontinental Childhood ITP Study Group Registry II Participants Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura Blood 2008;112:4003–4008 Neunert C, Lim W, Crowther M, et al; American Society of Hematology The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia Blood 2011;117:4190–4207 Other Disorders Associated With Thrombocytopenia Balduini CL, Pecci A, Noris P Diagnosis and management of inherited thrombocytopenias Semin Thromb Hemost 2013;39:161–171 Bertrand G, Kaplan C How we treat fetal and neonatal alloimmune thrombocytopenia? Transfusion 2014;54:1698–1703 Warkentin TE, Linkins LA Non-necrotizing heparin-induced skin lesions and the 4T’s score J Thromb Haemost 2010;8:1483–1485 Thrombocytosis Bleeker JS, Hogan WJ Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies Thrombosis 2011:1–16 Fu R, Zhang L, Yang R Paediatric essential thrombocythaemia: clinical and molecular features, diagnosis and treatment Br J Haematol 2013;163:295–302 Schafer AI Thrombocytosis and thrombocythemia Blood Rev 2001;15:159–166 Teofili L, Larocca LM Advances in understanding the pathogenesis of familial thrombocythaemia Br J Haematol 2011;152:701–712 Disorders of Hemostasis Al-Samkari H, Croteau SE Shifting current clinical coagulation assays Am J Hematol 2018;93:1082–1090 Lee LK, Dayan PS, Gerardi MJ, et al; Traumatic Brain Injury Study Group for the Pediatric Emergency Care Applied Research Network (PECARN) Intracranial hemorrhage after blunt head trauma in children with bleeding disorders J Pediatr 2011;158:1003–1008.e1–e2 Sarnaik A, Kamat D, Kannikeswaran N Diagnosis and management of bleeding disorder in a child Clin Pediatr (Phila) 2010;49:422–431 Sharma R, Flood VH Advances in the diagnosis and treatment of von Willebrand disease Blood 2017;130(22):2386–2391 Singleton T, Kruse-Jarres R, Leissinger C Emergency department care for patients with hemophilia and von Willebrand disease J Emerg Med 2010;39:158–165 Hypercoaguability Andrew M, Marzinotto V, Massicotte P, et al Heparin therapy in pediatric patients: a prospective cohort study Pediatr Res 1994;35:78–83 Monagle P, Chan AK, Goldenberg NA, et al; American College of Chest Physicians Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians EvidenceBased Clinical Practice Guidelines Chest 2012;141:e737S–e801S Monagle P, Newall F Management of thrombosis in children and neonates: practical use of anticoagulants in children Hematology Am Soc Hematol Educ Program 2018;2018(1):399–404 Nowak-Göttl U, van Ommen H, Kenet G Thrombophilia testing in children: what and when should be tested? Thromb Res 2018;164:75–78 Roach ES, Golomb MR, Adams R, et al; American Heart Association Stroke Council; Council on Cardiovascular Disease in the Young Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young Stroke 2008;39:2644–2691 Young G How I treat pediatric venous thromboembolism Blood 2017;130(12):1402– 1408 Transfusion Reactions Osterman JL, Arora S Blood product transfusions and reactions Emerg Med Clin North Am 2014;32:727–738 CHAPTER 94 ■ INFECTIOUS DISEASE EMERGENCIES ANDREA T CRUZ GOALS OF EMERGENCY CARE Fever is one of the most common presenting complaints for children seen in the emergency department (ED) ED physicians face the challenge of differentiating potentially life-, limb-, or sensory-threatening causes of infection from the vast majority of children with febrile illnesses that will spontaneously resolve without intervention For infectious disease (ID) emergencies, the clinical evaluation should focus upon prompt recognition of potentially serious conditions Evidence-based diagnostic strategies can facilitate care and avoid unnecessary evaluations of otherwise well-appearing children RELATED CHAPTERS Signs and Symptoms Diarrhea: Chapter 23 Fever: Chapter 31 Lymphadenopathy: Chapter 47 Neck Mass: Chapter 48 Oral Lesions: Chapter 52 Septic-Appearing Infant: Chapter 73 Sore Throat: Chapter 74 Tachycardia: Chapter 77 Medical, Surgical, and Trauma Emergencies Cardiac Emergencies: Chapter 86 Gastrointestinal Emergencies: Chapter 91 Gynecology Emergencies: Chapter 92 Oncologic Emergencies: Chapter 98 BACTEREMIA AND SEPSIS CLINICAL PEARLS AND PITFALLS It can be difficult to differentiate among children with uncomplicated viral infections and occult bacteremia With reduction in vaccine-preventable diseases, most positive blood cultures are false positive with contaminants Evidence-based guidelines can optimize management in the young febrile child Current Evidence The epidemiology of pediatric bacteremia has changed dramatically over the last three decades due to widespread use of the 13-valent pneumococcal conjugate and Haemophilus influenzae type B (Hib) vaccines The most common isolates now causing bacteremia are listed in Table 94.1 While rates of pneumococcal bacteremia have declined in the post-pneumococcal conjugate vaccine era, Streptococcus pneumoniae still comprises most cases of bacteremia, along with Staphylococcus aureus, Salmonella, group A streptococcus (GAS), and meningococcus; group B streptococcus (GBS) and gram-negative rods remain the most common causes of bacteremia and sepsis in neonates and young infants In some studies, contaminants are up to sevenfold more common than true pathogens As a consequence, use of evidence-based algorithms in the approach to the febrile child (Chapter 31 Fever ) can reduce unnecessary evaluation and optimize treatment of the well-appearing child ... 2018;93:1082–1090 Lee LK, Dayan PS, Gerardi MJ, et al; Traumatic Brain Injury Study Group for the Pediatric Emergency Care Applied Research Network (PECARN) Intracranial hemorrhage after blunt head trauma... INFECTIOUS DISEASE EMERGENCIES ANDREA T CRUZ GOALS OF EMERGENCY CARE Fever is one of the most common presenting complaints for children seen in the emergency department (ED) ED physicians face the... 2010;39:158–165 Hypercoaguability Andrew M, Marzinotto V, Massicotte P, et al Heparin therapy in pediatric patients: a prospective cohort study Pediatr Res 1994;35:78–83 Monagle P, Chan AK, Goldenberg