Nicardipine is a second-generation dihydropyridine calcium channel blocker that prevents vascular smooth muscle contraction, resulting in a reduction in peripheral vascular resistance without compromising cardiac output Its onset of action within to minutes of administration and short elimination half-life make it relatively easy to titrate Nicardipine is the preferred agent for the treatment of hypertensive emergencies at many institutions because of its safety profile, ability to produce a rapid effect, and low risk for causing hypotension Recommended dosing is to μg/kg/min by continuous infusion Hypotension, though uncommon, can be reversed by the administration of calcium Nicardipine should be avoided in patients with increased intracranial pressure Reflex tachycardia, usually clinically insignificant, and phlebitis are known adverse effects