Report on the Under-Treatment of Pain in Victims Injured in the 2008 Wenchuan Earthquake and its Implications for Future Emergencies

Report on the Under-Treatment of Pain in Victims Injured in the 2008 Wenchuan Earthquake and its Implications for Future Emergencies Short Title: Untreated Pain Following the Wenchuan Earthquake Hong Xiao, MD1, Yun-Xia Zuo, MD, PhD2, Bang-Xiang Yang, MD3,Li Song , MD4, Chuan-Bing Wen, MD5,Yue-E Dai, MD6, Hui YU, MD7, Li-Li Xu, MD8, Qiao Guo, MD9, Zhi-Ping Song, MD10, Ernest Volinn, PhD11, Jin Liu, MD12, and Hui Liu, MD13 Associate Professor, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Professor and Vice-Chairman of Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China 10 Anesthesia Resident, Attending Physician, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China 11 Research Associate Professor, Pain Research Center, School of Medicine, Department of Anesthesiology, University of Utah Corresponding authors: Hui Liu, MD Professor, Department of Anesthesiology West China Hospital Sichuan University Chengdu, Sichuan 610041, China Email: hongxiao@mcwcums.com Jin Liu, MD Professor and Chairman, Department of Anesthesiology West China Hospital Sichuan University Chengdu, Sichuan 610041, P.R China, Tel:+86-02885423591 Fax: +86-28-85423591 Email: huaximazui@yahoo.com.cn This work was supported by grant No 30872435 from the National Research Foundation of Nature Science, Beijing, China The authors declare no conflicts of interest ABSTRACT Background: On May 12, 2008, an earthquake measuring 8.0 on the Richter scale occurred in Wenchuan County, Sichuan Province, China Shortly afterwards, we interviewed some of the victims to investigate the physical pain they had suffered Our aim was to catalogue the physical pain associated with disasters of this magnitude and to provide an initial assessment of the general adequacy of treatment for pain Methods: We collected our data about five weeks after the earthquake Data on pain were collected from 848 victims, in ten different hospitals, and in shelter tents set up for the earthquake refugees in seven different towns near the epicenter of the earthquake Trained interviewers, speaking in the local dialect, conducted face-to-face interviews with these victims Results: The mean pain intensity was 6.6 ± 0.5, with the most intense being at the time of surgical debridement (VAS score 7.2 ± 2.1), and the lowest being before surgery in the wards (VAS score 6.1 ± 2.1) Victims with open bone fractures had more severe pain intensity than the other three types of injuries (VAS score 6.9±1.3) Very few victims received pain treatment (2.5% at the scene of injury, 1.6% at the time of rescue, 2.9% during debridement, 3.9% when transferred to the hospital, 19% in the hospital emergency department, 25% preoperatively in the surgical ward and 50% postoperatively) Only 60% of the patients who received postoperative analgesia were satisfied with their pain management Pain ratings did not vary according to gender, occupation, educational status, or hospital where treated Pain ratings were higher for patients older than 60 years than for younger patients Conclusions: The pain suffered by most of the victims was under-estimated and under- treated The high degree of pain in major disasters highlights the need for emergency preparedness, including local training on pain relief procedures, and the necessity for expeditious transport of pain relief supplies Emergency services, including both field and hospital medical teams, should be supplemented by professional pain physicians and a standard pain control regimen adopted for major disasters INTRODUCTION On May 12th, an earthquake measuring 8.0 on the Richter scale struck Wenchuan County, Sichuan Province, China It resulted in the deaths of 69,197 people, 374,176 injuries, and 18,222 missing individuals An estimated 4.8 million people lost their homes and became shelter refugees (1) Rescue operations and the emergency aid to the injured were obviously critical in a disaster of this magnitude (2-4) Prompt effective pain treatment, although also essential for the patients' physical and mental recovery (57), may have been lacking (8) Aside from acute pain experienced at the time of the disaster, under-treated pain may lead to lasting symptoms and debility, including chronic pain and posttraumatic stress disorder (PTSD) (9-13) For these reasons, in the immediate aftermath of the Wenchuan earthquake, we assembled a trained team in order to address the following questions: To what extent did injured patients experience physical pain? Did they receive analgesia commensurate with their pain? Among those injured, did demographic characteristics account for variations in the intensity of pain experienced? More generally, what is the role of pain physicians in rescue operations? METHODS Study design and data collection West China Hospital, an affiliate of Sichuan University, and local medical research ethics committees approved the study This was a retrospective investigation Data were collected for the study, which began about five weeks after the earthquake The study took place between June 22-September 7, 2008 Trained interviewers, speaking in the local dialect, conducted face-to-face interviews Interview Schedule The interview contained the three parts: 1) basic demographic variables (gender, age, address, educational level, and occupation), diagnosis of injuries, and hospital name; 2) Pain intensity (0 to 10 Visual Analogue Scale), and 3) the corresponding pain treatment and its effect Samples Patients were recruited from the following three locations: the local hospital, the rehabilitation hospital, and the shelter tents for the earthquake refugees While injured patients were in the hospital or shelter tents, interviewers approached physicians and collected data on patients’ diagnoses and pain treatment Patients were included if they were injured in the earthquake and consented to the interview Patients were excluded if they were unable to communicate in Mandarin or the local dialect, or were too disabled to communicate Patients were initially asked to respond to part of the interview Patients were assessed using parts and at seven points in time: the scene of the injury, when rescued, during surgical debridement, on transfer to the hospital, in the hospital emergency department, in the ward waiting for an operation, and during the postoperative period Instrument and key measures The intensity of pain was measured by ratings using 100 mm visual analogue scales (VAS), whose endpoints were anchored by (no pain) and 100 (cannot endure) Respondents were asked to place a mark along the scale to indicate their actual level of pain (“How intense was your pain?”) The effect of the analgesia was divided into five grades, anchored by grade (excellent analgesic effect) and grade (no analgesic effect) Earthquake injuries were summarized as fitting into four categories: soft tissue injury, closed bone fracture, open bone fracture, and multiple injuries The term ”multiple injuries”’ refers to a single cause leading to the injury of two or more organs RESULTS Demographic characteristics of the earthquake victims Eight hundred forty-eighty earthquake victims from seven towns near the epicenter of the earthquake were interviewed Their median age was 48 years Fifty-nine percent were 18-60 years old The range in ages was years to 102 years Patients were evenly divided among males (49%) and females (51%) Their occupations consisted of farmers (47%), students (13%), workers (9%), soldiers (1.3%) and others (9%) Thirteen percent were unemployed Seven percent had a university education, 15% and 26% had completed senior and junior school, respectively, and the other 52% had received less than a junior school education These earthquake victims suffered mainly from soft tissue injuries (20%), closed bone fractures (56%), open bone fractures (19%), and multiple injuries (4.6%) Pain intensity (VAS score) among the earthquake victims The pain intensity (VAS score) suffered by the 848 earthquake victims from the initial injury to the postoperative time was assessed by face-to- face interviews The mean pain intensity was 66 ± mm The highest VAS score at the time of surgical debridement in the field emergency aid areas was 72 ± 21 mm The lowest VAS score was 61 ± 21 mm, which was recorded in the surgical ward at the time of waiting for the operation The trend of pain intensity changes is shown in Figure Pain intensity was also analyzed according to the type of injury Victims with open bone fractures recorded a higher intensity of pain (VAS score 69 ± 13 mm) than those in the other three categories For soft tissue injuries, the mean pain intensity was 60 ± 12 mm Soft tissue injuries also had the highest pain intensity in the field at the time of surgical debridement (VAS score: 66 ± 21 mm) Although the patients reported less pain while waiting for surgery, it was still 55 ± 20 mm For closed bone fracture injuries the mean pain intensity was 68 ± 15 mm.The highest pain intensity was recorded at the scene of the injury, 73 ± 24 mm, and the lowest VAS score was immediately prior to surgery, 60 ± 20 mm For open bone fractures the mean VAS score was 69 ± 13 mm, with the highest pain intensity recorded in the field at the time of surgical debridement, 77 ± 19 mm During the postoperative period, the VAS score was 62 ± 24 m For multiple injuries, the mean VAS score was 63 ± 13 mm, while the highest score, recorded at the time of transfer to the hospital, was 67 ± 25 mm The lowest pain score, 58 ± 23 mm, occurred during the postoperative period Differences in VAS score were found among the various ages of patients Patients over 60 years old appeared to have higher pain intensity in all injury categories than the younger victims No significant differences in VAS scores were found in relation to gender, occupation, or educational status Loss family members or relatives from the earthquake did not influence pain intensity Pain intensities of those who were sent to small local hospitals did not differ from those who were sent to the tertiary hospitals, regardless of the different pain treatments they received Pain treatment and its effect on the earthquake victims Only 2.5% of the earthquake survivors received pain treatment (Table 1) at the time of injury Similarly, 1.6% received pain treatment when rescued, 2.9% at the time of surgical debridement, and 3.9% when transferred to the hospital After the victims were transferred to the hospital, their pain was also under-treated The percentage of victims who had pain treatment was only 19% when they were in the emergency departments of hospitals and 25% during the preoperative time in the surgical wards Only half of those who went to surgery received postoperative analgesia The primary analgesia for those who received anything was oral or intramuscular injection (Table 1) Tramadol and meperidine were the most commonly used medications In the hospital emergency departments, of the 18.9% of victims who received pain treatment, 38% were given tramadol, while 9% were given meperidine Of the 25% of patients who received pain treatment prior to surgery, 37% were treated with tramadol and 10% with meperidine For postoperative analgesia, the most commonly used prescription was also tramadol (27% of the patients) and meperidine (28% of patients) Patient-controlled analgesia was used in only 23% of the patients who received postoperative analgesia Nonsteroidal antiinflammatory drugs and morphine were also occasionally used for postoperative analgesic treatment Table summarizes the analgesics used Analgesia was not particularly effective in the few who did receive pain treatment We divided the analgesia effects into five grades as described in the Methods As shown in Table and Figure 2, half of the patients reported the analgesic effect as grade or (i.e little effect or no effect) at the time of rescue In addition, of those who received pain treatment at the time of transfer to the hospital, 30% reported the analgesic effect as grade or Of those receiving postoperatively analgesia, 60% reported the analgesic effect as grade or grade The analgesic effects of those who were sent to small local hospitals did not differ from those who were sent to the higher tertiary hospitals, regardless of the different pain treatments they received DISCUSSION The World Health Organization defines natural disaster as an ecological phenomenon of a sufficient magnitude to require external assistance (14) Disasters are inevitable and, as profound as its deleterious effects may have been, the Wenchuan earthquake did afford the opportunity to become better prepared for future disasters (15-18) In our investigation, the main findings were: Survivors frequently experienced moderate to severe pain from the time of the initial injury up to the end of the relief work after the earthquake Pain was under-recognized and under-treated throughout the entire period from the field rescue to the hospital treatment Survivors with open bone fractures had the most severe pain No significant differences in visual analog scale (VAS) scores were found in relation to gender, occupation, educational status, or hospital However, patients over 60 years old appeared to have more severe pain than younger patients for all categories of injuries, and bone fractions were more painful than the other types of injuries When a disaster occurs, saving lives is the overriding priority (19) However, this may be done at the expense of other needs, such as alleviating suffering (20,21) Pain is a conspicuous aspect of the suffering, even though it may be neglected in emergency situations The presumption may be that victims will ignore the pain, since all their attention is focused on staying alive, and on the injury itself (22) Nevertheless, according to our findings, earthquake survivors experienced severe pain from their injuries unmitigated by fear of loss of life Since many of the victims we interviewed did not receive any pain treatment, we are able to view the natural course of pain caused by this earthquake disaster The trend of the changes in the intensity of pain was shown in Figure The highest VAS score was at the time of surgical debridement in the field emergency aid areas The lowest VAS score was while waiting for surgery It was astonishing to see how the pain was neglected at the time of surgical debridement in the field emergency aid areas This indicated that the members of our first aid medical team focused their attention on the victims’ injury, but neglected treatment of pain The poor treatment of pain offered by the medical workers in the field may be due to the limitation of analgesic resources, though victims would expect to have better pain treatment in the hospital However, the pain of the survivors was also under-recognized and under-treated in the hospital A lack of awareness of the importance of pain control may have been coupled with an exaggerated fear of analgesic side effects Treatment of pain has been shown to be neglected in other disasters such as hurricanes (23) Therefore, more attention must be paid to pain management, and to the application of appropriate pain treatment at every stage from the initial field rescue to the hospital treatment, with particular emphasis on the field rescue stage It is strongly recommended that pain physicians be included in all future emergency relief teams to facilitate the immediate relief of the pain suffered by victims In our view, a team of professional pain treatment personnel should be formed and a standard pain control regimen established to better address future situations of this kind FIGURE LEGENDS Figure The pain intensity (visual analog scale score) of the patients throughout the entire relief work Timepoint 1= At the scene of the injury, 2= Being rescued, 3= Being debrided, 4= Being transferred, 5=The time patients were in the hospital emergency department, 6= Preoperative time, 7= Postoperative time Figure The analgesic effect of the investigated patients who received pain treatment Injury= At the scene of the injury, Rescued= at the time of being rescued, Debride= at the time of being debrided, Transferred=when being transferred, Emergency=The time of patients be in hospital Emergency, Preoperative= Preoperative time, Postoperative= Postoperative time ACKNOWLEDGMENT We are indebted to Professor Cheng-Qi He (Department of Rehabilitation, West China Hospital, Sichuan University) for assistance with the investigation, to Dr Zhao-Yang Hu (Department of Anesthesiology, West China Hospital, Sichuan University) for assistance with the preparation of the manuscript, and to Howard Stones for 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