Amenorrhea associated with bilateral polycystic ovaries ;•n;t 1 LEVE THAL JlllJAlh l~AL IOLYCYSTIC 0ARE S Jill concerned a squamous stratified epithelioma extending from a meta plastic fundal.Amenorrhea associated with bilateral polycystic ovaries ;•n;t 1 LEVE THAL JlllJAlh l~AL IOLYCYSTIC 0ARE S Jill concerned a squamous stratified epithelioma extending from a meta plastic fundal.
JlllJA'l'h:l~AL I'OLYCYSTIC 0\'AR!E.S :-;•n;t:-.1-LEVE.'\THAL: Jill concerned a squamous stratified epithelioma extending from a metaplastic fundal mucosa It was combined with a large submucous myoma (c) The third was an adenocarcinoma combined with a submucous myoma whieh had undergone changes into a polymorphous spindle-cell sarcoma REFERE.'\CF.S Cam.p: Ztschr f Geburtsh u, Gynak 10: 3i56, 1884 Cottt, M G.: Lyon Chir 28: 520, 1931 de Gery, Chastenet, and Perrot, Maur·ic.e: Ann rl 'Anat Path 9: 317, 1932 Ehrendorfer: Arch f Gyniik 42: 255, 1892 Frankl: An•h Gynak 95:: 269, 1910 Gutmann, M.: Monatschr f Geburtsh u Gyniik 89: 309, 1931 Jansen, H.: Monatsehr f Geburtsh u Gyniik 39: 207, 1914 Moeller, Ellis S.: Surg Gynec Obst 46: 187, 1928 Munroe Ken', Ji · Brit M J 1: 6!l, 1910 Newel, Q U.: AM ~f 0BS'r & GYNEC 17: ll!l, 1929 Piquand, G.: La Trib Med p 213, 1905 Piquand, Ann de Gynec 10: 393, 485, 565, 1905 Roberts, Hubert: Lancet 1: 454, 1917 Su.tton, Bland: J Obst & Gynec Brit Emp 10: 1, 1906 Undstroemer, Martin: Acta obst et gynee Scandinav 8: 112, 1929 Winter, G.: Ztschr f Geburtsh u Gynak 57: 8, Hl06 a.: AMENORRHEA ASSOCIATED WITH BILATERAL POLYCYSTIC OVARIES* IRVING F STEIN, M.D., AND MICHAEL L LEVE-NTHAL, M.D CHICAGO, ILL ! Fr&tn Michael Reese Hospital arna Northwe.~tern University Medioa'l Sehool) ACCORDING to leading authoritative works on gynecology, the !-\ bilateral polycystic ovary is most commonly found in association with utet'ine bleeding (Fig 1) This association has been recognized by the medical profession and is not infrequent in occurrence Endometrial hyperplasia, multiple follicle cysts with granulosa cell lining, and a notable absence of corpora lntea in the ovar;r are the significant pathologic findings in such cases The bleeding in these patients is readily explained by the fact that the increase in number of follicles lined by granulosa cells produces an excess of secretion of estrogenic hormone According to the same authoritative works, little or no mention is made of bilateral polycystic ovaries aceompanied by amenorrhea, and inasmuch as we have encountered a series of cases exemplifying the latter conditions, we desire to present the results of our study of them Cyst formation in the follicular apparatus of the ovary is very common and is regarded to some extent as a physiologic process When these structures are visible to the naked eye, they are regarded as cysts; when not, they are called follicles When this process becomes excessive, persistent or progressive, the ovary becomes enlarged, tense, tender and painful, and produces what has been termed "cystic degen•Read at a meeting of the Central Association of Obstar surface Large theca cyst with corpus albicans; recent corpus luteum CASE 7.-M B., aged twenty, single, was admitted to the hospital Aug 29, 1933 Her chief complaints were amenorrhea and pain in both lower quadrants for one STEIN-LEVENTHAT,: BJI,ATEHAL POLYf'Y,:TII ' OVA RIBS JR7 year Menses began at fourteen years of age, always irregular, six weeks to !'our months, usually two m«:'nths, seven-day duration, moderate, occasional clots, no dysm enorrhea Physical examination revealed a tall, thin girl, with muddy nHH plexion; facial acne; scant breast deYelopm ~ I old, ,small I jl'·ew, small ~ew: Many, old CORPORA ALBIC ANTI.\ HISTOPATHOLOGIC J of bilateral polyc,vsti