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~C00KIEEE~
ENCYCLOPEDIA OF
HUMAN
NUTRITION
SECOND EDITION
ENCYCLOPEDIA OF
HUMAN
NUTRITION
SECOND EDITION
Editor-in-Chief
BENJAMIN CABALLERO
Editors
LINDSAY ALLEN
ANDREW PRENTICE
ACADEMIC
PRESS
Amsterdam Boston Heidelberg London New York Oxford
Paris San Diego San Francisco Singapore Sydney Tokyo
Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK
ª 2005 Elsevier Ltd.
The following articles are US Government works in the
public domain and not subject to copyright:
CAROTENOIDS/Chemistry, Sources and Physiology
FOOD FORTIFICATION/Developed Countries
FRUCTOSE
LEGUMES
TEA
TUBERCULOSIS/Nutrition and Susceptibility
TUBERCULOSIS/Nutritional Management
VEGETARIAN DIETS
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any
means, electronic, or mechanical, including photocopy, recording, or any information storage and
retrieval system, without permission in writing from the publishers.
Permissions may be sought directly from Elsevier’s Rights Department in Oxford, UK:
phone (+44) 1865 843830, fax (+44) 1865 853333, e-mail permissions@elsevier.com.
Requests may also be completed on-line via the homepage (http://www.elsevier.com/locate/permissions).
Second edition 2005
Library of Congress Control Number: 2004113614
A catalogue record for this book is available from the British Library
ISBN 0-12-150110-8 (set)
This book is printed on acid-free paper
Printed and bound in Spain
EDITORIAL ADVISORY BOARD
EDITOR-IN-CHIEF
Benjamin Caballero
Johns Hopkins University
Maryland
USA
EDITORS
Lindsay Allen
University of California
Davis, CA, USA
Andrew Prentice
London School of Hygiene & Tropical Medicine
London, UK
Christopher Bates
MRC Human Nutrition Research
Cambridge, UK
Carolyn D Berdanier
University of Georgia
Athens, GA, USA
Bruce R Bistrian
Harvard Medical School
Boston, MA, USA
Johanna T Dwyer
Frances Stern Nutrition Center
Boston, MA, USA
Paul Finglas
Institute of Food Research
Norwich, UK
Terrence Forrester
Tropical Medicine Research Institute
University of the West Indies,
Mona Campus, Kingston, Jamaica
Hedley C Freake
University of Connecticut
Storrs, CT, USA
Catherine Geissler
King’s College London
London, UK
Susan A Jebb
MRC Human Nutrition Research
Cambridge, UK
Rachel Johnson
University of Vermont
Burlington, VT, USA
Janet C King
Children’s Hospital Oakland Research Institute
Oakland, CA, USA
Anura Kurpad
St John’s National Academy of Health Sciences
Bangalore, India
Kim Fleisher Michaelson
The Royal Veterinary and Agricultural University
Frederiksberg, Denmark
Carlos Monteiro
University of Sa
ˆ
o Paulo
Sa
ˆ
o Paulo, Brazil
John M Pettifor
University of the Witwatersrand & Chris
Hani-Baragwanath Hospital
Johannesburg, South Africa
Barry M Popkin
University of North Carolina
Chapel Hill, NC, USA
Michele J Sadler
MJSR Associates
Ashford, UK
Ricardo Uauy
London School of Hygiene and Tropical Medicine
UK and INTA University of Chile, Santiago, Chile
David York
Pennington Biomedical Research Center
Baton Rouge, LA, USA
vi EDITORIAL ADVISORY BOARD
FOREWORD
W
hy an encyclopedia? The original Greek word means ‘the circle of arts and sciences essential for a
liberal education’, and such a book was intended to embrace all knowledge. That was the aim of the
famous Encyclopedie produced by Diderot and d’Alembert in the middle of the 18th century, which
contributed so much to what has been called the Enlightenment. It is recorded that after all the authors
had corrected the proofs of their contributions, the printer secretly cut out whatever he thought might give
offence to the king, mutilated most of the best articles and burnt the manuscripts! Later, and less controver-
sially, the word ‘encyclopedia’ came to be used for an exhaustive repertory of information on some particular
department of knowledge. It is in this class that the present work falls.
In recent years the scope of Human Nutrition as a scientific discipline has expanded enormously. I used to
think of it as an applied subject, relying on the basic sciences of physiology and biochemistry in much the
same way that engineering relies on physics. That traditional relationship remains and is fundamental, but the
field is now much wider. At one end of the spectrum epidemiological studies and the techniques on which
they depend have played a major part in establishing the relationships between diet, nutritional status and
health, and there is greater recognition of the importance of social factors. At the other end of the spectrum
we are becoming increasingly aware of the genetic determinants of ways in which the body handles food and
is able to resist adverse influences of the environment. Nutritionists are thus beginning to explore the
mechanisms by which nutrients influence the expression of genes in the knowledge that nutrients are
among the most powerful of all influences on gene expression. This has brought nutrition to the centre of
the new ‘post-genome’ challenge of understanding the effects on human health of gene-environment interactions.
In parallel with this widening of the subject there has been an increase in opportunities for training and
research in nutrition, with new departments and new courses being developed in universities, medical schools
and schools of public health, along with a greater involvement of schoolchildren and their teachers. Public
interest in nutrition is intense and needs to be guided by sound science. Governments are realizing more and
more the role that nutrition plays in the prevention of disease and the maintenance of good health, and the
need to develop a nutrition policy that is integrated with policies for food production.
The first edition of the Encyclopaedia of Human Nutrition established it as one of the major reference
works in our discipline. The second edition has been completely revised to take account of new knowledge in
our rapidly advancing field. This new edition is as comprehensive as the present state of knowledge allows,
but is not overly technical and is well supplied with suggestions for further reading. All the articles have been
carefully reviewed and although some of the subjects are controversial and sensitive, the publishers have not
exerted the kind of political censorship that so infuriated Diderot.
J.C. Waterlow
Emeritus Professor of Human Nutrition
London School of Hygiene and Tropical Medicine
February 2005
INTRODUCTION
T
he science of human nutrition and its applications to health promotion continue to gain momentum. In
the relatively short time since the release of the first edition of this Encyclopedia, a few landmark
discoveries have had a dramatic multiplying effect over nutrition science: the mapping of the human genome,
the links between molecular bioenergetics and lifespan, the influence of nutrients on viral mutation, to name
a few.
But perhaps the strongest evidence of the importance of nutrition for human health comes from the fact
that almost 60% of the diseases that kill humans are related to diet and lifestyle (including smoking and
physical activity). These are all modifiable risk factors. As individuals and organizations intensify their efforts
to reduce disease risks, the need for multidisciplinary work becomes more apparent. Today, an effective
research or program team is likely to include several professionals from fields other than nutrition. For both
nutrition and non-nutrition scientists, keeping up to date on the concepts and interrelationships between
nutrient needs, dietary intake and health outcomes is essential. The new edition of the Encyclopedia of
Human Nutrition hopes to address these needs. While rigorously scientific and up to date, EHN provides
concise and easily understandable summaries on a wide variety of topics. The nutrition scientist will find that
the Encyclopedia is an effective tool to ‘‘fill the void’’ of information in areas beyond his/her field of
expertise. Professionals from other fields will appreciate the ease of alphabetical listing of topics, and the
presentation of information in a rigorous but concise way, with generous aid from graphs and diagrams.
For a work that involved more than 340 authors requires, coordination and attention to detail is critical.
The editors were fortunate to have the support of an excellent team from Elsevier’s Major Reference Works
division. Sara Gorman and Paula O’Connell initiated the project, and Tracey Mills and Samuel Coleman saw
it to its successful completion.
We trust that this Encyclopedia will be a useful addition to the knowledge base of professionals involved in
research, patient care, and health promotion around the globe.
Benjamin Caballero, Lindsay Allen and Andrew Prentice
Editors
April 2005
[...]... D H Williamson Radcliffe Infirmary Oxford, UK S Zidenberg-Cherr University of California at Davis Davis, CA, USA M-M G Wilson St Louis University St Louis, MO, USA T R Ziegler Emory University Atlanta, GA, USA xxv CONTENTS VOLUME 1 A ACIDS see ELECTROLYTES: Acid-Base Balance ´ ¨ G Fruhbeck and J Gomez-Ambrosi ADIPOSE TISSUE 1 ADOLESCENTS Nutritional Requirements Nutritional Problems AGING C H S Ruxton... Factors; Lipid Theory; Prevention HEIGHT see NUTRITIONAL ASSESSMENT: Anthropometry HOMOCYSTEINE HUNGER J W Miller 462 J C G Halford, A J Hill and J E Blundell HYPERACTIVITY 469 M Wolraich 475 HYPERLIPIDEMIA Overview T R Trinick and E B Duly Nutritional Management 479 A H Lichtenstein 491 HYPERTENSION Etiology T Morgan and H Brunner Dietary Factors L J Appel Nutritional Management HYPOGLYCEMIA 499 506... 1 7 INBORN ERRORS OF METABOLISM Classification and Biochemical Aspects D L Marsden Nutritional Management of Phenylketonuria D L Marsden, F J Rohr and K C Costas 13 22 INFANTS Nutritional Requirements Feeding Problems S A Atkinson 28 R M Katz, L Schuberth and C S Gulotta 42 INFECTION Nutritional Interactions H Ghattas Nutritional Management in Adults 47 J A Tayek 54 INTESTINE see SMALL INTESTINE: Structure... London, UK R Nalubola Center for Food Safety and Applied Nutrition, US Food and Drug Administration, MD, USA J W Miller UC Davis Medical Center Sacramento, CA, USA J L Napoli University of California Berkeley, CA, USA P Miller Kennedy–Krieger Institute Baltimore, MD, USA V Nehra The Mayo Clinic College of Medicine Rochester, MN, USA D J Millward University of Surrey Guildford, UK B Nejadnik Johns Hopkins... USA A P Simopoulos The Center for Genetics, Nutrition and Health Washington, DC, USA A O Scheimann Johns Hopkins School of Medicine Baltimore, MD, USA R J Smith Brown Medical School Providence, RI, USA B Schneeman University of California at Davis Davis, CA, USA P B Soeters University Hospital Maastricht Maastricht, The Netherlands xxiii xxiv CONTRIBUTORS N Solomons Center for Studies of Sensory Impairment,... Measurement the following information would be provided: DIETARY INTAKE MEASUREMENT Contents Methodology Validation xii GUIDE TO USE OF THE ENCYCLOPEDIA 2 Cross-References All of the articles in the Encyclopedia have been extensively cross-referenced The cross-references, which appear at the end of an article, serve three different functions For example, at the end of the ADOLESCENTS /Nutritional Problems... ACID RIBOFLAVIN THIAMIN: Physiology; Beriberi VITAMIN B6 BACTERIA see INFECTION: Nutritional Interactions; Nutritional Management in Adults BASES see ELECTROLYTES: Acid-Base Balance BEER see ALCOHOL: Absorption, Metabolism and Physiological Effects; Disease Risk and Beneficial Effects; Effects of Consumption on Diet and Nutritional Status BEHAVIOR E L Gibson and M W Green 183 BERIBERI see THIAMIN: Beriberi... and B J Petersen 366 G GALACTOSE A Abi-Hanna and J M Saavedra GALL BLADDER DISORDERS 377 B Nejadnik and L Cheskin 384 GERIATRIC NUTRITION see OLDER PEOPLE: Physiological Changes; Nutritional Requirements; Nutrition-Related Problems; Nutritional Management of Geriatric Patients GLUCOSE Chemistry and Dietary Sources D J A Jenkins, R de Souza, L S A Augustin and C W C Kendall Metabolism and Maintenance... Bloomberg School of Public Health Baltimore, MD, USA L S A Augustin University of Toronto Toronto, ON, Canada L H Allen University of California at Davis Davis, CA, USA D J Baer US Department of Agriculture Beltsville, MD, USA D Anderson University of Bradford Bradford, UK A Baqui Johns Hopkins Bloomberg School of Public Health Baltimore, MD, USA J J B Anderson University of North Carolina Chapel Hill,... CT, USA ´ J Gomez-Ambrosi Universidad de Navarra Pamplona, Spain J Freitas Tufts University Boston, MA, USA J M Graham University of California at Davis Davis, CA, USA R E Frisch Harvard Center for Population and Development Studies Cambridge, MA, USA J Gray Guildford, UK G Frost Imperial College at Hammersmith Hospital London, UK ¨ G Fruhbeck Universidad de Navarra Pamplona, Spain D Gallagher Columbia . London New York Oxford
Paris San Diego San Francisco Singapore Sydney Tokyo
Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK
ª. Health
Baltimore, MD, USA
L H Allen
University of California at Davis
Davis, CA, USA
D Anderson
University of Bradford
Bradford, UK
J J B Anderson
University of North