Recognized plant based anti cancer compounds type of compound plant origin Type of cancer 1 Vinblastine ( Velban) Monoterpene indole alkaloids Catharanthus roseus hodgkin Lymphoma 2 Vineristine ( Oncovin ) Alkaloids Catharanthus roseus blood cancer, Lymphomas 3 Taxol ( Paclitaxel) Diterpene Alkaloids T brevifolia cervical cancer, breast cancer, lung cancer, sacoma Kaposi 4 Vinorelbine ( Navelbine) Monoterpene indole alkaloids Catharanthus roseus Lymphoma, lung cancer 5 Etoposide The glycoside fo.
1 Recognized plant-based anti-cancer compounds Vinblastine ( Velban) Vineristine ( Oncovin ) Taxol ( Paclitaxel) Diterpene Alkaloids Vinorelbine ( Navelbine) Etoposide Monoterpene indole alkaloids The glycoside form of Podophyllotoxin Taxotere ( Docetaxel) 10- decacetyl baccatin III derivatives Camptothecin Quinoline alkaloids Cabazitaxel ( Jevtana) Taxoid 10deacetylbaccatin III derivatives Homoharringtonine; Omacetaxine mepesuccinate ( Ceflatonin) Ingenol mebutate ( Picato) Alkaloids 10 type of compound plant origin Type of cancer Monoterpene indole alkaloids Alkaloids Catharanthus roseus Catharanthus roseus T- brevifolia hodgkin Lymphoma blood cancer, Lymphomas cervical cancer, breast cancer, lung cancer, sacoma Kaposi Lymphoma, lung cancer Small- cell lung cancer, testicular cancer Esters of diterpene ingernol, acids of angelic Catharanthus roseus semisynthetic derivative of Podophyllotoxin ( Taxus brevifolia) Taxus, T.brevifolia, T.baccata, T.Canadenis, T cuspidata Camptotheca accuminata Taxus, T.brevifolia, T.baccata, T.Canadenis, T cuspidata Cephalotaxus harringtonia Euphorbia peplus Lungcancer, brain tumors, prostate cancer Stomach cancer, Rectal cancer, Colon cancer, bladder cancer Pancreatic cancer metastatic stage Acute Leukemia ( AML, APL) Skin cancer Cancer cells that are difficult to treat and grow rapidly can be destroyed by alkaloids from plants These are alkaloids extracted and isolated from natural plants such as periwinkle, There are four classes of plant-derived anticancer agents in the market today, the vinca alkaloids (vinblastine, vincristine and vindesine), the epipodophyllotoxins (etoposide and teniposide), the taxanes (paclitaxel and docetaxel) and the camptothecin derivatives (camptotecin and irinotecan) - Inhibition of cell division: cochicine 1 Vinca alkaloids - Vinca alkaloids (VA) are a versatile group of phytochemicals isolated from Catharanthus roseus (C roseus) (Apocynaceae) - Vinca alkaloids inhibit cell division by preventing the formation of fibroblasts: vinblastin, vincristin, vinorellbine (Navelbine) - employed in the theraphy of several type of cancer namely, breast, liver, leukemia, testes lung cancer - The vinca alkaloids (vincristine and vinblastine) bind a specific site termed as tubulin heterodimers (vinca-binding site) disrupting the functions of microtubules or by arresting cell cycle at metaphase - These derivatives are used alone or in combination with other phytochemicals agents to fight against large number of cancers the epipodophyllotoxins (etoposide and teniposide) Podophyllotoxic - the main component of Podophyllum peltatum , is widely known for its anti-cancer properties - The podophyllotoxin inhibits the enzyme topoisomerase II, which is essential for the biosynthesis of DNA such as etoposide Podophyllotoxin is a precursor to the Podophyllins group of cancer therapeutic compounds, which includes Etoposide, a drug used to treat testicular cancer, small cell lung cancer, non-lymphoid leukemia and non-Hodgkin lymphoma Currently, Etoposide is still one of the most popular drugs in the treatment of metastatic cancer on the market and is listed by WHO as the safest and most effective drugs for health the taxanes (paclitaxel and docetaxel) - Paclitaxel (taxol) was first extracted from the bark and leaf of Taxus baccata (T baccata) and T canadensis, Corylus avellana - Taxoids act by promoting the formation and immobilization of fibroblasts, resulting in inhibition of cell growth and multiplication: paclitaxel - The primary mechanism of taxanes is to induce microtubule stabilization, apoptotic cell death and mitotic arrest - Analogs of paclitaxel which are currently undergoing clinical trials include larotaxel, milataxel, ortataxel and tesetaxel - Furthermore, out of 069 cancer clinical trials documented by the National Cancer Institute as of July 2004, 248 are taxane-derived drugs, containing 134 with paclitaxel, 105 with docetaxel and 10 with miscellaneous taxanes are used either alone or together with other anticancer agents the camptothecin derivatives (camptotecin and irinotecan) - Campothecin (family of topoisomerase I poisons) is another class of plant derived clinically-active chemotherapeutic agents possesses strong anticancer potential inhibiting topoisomerase I in a large number of cancers - It was first isolated from Camptotheca acuminata (Nyssaceae) - effective camptothecin derivatives like topotecan (hycamtin) and irinotecan, where irinotecan is used to treat colorectal cancer while topotecan is used to treat ovarian and lung cancer ... testicular cancer, small cell lung cancer, non-lymphoid leukemia and non-Hodgkin lymphoma Currently, Etoposide is still one of the most popular drugs in the treatment of metastatic cancer on the... clinically-active chemotherapeutic agents possesses strong anticancer potential inhibiting topoisomerase I in a large number of cancers - It was first isolated from Camptotheca acuminata (Nyssaceae) - effective... ortataxel and tesetaxel - Furthermore, out of 069 cancer clinical trials documented by the National Cancer Institute as of July 2004, 248 are taxane-derived drugs, containing 134 with paclitaxel, 105