OPENING SESSION Monday AM OPENING SESSION Clyde Auditorium 07 45 08 20 Welcome and Medal Presentations Robert R Edelman, President, ISMRM Carlo Bartolozzi, President, ESMRMB FIFTH ANNUAL LAUTERBUR L[.]
Monday AM OPENING SESSION Clyde Auditorium 07:45 08:20 Welcome and Medal Presentations Robert R Edelman, President, ISMRM Carlo Bartolozzi, President, ESMRMB FIFTH ANNUAL LAUTERBUR LECTURE Clyde Auditorium 08:20 09:00 From the Genome to Molecular Imaging: Dream or Reality? George K Radda Medical Research Council London, England, UK PLENARY LECTURES New Contrast Agents Clyde Auditorium 09:00 10:15 Chairs: Jeffrey L. Evelhoch P.V. Prasad Educational Objectives Upon completion of this session, participants should be able to 9:00 List examples of specific molecular targets which fluorescent probes can be used to identify and/or quantify Identify approaches that are being used to develop MR contrast agents which can be used to identify and/or quantify specific molecular targets Explain how a MR contrast agent can be activated by an enzyme Compare and contrast the advantages and disadvantages of fluorescent probes and MR contrast agents for identifying specific molecular targets Predict what role targeted MR contrast agents will play in future clinical practice Imaging Fluorescent Probes in Living Cells, Tissues and Animals Stephen R. Adams University of California, San Diego, La Jolla, CA, USA 9:25 AffinityTargeted Contrast Agents Samuel A. Wickline, Gregory M. Lanza Washington University School of Medicine, Saint Louis, MO, USA 9:50 Seeing is Believing: Visualizing In Vivo Gene Expression and Secondary Messengers by MRI Thomas J Meade California Institute of Technology, Pasadena, CA, USA Monday AM Image Reconstruction Methods Clyde Auditorium 11:00 13:00 Chairs: James G. Pipe E. Mark Haacke 11:00 Young Investigator Awards Finalist: Advances in Sensitivity Encoding with Arbitrary kSpace Trajectories Klaas Paul Pruessmann1, Markus Weiger1, Peter Börnert2, Peter Boesiger1 1ETH and University Zurich, Zurich, Switzerland; 2Philips Research, Hamburg, Germany 11:20 Young Investigator Awards Finalist: Unifying Linear Priorinformationdriven Methods for Accelerated Image Acquisition — Development of a Broaduse Linear Acquisition Speedup Technique (BLAST) to Overcome Existing Limitations Jeffrey Tsao1, Babak Behnia1, Andrew Webb1 1University of Illinois at UrbanaChampaign, Urbana, IL USA. 11:40 SumofSquares Image Reconstruction with SMASH Michael A. Ohliger1, Charles A. McKenzie1, Ernest N. Yeh1, Mark D. Price1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, HarvardMIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA USA 11:52 New Approaches to SelfCalibrating Parallel Imaging Charles A. McKenzie1, Mark D. Price1, Ernest N. Yeh1, Michael A. Ohliger1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, HarvardMIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA USA. 12:04 Pushbutton PPA Reconstructions: GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) Mark Griswold1, Peter Jakob1, Robin Heidemann1, Mathias Nittka1, Jianmin Wang2, Berthold Kieffer2 1Universität Würzburg, Würzburg, Germany; 2Siemens Medical Engineering, Erlangen, Germany 12:16 FUSION for Incremental FieldofView Imaging Yudong Zhu1 1GE Corporate R&D Center, Niskayuna, NY, USA. 12:28 10 Dynamic Imaging by Temporal Modeling with Principal Component Analysis Ananya Sen Gupta1, ZhiPei Liang1 1University of Illinois at UrbanaChampaign, Urbana, IL USA. 12:40 11 Establishing T2Contrast in True FISP Imaging Robin Heidemann1, Mark Griswold1, Claudia Hillenbrand1, Dietbert Hahn2, Axel Haase1, Peter Jakob1 1Universität Würzburg, Würzburg, Germany; 2Institut für Röntgendiagnostik, Würzburg, Germany. Monday AM RF Coil Design and Applications Lomond 11:00 13:00 Chairs: Christopher M. Collins Helmut Merkle 11:00 12 A Four Channel Transceive Phased Array Head Coil for 3T Scott B. King1, Randy Duensing2, Stephen Varosi3, David Peterson4, David A. Molyneaux4 1MRI Devices Corporation, Gainesville, FL USA.; 2Applied Resonance Technology, Inc., Gainesville, FL, USA ; 3University of Florida, Applied Resonance Technology, Inc., Gainesville, FL, USA ; 4MRI Devices Corporation, Gainesville, FL, USA 11:12 13 A Large Volume FourRing Birdcage Transmit/Receive Coil for 3.0 T Head Imaging Labros Petropoulos1, Joseph MurphyBoesch1 1USA Instruments, Aurora, OH, USA. 11:24 14 OpenFace Quadrature "Birdcage" Head Coil Hiroyuki Fujita1, William O. Braum2, Gordon Demeester3 1USA Instruments, Inc., Aurora, OH, USA; 2Marconi Medical Systems, Cleveland, OH, USA; 3Wickliffe, OH, USA 11:36 15 The Head Cradle: An Open Faced, High Performance TEM Coil J. Thomas Vaughan1, Gregor Adriany1, Michael Garwood1, Peter Andersen1, Kamil Ugurbil1 1The University of Minnesota, Center for Magnetic Resonance Research, Minneapolis, MN, USA; 11:48 16 Design of Planar Strip Array for MRI Ray Lee1 1General Electric Co., Corporate Research & Development Center, Niskayuna, NY, USA 12:00 17 Ladder Networks for Capacitive Decoupling in PhasedArray Coils * Jovan Jevtic1 1IGCMedical Advances Inc., Milwaukee, WI, USA. 12:12 18 Arrays of Birdcage Coils for Imaging Multiple Samples Steven M. Wright1, Mary McDougall1, David G. Brown1, John Hazle2 1Texas A&M University, College Station, TX, USA; 2University of Texas M.D. Anderson Cancer Center, Houston, TX, USA 12:24 19 Two Methods for MultiSample Imaging: Applications to Mouse Phenotyping via MRI H. Douglas Morris1, Scott Chesnick1 1National Institutes of Health, Bethesda, MD, USA. 12:36 20 Varactor Tuned Flexible Interventional Receiver Coils Greig Scott1, Garry E. Gold1 1Stanford University, Stanford, CA, USA. 12:48 21 Concentric Coil Arrays for Spatial Encoding in Parallel MRI Michael A. Ohliger1, Robert Greenman1, Charles A. McKenzie1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Boston, MA, USA. Monday AM CLINICAL CATEGORICAL COURSE Cardiac MR Imaging Hall 2 11:00 13:00 Chairs: Zahi A. Fayad Christopher M. Kramer Educational Objectives: Upon completion of this course, participants should be able to Describe basic areas of routine and promising use of clinical MR in assessing cardiovascular disease Describe methodology and interpret results for MR assessment of acquired and congenital heart disease Apply MR protocols for the evaluation of cardiac morphology, function, viability, and blood flow Compare approaches for optimal presentation and analysis of cardiac MR results 11:00 Introduction Dudley J Pennell 11.25 Congenital Heart Disease Albert de Roos 11:50 MR Coronary Angiography John N Oshinski 12:15 Atherosclerotic Plaque Characterization Zahi A Fayad 12:40 Discussion Monday AM fMRI Data Analysis Hall 5 11:00 13:00 Chairs: Mark J. Lowe James J. Pekar 11:00 22 Physiological Noise Reduction in fMRI Using Vessel TimeSeries as Covariates in a General Linear Model Torben Lund1, Lars Hanson1 1Hvidovre Hospital, Hvidovre, Denmark. 11:12 23 Detection Of Time Windows Of Brain Responses in fMRI Using Modified Temporal Clustering Analysis SeongHwan Yee1, Trevor Andrews1, JiaHong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TS, USA. 11:24 24 Spatial & Temporal Independent Component Analysis of fMRI Data with Two TaskRelated Waveforms James J. Pekar1, Vince Calhoun2, Tulay Adali3, Godfrey D. Pearlson2 1Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Baltimore, MD, USA; 3University of Maryland Baltimore County, Baltimore, MD, USA. 11:36 25 The Use of SpatioTemporal Properties to Detect Activation in EventRelated fMRI Data ShingChung Ngan1, William Auffermann1, Shantanu Sarkar1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 11:48 26 Simulation Studies on the Performance of Independent Component Analysis in Analyzing fMRI Data with Transient, Randomly Occurring Events Hong Gu1, Hanhua Feng1, Wang Zhan2, Su Xu1, David A. Silbersweig1, Emily Stern1, Yihong Yang2 1Weill Medical College of Cornell University, New York, NY, USA; 2Memorial SloanKettering Cancer Center, New York, NY, USA 12:00 27 Using the Cortical Surface Information for the Detection of fMRI Activation Signal JeanBaptiste Poline1, Alexandre Andrade1, Ferath Kherif1, Stephane Bahrami1, Isabelle Klein1, JeanFrancois Mangin1, Keith J. Worsley2, Denis Le Bihan1 1SHFJ Commissariat a l'Energie Atomique, Orsay, France; 2McGill University, Montreal, Canada. 12:12 28 Suppresion of NonCapillary BOLD Signals Through The Use Of Phase Fluctuations Ravi S. Menon1 1The John P. Robarts Research Institute, London, ON, Canada. 12:24 29 Ballistocardiogram Removal and Motion Correction for EEG in the Magnet Patrick L. Purdon1, Iiro P. Jaaskelainen1, Victor Solo2, Emery N. Brown3, John W. Belliveau1, Giorgio Bonmassar1 1Massachusetts General Hospital, NMR Center, Charlestown, MA, USA; 2University of New South Wales, Sydney, NSW, Australia; 3Massachusetts General Hospital, Boston, MA, USA. 12:36 30 Resting State Neurovascular Fluctuation At Different States Of Conciousness Vesa Johannes Kiviniemi1, JuhaPekka Kantola1, Bharat Biswal2, Osmo Tervonen1, Jukka Jauhiainen1 1Oulu University Hospital, Oulu, Finland; 2Medical College of Wisconsin, Milwaukee, WI, USA 12:48 31 Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in "RestingState" Data Dietmar Cordes1, V.M Haughton1, Konstantinos Arfanakis1, J.D Carew1, P.A Turski1, C.H Moritz1, M.A Quigley1, M.E Meyerand1 1University of WisconsinMadison, Madison, WI, USA Monday AM MR Imaging of Articular Cartilage Hall 1 11:00 13:00 Chairs: Garry E. Gold Douglas W. Goodwin 11:00 32 Comparison of dGEMRIC and T2 Imaging of Articular Cartilage Nina M. Menezes1, Martha L. Gray2, Deborah Burstein3 1Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Massachusetts Institute of Technology, Cambridge, MA, USA; 3Beth Israel Deaconess Medical Center, Boston, MA,USA. 11:12 33 GdDTPA2enhanced T1 Imaging of Proteoglycans Predicts Cartilage Stiffness in Bovine Humeral Head Miika T Nieminen1, Juha Töyräs2, Mikko S Laasanen2, Jarno Rieppo1, Johanna Silvennoinen3, Heikki J Helminen1, Jukka S Jurvelin2 1University of Kuopio, Kuopio, Finland; 2Kuopio University Hospital, Kuopio, Finland; 3A.I.Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. 11:24 34 Relaxivity of Gadolinium Agents in Cartilage at 2T: Effects on dGEMRIC Imaging Amy M. Gillis1, Martha Gray1, Deborah Burstein1 1Beth Israel Deaconess Medical Center, Boston, MA, USA. 11:36 35 Magnetic Resonance Imaging of Porcine Articular Cartilage before and after Cryopreservation L. Laouar1, K. Fishbein2, N. Jomha1, L. E. McGann1, R.G.S. Spencer2 1University of Alberta, Edmonton, Alberta, Canada; 2National Institutes of Health, Baltimore, MD, USA. 11:48 36 Cartilage Anisotropic Deformation Yields a Dual Role for Proteoglycan Content Jonathan Kaufman1, Umamaheswar Duvvuri1, Ravinder Regatte1, Ravinder Reddy1, John S. Leigh1 1University of Pennsylvania, Philadelphia, PA, USA. 12:00 37 In Vivo Assessment Of Proteoglycan Loss In The Articular Cartilage Of The Goat Knee With GadoliniumEnhanced MRI After Papain Injection Didier Laurent1, James Wasvary1, Jianyun Yin1, Hem Nalini Singh1, Gary Pastor1, Vincent Blancuzzi1, Elizabeth O'Byrne1, Theodore Pellas1 1Novartis Pharmaceuticals Corporation, Summit, NJ, USA 12:12 38 Multinuclear MRI Evauation of Cartilage Degeneration Erik M. Shapiro1, Arijitt Borthakur1, Jonathan Kaufman1, John S. Leigh1, Ravinder Reddy1 1University of Pennsylvania, Philadelphia, PA, USA. 12:24 39 Measurement of Cartilage's Internal Elastic Properties Using MR Elastography Anne C. Ridler, Don B. Plewes, and R. Mark Henkelman1 1University of Toronto, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada; 12:36 40 Vertical Striations in the Radial Layer of MR Images of Hyaline Cartilage are due to T2 Effects Goodwin D.W.1, Hao Lei1, J. F. Dunn1 1Dartmouth Medical School, Hanover, NH, USA. 12:48 41 Assessment Of Collagen Integrity In Articular Cartilage By Using Magnetization Transfer Imaging: In Vivo Application To The Goat Knee Didier Laurent1, James Wasvary1, Jianyun Yin1, Hem Nalini Singh1, Gary Pastor1, Vincent Blancuzzi1, Theodore Pellas1, Elizabeth O'Byrne1 1Novartis Pharmaceuticals Corporation, Summit, NJ, USA Monday AM Peripheral MR Angiography Techniques Forth 11:00 13:00 Chairs: Stefan G. Ruehm James F.M. Meaney 11:00 42 Multicenter Trial of SteadyState MR Angiography of the Peripheral Arteries with NC100150 (CLARISCAN) for the Evaluation of Peripheral Arterial Disease Tim Leiner1, Kai Yiu J.A.M. Ho1, Vincent B. Ho2, Georg Bongartz3, Willem P. Th. M. Mali4, Jos M.A. van Engelshoven1 1Maastricht University Hospital, Maastricht, The Netherlands; 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 3University Hospital Basel, Basel, Switzerland; 4Academic Hospital Utrecht, Utrecht, The Netherlands. 11:12 43 Contrast Enhanced MRA Of The Lower Extremity: ArterialVenous Transit Of Contrast Bolus And Venous Contamination Yi Wang1, Priscilla A Winchester1, Catherine Zheng Chen1, Richard Watts1, Neil M Khilnani1, Martin R. Prince1 1Cornell University, Weill Medical College, New York, NY, USA. 11:24 44 ContrastEnhanced, SingleInjection, MRA with Automated Table Movement Compared to MultiInjection, TimeResolved CE 3DMRA of the RunOff Vessels Thomas Hany1, Timothy Carroll1, Reed Omary1, Emilio EsparzaCoss1, Frank R. Korosec1, Charles A. Mistretta1, Thomas Grist1 1University of WisconsinMadison, Madison, WI, USA. 11:36 45 High Resolution Whole Body 3D MR Angiography (AngioSURF): Initial Clinical Experience Mathias Goyen1, Harald H Quick1, Jörg F Debatin1, Mark E Ladd1, Hilmar Kühl1, Silke Bosk1, Jörg Barkhausen1, Stefan G Ruehm1 1University Hospital Essen, Essen, Germany; 11:48 46 Automated Realtime Multistation Projection MR Angiography (`Bolus Prep´) Hani Marcos1, Peter Choyke1, Vincent B. Ho2, Maureen N. Hood2, Thomas Foo3 1National Institutes of Health, Bethesda, MD, USA; 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 3G. E. Medical Systems, Milwaukee, WI, USA. 12:00 47 Contrast Travel Times Measured On 2D Projection MRA In Patients With Peripheral Vascular Disease Martin R. Prince1, Yi Wang1, Richard Watts1, Catherine Chen1, Neil M Khilnani1, David W Trost1, Priscilla A. Winchester1 1Cornell University, Weill Medical College, New York, NY, USA. 12:12 48 3D GdEnhanced Moving Table MR Angiography of the Aorta and Outflow Vessels using SENSE to Achieve High Resolution of the Below Knee Vasculature Jeffrey H Maki1, Gregory J Wilson1, Romhild M Hoogeveen2 1Puget Sound VA HCS, Seattle, WA, USA; 2Philips Medical Systems, Best, The Netherlands. 12:24 49 Improving Spatial Resolution and SNR in TimeResolved Peripheral MRA Using Extended DualResolution PR Acquisition Jaing Du1, Timothy Carroll1, Karl Vigen1, Yousef Mazaheri2, Charles M. Strother1, B Aargard1, Thomas Hany1, Thomas Grist1, Charles A. Mistretta1 1University of WisconsinMadison, Madison, WI, USA; 2Medical College of Wisconsin, Milwaukee, WI, USA 12:36 50 High Resolution MRA For The Study Of Arteriogenesis In Rodent Models Of Peripheral Artery Disease SimonPeter Williams1, Joan Greve1, Richard Carano1, Lisa Bernstein1, Adrienne Ross1, Jed Ross1, Nicholas Van Bruggen1 1Genentech, Inc., South San Francisco, CA, USA. Monday AM 12:48 51 MR Angiography of Hemodialysis Access Grafts and Fistulae using Selective Contrast Injection and Flow Interruption Clemens Bos1, Johannes H.M. Smits2, Jan J. Zijlstra2, Wil A.M.A. Van Der Mark2, Peter J. Blankestijn2, Chris J.G. Bakker2, Max A. Viergever1, Willem P.Th.M. Mali2 1Image Sciences Institute, AZU, Utrecht, The Netherlands; 2University Medical Center Utrecht, Utrecht, The Netherlands Monday AM New MR Contrast Agents & Applications Alsh 11:00 13:00 Chairs: Jeff W.M. Bulte Gregory M. Lanza 11:00 52 Cellular Imaging using Magnetodendrimers: Application to Human Stem Cells and Neoplastic Cells In Vivo J.W.M Butle1, Trevor Douglas2, P. van Gelderen3, B.K Lewis1, J.A Frank1 1Laboratory of Diagnostic Radiology Research, Bethesda, MD, USA; 2Temple University, Philadelphia, PA, USA; 3National Institutes of Health, Bethesda, MD USA 11:12 53 MR Molecular Imaging of Her2/Neu Receptor with Targeted Nanoparticles Dmitri Artemov1, Noriko Mori1, Rajani Ravi1, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 11:24 54 Relaxivities of Paramagnetic Nanoparticle Contrast Agents for Targeted Molecular Imaging Patrick Winter1, Junjie Chen1, ShengKwei Song1, Ralph W. Furhop1, Samuel A. Wickline1, Gregory M. Lanza1 1Washington University School of Medicine, St. Louis, MO, USA. 11:36 55 Intracellular Trapping of a Contrast Agent: A Tool for MRIBased Atraumatic Mapping of Electrotransfer Anne LeroyWillig1, Elodie Parzy1, G. Vidal2, Pierre Carlier3, C. Wary2, M. PaturneauJouas2 1AFM, CEA and INSERM U494, Paris, France; 2Institut de Myologie, France; 3JemeppeSurSambre, Belgium. 11:48 56 An MRI Comparative Study on Contrast Enhancement of Necrosis by MP2269 and Gadophrin2 in a Rat Model of Liver Infarction Yicheng Ni1, Kofi Adzamli2, Yi Miao1, Erwin Cresens1, Jie Yu2, MP Periasamy2, Max D Adams2, Guy Marchal1 1University Hospitals K.U. Leuven, Leuven, Belgium; 2Mallinckrodt, Inc., St Louis, MO, USA 12:00 57 Albuminbinding MR Blood Pool Agent Contrast Enhancement in Mouse Glioma Kofi Adzamli1, Dmitriy Yablonskiy2, Michael Chicoine3, Eun Kyung Won3, Karen P. Galen3, Zahner Michael3, Joseph J.H. Ackerman4, Thomas A. Woolsey4 1Mallinckrodt, Inc., St. Louis, MO, USA; 2Olivette, MO, USA ; 3St. Louis, MO, USA; 4Washington University, School of Medicine, St. Louis, MO, USA. 12:12 58 Imaging of Lymphatic Anatomy and Function in Mouse Adults and Pups with GdDTPAalbumin Paul A. Schornack1, Teressa Myloyde1, Zaver Bhujwalla2, Marlys H. Witte1, Robert J. Gillies1 1University of Arizona, Tucson, AZ USA; 2Johns Hopkins University, Baltimore, MD, USA. 12:24 59 Thrombus Detection and Contrast Enhancement Kinetics Using a Novel Fibrin Targeted MR Nanoparticle Contrast Agent Xin Yu1, Shelton Caruthers2, Scott M. Love1, Michael J. Scott1, Ralph W. Fuhrhop1, Patrick J. Gaffney3, Samuel A. Wickline1, Gregory M. Lanza1 1Washington University, St. Louis, MO USA; 2Rockland, MA, USA; 3St. Thomas's Hospital, London, England, UK 12:36 60 pH Responsive Gadolinium Chelates as Novel MRI Contrast Agents Yoko Kawata1, Heribert SchmittWillich2, Thomas Frenzel2, Hans Bauer2, HannsJoachim Weinmann2 1Nihon Schering K.K., Osaka, Japan; 2Schering AG, Berlin, Germany. 12:48 61 A Eu3+based Magnetization Transfer Contrast Agent Shanrong Zhang1, Patrick Winter2, Kuangcong Wu1, A. Dean Sherry3 1University of Texas at Dallas, Richardson, TX, USA; 2University of Texas Southwestern Medical Center, Dallas, TX, USA; 3University of Texas at Dallas & University of Texas Southwestern Medical Center, Richardson & Dallas, TX, USA. Monday PM GOLD CORPORATE MEMBER LUNCHTIME SYMPOSIUM Nycomed Amersham Quantitative Perfusion Weighted MRI: Current Clinical Trends and Future Prespectives Argyll (Moat House) 13:00 – 14:00 Chair: Robert R. Edelman Brain – Towards Measuring Metabolism Leif Østergaard Aarhus, Denmark Body – New Perspectives for Kidneys and the Heart Stefan Schoenberg Heidelberg, Germany Panel Discussion Nycomed Amersham ISMRM Fellow’s Presentation: Uterine MRI Suny Abbara University of Hawaii, Honolulu, HI, USA 10