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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 56) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 56) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 56) doc

... tropane alkaloids ( belladonna alkaloids), such as atropineb ( dl-hyoscyamine) and hyoscine ( dl-scopo-lamine), in its seeds and every part of the plant. Its seeds and leaves have long been being ... as a folk medicine in Japan. Seishu Hanaoka, a Japanese surgeon,  rst used this plant for gen-eral anaesthesia in 1804.Many other species of solanaceous plants, such as Atropa, Scopolia and ... Tropane alkaloids HPLC analysis Reagents and their preparation•  e acetonitrile solutions of l-hyoscyamine and l-scopolamine are prepared as described in the GC/MS section.• A 2-g aliquot of...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 30) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 30) doc

... chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS). A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam and 50 ng of alprazolam were added ... described. In addition, the LC/MS analysis of triazolam, and its metabolites 4-hydroxy-triazolam and α-hydroxytriazolam is also presented.GC/MS analysis of benzodiazepines in blood and urineReagents ... 4-hydroxytriazolam and α-hydroxytriazolam in plasma and urine.  e quantitativeness could be observed in the range of 50–400 ng/mL for all compounds in both plasma and urine.Toxic and fatal concentrationsBenzodiazepines...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 33) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 33) doc

... dissolved in 100 µL methanol, and a 1- L aliquot of it is injected into GC. For quantitation, the peak area ratio of a target compound to IS is obtained.vi. For quantitative analysis, a 1 0- L of IS ... method using a DB-1 capillary column. Many compounds ap-peared as sharp peaks. With an intermediately polar DB-17 capillary column, sharp peaks also appeared. By using both DB-1 and DB-17 columns, ... limit was reported to be 1 ng/mL.HPLC analysis of diphenyhydramine in blood and urine320 Diphenylmethane antihistaminics HPLC analysis of chlorpheniramine and its metabolites in blood and urine...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 34) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 34) doc

... Shinozuka T, Terada M (1995) Standard methods of chemical analysis in poisoning VII, analgesics and anti-pyretics, the 115th Annual Meeting of the Pharmaceutical Society of Japan, the data of ... Table 2.1) are non-steroidal and anti- in ammatory drugs. As one of mechanisms of their pharmacological actions, inhibition of prostaglandin biosynthesis can be mentioned. Although fatal cases ... Rapid high-performance liquid chromatographic assay for the simul-taneous analysis of non-steroidal anti-inflammatory drugs in plasma. J Chromatogr 416:293–302 9) Shinozuka T, Nakajima R, Takei...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 35) docx

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 35) docx

... admission.Notes a)  e APAP metabolites (APAP-glucuronide, catechol 3-hydroxyaminophen, APAP-N-sul-fate, 3-cysteinyl APAP, 3-methoxy APAP and APAP-3-mercapturic acid) are not commer-cially available; ... metabolites in urine [4]Reagents and their preparation• APAP (Eastmann, Rochester, NY, USA) and APAP metabolites a (APAP-glucuronide, cat-echol 3-hydroxyaminophen, APAP-N-sulfate, 3-cysteinyl ... 17) Campanero MA, Calahorra B, Garcia-Quetglas E et al. (1999) Rapid liquid chromatographic assay for the deter-mination of acetaminophen in plasma after propacetamol administration: application...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 41) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 41) doc

... described in Chapter 4 can be also used for analysis of sali-cylic acid. Methyl salicylate, being used as a topical analgesic-antiphlogistic drug, is also me-tabolized into salicylic acid; therefore, ... tinnitus, bradyacusia, amblyopia and sweating [1].For analysis of salicylic acid, HPLC methods were reported [2–7]. In this chapter, a method for HPLC analysis of salicylic acid in serum specimens ... ver-rucae; the acid is included in adhesive plasters, ointments and liquid medicines as their ingre-dient for removing the stratum corneum. Since such products containing salicylic acid are easily...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 42) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 42) doc

... phenylbutazone, mefenamic acid and ca eine.  e total analysis time per sample was less than 25 min.HPLC-UV analysis of cephem antibiotics in plasma with a column-switching system400 β-Lactam antibioticsPoisoning ... Application of ion-exchange cartridge clean-up in food analysis. IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin in bovine ... resulting fatality due to anaphylactic shock, such a case is regarded as malpractice. HPLC chromatograms of human blank plasma (a) and blank plasma spiked with cefoxitin, cefuroxime, cephalexin...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 44) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 44) doc

... wrist of about 4 cm length; X-ray photographs, no  nding in the chest and intestinal gas observable in the abdomen. A er admission, gastrolavage and administration of activated charcoal and ... 9,10-dimethoxy-2-anthracene sulfonate (DMAS) as a  uorogenic reagent with excitation at 383 nm and emission at 459 nm.Poisoning case, and toxic and fatal concentrationsPoisoning case A 22-year-old male ... µg/mL; GC/MS analysis was made after liquid-liquid extraction.⊡ Figure 2.4411 HPLC analysis Benzalkoniums in plasma can be extracted by solid-phase extraction with a C18 column, and analyzed...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 1) doc

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 1) doc

... Poisons in Humans A Handbook of Practical Analysis Osamu Suzuki and Kanako Watanabe Drugs and Poisons in Humans A Handbook of Practical Analysis With 236 Figures and 90 Tables 123Prof. Osamu ... Suzuki and Dr. Watanabe have gathered an extensive array of methods for the measure-ment of xenobiotics and metabolites in biological matrices. Drugs and Poisons in Humans. A Handbook of Practical ... Drugs and Poisons in Humans. A Handbook of Practical Analysis. Dr. Osamu Suzuki and Dr. Mikio Yashiki, two outstanding Japanese scientists,  rst published the Handbook in Japanese in 2002....
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 3) docx

Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 3) docx

... superior vena cava and aorta [31].Postmortem diff usion of drugs from the trachea into heart blood22 Pitfalls and cautions in analysis of drugs and poisons In Japan, XylocaineTM jelly is usually ... during in vitro storage of specimens obtained from a nitrazepam user at autopsySpecimen Immediately after autopsy 10 days after autopsy*Nitrazepam 7-Aminonitrazepam Nitrazepam 7-AminonitrazepamCerebral ... membranes and organelles are damaged. In the cells, energy-requir-ing bindings of proteins with drugs are inhibited, and pH is lowered as a result of accumulation of lactic acid produced by anaerobic...
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