Tài liệu Pharmaceutical Coating Technology (Part 1) ppt

... • Sugar coating • Film coating • Particulate/pellet coating • Compression coating. Page i Pharmaceutical Coating Technology Page 3 one hundred of these pans to be installed in a coating department. ... The coating process Graham C.Cole Summary 170 7.1 Process development of aqueous film coating 170 7.2 Theoretical considerations of film coating 172 7.3 The mec...

Ngày tải lên: 24/12/2013, 18:15

... E.F.T. (1988) Int. J. Pharm. 48, 63–77. Handbook of Pharmaceutical Excipients (1986) American Pharmaceutical Association, Washington and Royal Pharmaceutical Society, London. Hansen, C.M. (1967) ... Aqueous polymeric coatings for pharmaceutical dosage forms (ed. McGinity, J.W.), Marcel Dekker, New York, 153–247. Lehmann, K. (1989b) In A practical course in lacquer coating, R...

Ngày tải lên: 24/12/2013, 18:15

... process of film coating of pharmaceutical solid dosage forms, one cannot escape a consideration of surface aspects relating to the wetting of granule, pellet or tablet cores by the coating solution ... to produce much more efficient and elegant films. Film coatings are invariably applied in the pharmaceutical industry by spraying a coating solution or suspension onto the surface...

Ngày tải lên: 24/12/2013, 18:15

... efficiency is reduced during the coating process. This will affect the coating, resulting in a reduction of the rate of evaporation, a reduction in the spray rate and longer coating times. It is, therefore, ... pneumatically from a silo to the coating pan. The illustrations in Fig. 8.11 shows a silo feeding tablets into the coating pan. Page 217 Fig. 8.10 Laboratory coating Pa...

Ngày tải lên: 22/01/2014, 00:20

... specifications • equipment required for the coating process, e.g. coating solution or suspension, preparation vessels, mills, mixers, homogenizers, coating pans, spray - guns • service requirements ... used in a coating pan and for the coating process. Compressed air is the utility service selected as it is a product contact material, i.e. it is used in the spraying operation...

Ngày tải lên: 22/01/2014, 00:20

... from organic solvent coating to aqueous coating? Answer: Looking first of all at the formulation-based parameters, there is a need to increase the solids loading of the coating suspension to ... used for making coating suspensions of aqueous systems. 4. Question: When do I need to add a plasticizer to a coating formula? Answer: Generally plasticizers are added to coating fo...

Ngày tải lên: 22/01/2014, 00:20

... steps involved in sugar coating are covered in som e detail, i.e. sealing, subcoating, smoothing, colour coating, polishing and printing. In the section dealing with subcoating several suitable ... the dosage form. 3.1 INTRODUCTION The pharmaceutical process of sugar coating remains a widely practised technology despite the interest arising from film -coating techniques since...

Ngày tải lên: 24/12/2013, 18:15

... practice in pharmaceutical coating, the ability of the coating equipment to evaporate the solvent satisfactorily may be overcome and the product overwetted, resulting in poor-quality coatings. ... granule or multiparticulate film coating to date, since those available either have difficulty in coping with the flow rates required for either organic or aqueous film coating, produce d...

Ngày tải lên: 24/12/2013, 18:15

... designed for aqueous film coating in a side-vented pan. A comparison is made of energy requirements of a column -coating system and a coating pan. All the major operational coating parameters can ... Q=GC p .ΔT=9010×0.25×4.2×40 Table 6.3 Energy balance: comparison of a 1500 mm diameter coating pan and a 450 mm fluidized bed coating column 1500 mm coating pan 450 mm column...

Ngày tải lên: 24/12/2013, 18:15

... 170 7 The coating process Graham C.Cole SUMMARY In recent years tablet coating has undergone several fundamental changes. The original sugar -coating technique has been largely replaced by film -coating ... parts of the equipment can provide a reduction in the overall coating cycle. 7.1 PROCESS DEVELOPMENT OF AQUEOUS FILM COATING Coating of tablets and pills is one of the oldest...

Ngày tải lên: 22/01/2014, 00:20