Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"

... reserved Research Paper Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression Ana Lustig1, Arnell Carter1, Dorothy Bertak1, Divya Enika1, Bolormaa Vandanmagsar1, ... significantly change with thymocyte age. Interesting, the expression of several immunoglobulin chains were also found to be significantly increased in aged...

Ngày tải lên: 03/11/2012, 11:35

... amounts of sialylated Hex3 glycoforms were indicated. b Minor amounts of Hex2 and Hex3 glycoforms lacking acetyl groups or containing a second glycyl group were indicated. c Very minor amounts of ... nd wild-type strains of H. in uenzae by us and others [10–19] have resulted in a structural model consisting of a conserved triheptosyl inner-core moiety (labelled HepI–HepIII) in...

Ngày tải lên: 31/03/2014, 21:21

... represents the general trend of protein changes for the experimental sample to control detected by using the Odyssey Infrared Imaging System. (+) means an increase of signal intensity, and (-) means ... represents the general trend of protein changes for the experimental sample to control detected by using the Odyssey Infrared Imaging System. (+) means an increase of signal intens...

Ngày tải lên: 31/10/2012, 15:12

... the pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 healthy individuals. ... healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7%...

Ngày tải lên: 31/10/2012, 16:49

... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain. Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64. Groups of four mice were injected intramuscularly ... first three domains and are present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64. Cytotoxicity was analyz...

Ngày tải lên: 21/02/2014, 01:21

... Mchaourab, H.S. (1999) Folding pattern of the a-crystallin domain in aA-crystallin determined by site-directed spin labelling. J. Mol. B iol. 294, 561–577. 68. To ¨ ro ¨ k, Z., Goloubinoff, P., Horva ´ th, ... [66], and disassembly of active units from an oligomeric (storage) state of a-crystallin was proposed, upon structural analysis of aA-crystallin by site- directed spin labell...

Ngày tải lên: 22/02/2014, 04:20

... indicating either a direct interaction with the triad amino acids or a consequence of steric hindrance causing an interference in enzymatic activity. In conclusion, by analyzing individual phage antibodies isolated ... proteins in rye, barley and possibly oats [1], with gliadins, specific antigenic determinants found in glutens [2], playing a prominent role. The disease is characteri...

Ngày tải lên: 08/03/2014, 09:20

... 2-N-(3-O- acyl 4 -acyl 2 )-b-GlcN-(1–6)-2-N-acyl 1 )3-O-acyl 3 -GlcN where acyl 1 ,acyl 2 and acyl 3 are 3-hydroxyhexadecanoic or 3-hy- droxyoctadecanoic acids, acyl 4 is tetradecanoic or (minor) hexadecanoic ... C-1, and was mostly present in an a-pyranose form. Acyl 1 ,acyl 2 and acyl 3 residues had hydroxy or acyloxy groups at C-3 ( 13 C signals of C-3 at 69.0–72.4 p.p.m.), while acyl...

Ngày tải lên: 08/03/2014, 09:20

... core-oligosaccha- rides of E. coli F653 LPS for which only preliminary data were available and investigated the deacylated LPS by NMR and MS. The proposed structure determined pre- viously by methylation analysis ... Verhoef, J. & Sinnwell, V. (1988) Iolation and chemical analysis of 7-O-(2-amino-2-deoxy-a- D -glucopyranosyl- L -glycero- D -manno-heptose as a constituent of the...

Ngày tải lên: 08/03/2014, 09:20

... Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system 7 Tatsuya 7 Kitazume 1 , Akinori Tanaka 1 , Naoki Takaya 1 , ... substrate-accessing channel, and their guanidinium and hydroxyl groups, respectively, play crucial roles in the binding of the substrate by interacting with the carboxyl group of the su...

Ngày tải lên: 08/03/2014, 22:20