Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... initiation and effector phase of allergic lung inflammation is independent of LT and CCL21. Materials and Methods Mice LT knockout mice (LT-KO) backcrossed to C57BL/6 were kindly provided by Dr. S. ... in the absence of secondary lymphoid tissue (in LTα knockout mice [40]). Thus, allergic lung inflammation can be generated independently of organized secon-dar...
Ngày tải lên: 03/11/2012, 11:24
... the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢- linked oligoadenylates, termed (2–5)A ... by thin-layer chromatog- raphy, immunologically and by high-performance liquid chromatography. The biological activity of (2–5)A oligo- mers was verified by inhibition of the protein s...
Ngày tải lên: 21/02/2014, 15:20
... examination of the colon remains to be the gold standard for diagno-sis, which is however invasive, unpleasant and carries associated risk of morbidity and mortality. Identifica-tion of high-risk ... biochemistry test. But, the sensitiv-ity and specificity of the current biomarkers in tumor diagnosis is low (usually less than 70%) and compli-cated by high return of ‘fals...
Ngày tải lên: 25/10/2012, 11:18
Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... study of the molecular mechanisms of action of this polymorphism. Because these results were based on the low frequency of A/A, they might be inconsistent due to the random errors. Studies of ... with the risk of Helicobactor pylori infection and gastric atrophy Yasuyuki Goto 1, Takafumi Ando 2, Kazuko Nishio 1, Sayo Kawai 1, Yoshiko Ishida 1, Mariko Naito 1, Hidemi Goto 2, Nobu...
Ngày tải lên: 31/10/2012, 15:37
Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx
... 17-OHPROG. Understanding of the complexity of hydroxylase and lyase activity of CYP17 by way of primary sequence alignments of CYP17 from different species has limitations. Even though CYP17 homology ranges from 65 ... biosynthesis of aldosterone, cortisol and androgens. The 17a-hydroxylation of the D 5 -andD 4 - steroids, pregnenolone (PREG) and progesterone (PROG), yield...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
... necessity for the accessory factors is likely due to poor DNA-binding af®nity of full-length Ets-1 rather than to poor potential of its activation domain. This is supported by the existence (at ... af®nity even in the absence of a ccessory factors. The auto-inhibitory domain is located within exon VII and a n alternative ly spliced form of Ets-1 t hat lacks this exon is cons...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt
... regions of dimyristoylglycerophosphoethanolamine and dimyristoylglycerophosphoglycerol membranes, P5 appeared to show deep penetration of both these latter membranes and dimyristoylglycerophosphocholine ... daphoenix@uclan.ac.uk Abbreviations:Myr 2 -PGro, dimyristoylglycerophosphoglycerol; Myr 2 -PCho, dimyristoylglycerophosphocholine; Myr 2 -PEtn, dimyristoylglycerophosphoethanolamin...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
... Germany; 2 Rutgers University, Department of Chemistry and Chemical Biology, Piscataway, NJ, USA Calcitonin (Ct) is a 32-residue peptide hormone that is mainly known for its hypocalcemic effect and ... acids and standard protection of the side-chains [Asp(OtBu), Glu(OtBu), G ln(Trt), Cys( Trt), H is( Trt), Lys(Boc), Tyr(tBu) and Thr(tBu)], with the exception of residues Lys2...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo y học: "Electronic patient record use during ward rounds: a qualitative study of interaction between medical staff"
... period of 13 months: 1month prior to deployment of the EPR, 4 months after deploy-ment of the EPR, and 1 year after deployment of the EPR.Each time, six separate, randomly selected patient discussionswere ... pertinent details of the patient and any recentchanges. The discussion that ensues is led by the consultantworking systematically through a number of issues, as appro-p...
Ngày tải lên: 25/10/2012, 10:31
Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... affluence and het-erogeneity of society. Most important to consider is “heterogeneity of society”. Mississauga is an ethni-cally diverse society where two or more cultures co-exist, this is considered ... Therefore, AUR and MISS were inde-pendently analyzed. Table 5: Cross cultural distributions of laughter and dis-ease patterns Level of laughter City Freq. of no disease...
Ngày tải lên: 26/10/2012, 09:57