... domainsother than the Gla domain on membrane binding, we havenow investigated the membrane-binding properties ofcoagulation factor X and Gla domain-containing frag-ments of this protein.MATERIALS ... protease (SP) domain [1]. The Gla-domain mediatesCa2+-dependent binding to biological membranes, forexample the platelet membrane [2]. Binding of factor X and other Gla domain-containing coagulation ... family of vitaminK-dependent proteins. It consists of an NH2-terminalc-carboxyglutamic acid (Gla)-containing domain, followedby two epidermal growth factor (EGF)-like domains and a serine...