... hypoosmotic hepatocyte swelling [12,13], insu-lin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition ... inhibition of autophagic proteolysis [14]. Thus, integrin-dependentcell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced ... signals involved in the regulation of metabolism, gene expression and the susceptibilityto different kinds of stress [6]. For example, the inhibi-tion of autophagic proteolysis by insulin, glutamineand...