Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... University of Jyväskylä, Jyväskylä, Finland 5. Division of Rheumatology, Department of Medicine, Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center, Hershey, PA, ... hepatocytes. We hypothesized that the cyto-toxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA- nicking and DNA- attaching activities of NS1. Upo...
Ngày tải lên: 25/10/2012, 11:18
Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"
... (Becton-Dickson), and statistical analysis completed by FlowJo software (Tree Star, Inc, Ash-land, OR). Cytotoxicity Assay. Trypan blue dye exclusion was used to determine cell viability. Adherent and loose ... efficiency analysis, 5 x 105 HepG2 cells were resuspended in 500 µL of ice-cold PBS and imme-diately analyzed by flow cytometry. For AnnexinV binding analysis 5 x 105 cells wer...
Ngày tải lên: 26/10/2012, 09:32
Báo cáo Y học: Mammalian mitochondrial endonuclease G Digestion of R-loops and localization in intermembrane space doc
... Kang 1 1 Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; 2 Department of Molecular Biology, Graduate School of Medical ... Sciences, Kyushu University, Fukuoka, Japan; 3 Department of Biochemistry, Faculty of Science, Okayama University of Science, Japan Mammalian mitochondria contain strong nucle...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 pot
... intracellular transport and protein degra- dation [2]. The biological consequences of molecular chaperone induction in many cell types involve not only repair of damaged polypeptides and cellular survival ... 5 and 6) in the absence of ATP, and DNA- binding reactions were analysed using native gel electrophoresis. (D) Analysis of E2F1 DNA binding using increasing concentr...
Ngày tải lên: 24/03/2014, 00:21
Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... torecognize and diagnose sepsis promptly because early diag-nosis and treatment may lead to improvement in both mortalityand morbidity [3]. An early diagnosis of sepsis before receiv-ing the results of ... T-helper lymphocyte type 2cytokine activation in response to sepsis after traumatic injury.Eosinophils normally account for only 1% to 3% of peripheralblood leucocytes, and the...
Ngày tải lên: 25/10/2012, 10:35
Báo cáo y học: "Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients"
... developed hypertension and subsequent tachycardia,tachypnea, and patient-ventilator asynchrony. Treatment withsedatives led to resolution of the hypertension and tachycar-dia, but the tachypnea and ... study entry, DIS and SA patients had sim-ilar RASS scores, were equally likely to be awake, and hadreceived similar doses of sedatives and opioids. Interim analy-sis was perfo...
Ngày tải lên: 25/10/2012, 10:35
Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... family history, ethnicity, increasing age, centralobesity, physical inactivity, low HDL/high triglycerides,fasting glucose of 110 mg/dL or greater, gestational diabe-tes, hypertension, and polycystic ... risk of type 2 diabetes mellitus, dyslipidemia,hypertension, stroke, ischemic heart disease and earlymortality [6-9]. The authors concluded that the preva-lence of obesity in this s...
Ngày tải lên: 25/10/2012, 10:51
Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"
... analysis of sol-id-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobilliary Pancreat Dis Int. 2008;7(2):196-200. 10. Yu CC, Yeh CN, Hwang TL, Jan YY. Clinicopathological study ... or tail of the pancreas. For tumors of SPT located in the neck and body of the pancreas, resection of the mid-portion of the pancreas and the mass with preserving the rim of th...
Ngày tải lên: 25/10/2012, 11:40
Báo cáo y học: " Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft"
... provided by systemic anti-biotic therapy and commonly available carrier sys-tems are insufficient in eliminating biofilm bacteria new ways of antibiotic delivery are required. The cri-teria of antibiotics ... with intracellular bactericidal activity and therefore should cover SCVs of staphylococci 35. It is likely to penetrate glycocalices very rapidly 36-38. Once incor-porated in b...
Ngày tải lên: 26/10/2012, 09:53
Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
... in vitro and in vivo. The activity of MMPs is increased by gene transcription, extracellular activation of the secreted inactive zymogen form, and reduced activity of tissue inhibitors of metalloproteinases. ... (intercellular cell-adhesion molecule 1) is associ-ated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: th...
Ngày tải lên: 26/10/2012, 10:03