... theantioxidant capacity of human serum, either directly or bybinding and carrying radical scavengers, or by sequesteringtransition metal ions with pro-oxidant activity. Finally, HSAacts as a nitric ... the binding isotherms of ferric haem to HSA in the absence and presence of ibuprofen and warfarin, asobtained by electronic absorption spectroscopy at pH 7.0 and 25.0 8C. Data analysis according ... the N-form [1,3,4,14,35,36]. Haem inhibitsdrug binding, possibly stabilizing the N-species of HSA(present study). Accordingly, binding of ibuprofen and warfarin to Sudlow’s site I impairs ferric...