Báo cáo khoa học: "Medical emergency teams: deciphering clues to crises in hospitals"

... theCommentaryMedical emergency teams: deciphering clues to crises inhospitalsMichael DeVitaAssociate Professor, Critical Care Medicine and Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, ... reliablyfind patients in crisis, which is an obviously dangeroussituation. To respond to this finding, a redesign is in order.Hospitals need some form of improved detection system,involving increased ... callsincrease during daylight hours because of an increase ininappropriate MET activations. Future studies will need toaddress this possible explanation.Jones and co-authors describe their findings in a...

Báo cáo y học: "Medical emergency teams and rapid response triggers - the ongoing quest for the ‘perfect’ patient safety system"

... the continuum of care, as opposedto a MET, which involves people who are unfamiliar withpatients’ pertinent medical conditions. These aspects shouldbe taken into consideration in the ongoing debate ... contributionsBoth authors contributed equally to the design and writing ofthis letter.Competing interestsThe authors declare that they have no competing interestswith regard to this manuscript.References1. ... have recently proposed an alternative model tothe MET, namely one based on defined clinical triggers toinitiate a rapid response escalation [2-4]. A clinical triggerssystem overcomes the ‘classic’...

Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf

... actor or director, allowing users to quickly navigate from an actor or director in a spe-cific title to other material they may be interested in. The buttons in the results panel can be pointed ... allowing the user to ‘glue’ together references to multiple actors or directors in order to constrain the search. For example, they can say “movies with THIS actor and THIS direc-tor” and point ... commands by combining the ease of reference of pointing with the expressiveness of spoken constraints. While by unimodally pointing at an actor button you can search for all of the ac-tor’s movies,...

Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"

... unwillingto continue life support after a reasonable trial hasdemonstrated that its benefit has passed the point ofdiminishing returns. However, there is a continuing trend ofsurrogates demanding ... 50:161-166.5. Crippen D: Terminally weaning awake patients from life sus-taining mechanical ventilation:the critical care physician’s rolein comfortmeasures during the dying process. Clin IntensiveCare 1992, ... ideal. This puts them in theposition of being buyers in a consumer’s market. Byasking them to make a choice, they imply that theirauthority to make choices extends to making bad ones.2. Moribund...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... a-synucleinalone (s, solid line), in the presence of100 lM neurotoxin (•, dotted line), in thepresence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and50 lM dopamine ... lM neurotoxin; lane 2, a-synuclein with 200 lM neurotoxin;lane 3, a-synuclein with 100 lM neurotoxin and 50 lM dopamine;lane 4, a-synuclein with 200 lM neurotoxin and 50 lM dopamine.P. N. ... pesticides including paraquat, rotenoneand dielderin have been shown to be potential inducersof a-synuclein aggregation [3]. More insight into therole of environmental toxin as a cause of Parkinson’sdisease...

Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

... having sufﬁcient power are thereforeextremely important in minimizing the in uence ofconfounding factors arising from inherent problemsassociated with breeding APP transgenic mice andmaintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages areautomated learning cages where animals carryingtransponders are housed in groups and trained in learning corners. Each individual ... thepathogenic interaction between Ab and a-synucleinwas investigated by crossing PDGF–a-synucleinand APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with...

Tài liệu Báo cáo khoa học: Enzyme kinetics informatics: from instrument to browser pdf

... also introduced the support of kinetic parame-ter submission. These input interfaces could in principleassist experimenters in submitting their kinetic data to the databases. However, entering ... sub-mitted from theKINETICSWIZARD. A cross-link to the corresponding experimental raw data in MeMo-RK is shown at the bottom.N. Swainston et al. Enzyme kinetics: from instrument to browserFEBS ... calculated.We here introduce an automated system to supportthe whole workﬂow of deriving kinetic data from thelaboratory instrument and make it accessible in theweb. The task of managing enzyme kinetics...

Tài liệu Báo cáo khoa học: Plasticity of laccase generated by homeologous recombination in yeast docx

... proteinutilizing the principle of protein–dye binding. AnalBiochem 2, 248–254.38 Bauer R & Rupe CO (1971) Use of syringaldazine in aphotometric method for estimating ‘free’ chlorine in water. ... sequence domain (blue cop-per-binding domain) that shares distant homology to the single-domain cupredoxins [21,22]. The evolution-ary path from a single-domain cupredoxin to a three-domain laccase ... variations in identity(for example ranging from 38–86% in Coprinopsis cine-rea [27]). This natural diversity within in a singleorganism can be used for protein engineering purpose. In Trametes...

Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf

... Igepal, 1% inhibitor coc-tail). To remove biotinylated surface proteins, cell lysatewas added to a streptavidin agarose resin and incubated for30 min. After centrifugation, only unlabelled intracellularproteins ... andlatency is maintained by an interaction between acystein residue in the prodomain and Zn2+ in theactive site of the catalytic domain. Two major types ofendogenous inhibitors regulate the ... cell-surfaceactivation in which proMMP-2 is activated in a trimo-lecular complex including membrane type 1 MMP(MT1-MMP) and the inhibitor TIMP-2, giving anMMP-2 intermediate that is autocatalysed to fullyactive...

Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efﬁcient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt

... triphosphate to the 5¢-hydroxyl group of thymidine, forming dTMP. Human TK1 iscytosolic and its activity is absent in resting cells, appears in late G1,increases in S phase coinciding with the increase ... lymphocytes in a total volumeof 200 lL was injected into a Superdex 200column (10 · 300 mm) together with 0.1mg Blue Dextran used as an internalstandard for determination of the voidvolume, V0, in ... myco-plasmic origin [14], the feedback inhibitor dTTP wasbound in the substrate pocket, similar to the bindingof dTTP to the D. melanogaster multi-substratedeoxyribonucleoside kinase [16], despite...

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