Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"

... variablesCommentaryMedical treatment for the terminally ill: the ‘risk of unacceptablebadness’David CrippenAssociate Professor, Director, Neurovascular ICU, Department of Critical Care Medicine, University of Pittsburgh ... in the death of a loved one. Once life-supporting care is instituted, the patient has options for survival’ that they did not have before, even though theyare dependent on ‘life support’. There ... end -of- life issues to patients and their families[11]. It is not uncommon for physicians to ask loadedquestions in their quest for end -of- life decisions. Forexample, ‘This is your grandmother’s...

Tài liệu Báo cáo khoa học: "Exploiting Structure for Event Discovery Using the MDI Algorithm" doc

... mention the pair of events.More formally, E = (S, s0, F, L, T) is a modelwhere S is the set of states, s0∈ S is the initial state,F ⊆ S is the set of ﬁnal states, L is the set of edgelabels ... is the set of transitions.We note that it is the responsibility of the learningalgorithm to discover the correct number of states.We treat the task of discovering an event model asthat of ... text, extract the relevant arguments of the event, and represent the extracted information intoa structured form (Grishman, 1997). The types of events to extract are known in advance. For exam-ple,...

Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt

... are tethered. Fur-thermore, this SrfA–C construct lacks the attachmentsite of the Ppant group (S1003A mutant) and shows the PCP on the acceptor site of the C-domain. The dis-tance of the S1003A ... comparison of the effect of compound 1 with that of the natural substrates ATP and l-Phe on the apo-and holo-forms of the A-PCP construct in the partialtryptic digest is shown in Fig. 2. The apo-form ... the investigation of the highly homologous protein tyrocidine synthetaseI (TycA) in its apo-form. They found that the addition of the substrates slowed down the proteolysis of the protein, mostly...

Báo cáo khoa học: "A System for Real-time Twitter Sentiment Analysis of 2012 U.S" pdf

... within each time period for each candidate. For volume, the system outputs the number of tweets every minute for each candidate. For sentiment, the system outputs the number of positive, negative, ... occurs. The dashboard gives a synthetic overview of volume and sentiment for the candidates, but it is often desirable to view selected tweets and their sentiments. The dashboard includes another ... whom remain in the running as of this writing. With this analysis, we seek to explore whether Twitter provides insights into the unfolding of the campaigns and indications of shifts in public...

Báo cáo khoa học: "Viterbi Training for PCFGs: Hardness Results and Competitiveness of Uniform Initialization" doc

... adjacent appearance of the rule V¯Yr→ 1 (because we parse substrings of the form 10), and then again we use the factthat all rules in the parse tree have probability 1. The case of VYr→ 0 and ... unsatisﬁable formula,using the reduction from §4 with the given algo-rithm, and identify whether the value of the objec-tive function is 1 or strictly less than 1. We get the result that:Theorem 4. The ... =ni=1fA(zi) (3)We use the following notation for G:• L(G) is the set of all strings (sentences) x thatcan be generated using the grammar G (the “language of G”).• D(G) is the set of all possible...

Báo cáo khoa học: Emerging tools for real-time label-free detection of interactions on functional protein microarrays ppt

... sensors. For all of these technologies, the magnitude of the change in the local index of refraction caused by bind-ing is a function of the mass and conformation of both the query molecule and the ... 60% of the mamma-lian proteins are expected to be expressed [41]. The concern is whether the quality of proteins from theseHT approaches will be sufﬁcient for functional assays. The capture of ... cause the cantilever to bend. In this illustration, the bending is detected optically by the displacement of a beam of lightreﬂected off the cantilever. Alternatively, the binding of the proteinmolecules...

Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx

... doi:10.1046/j.1432-1033.2003.03554.xhypothetical cascade of events initiated by ouabain occu-pancy of a small fraction of the sodium pumps. One of themhad advocated the role of EDLF for years [15].Possible pitfalls for a novel ... -insensitive a-isoforms of Na+/K+-ATPase in ratsAll isoforms of the catalytic a-peptide of Na+/K+-ATPasehave similar, high afﬁnity for ouabain [17] with Kdin the order of one or a few ... containinga1-aswellasa2-isoforms of Na+/K+-ATPase the explan-ation for the apparent signal-tranduction may differ [9–11].In one of the papers [9] it is mentioned that the rata1-isoform is less sensitive...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... synthesis is the carboxylation of acetyl-CoAto form malonyl-CoA, catalyzed by ACC – the key reg-ulatory enzyme in the pathway. Malonyl-CoA serves as the basic chain-elongating substrate for the formation of ... [13,23,28,30–33]. The genetic evidence for the role of AMPK in the hypothalamus is less clearbecause the loss of the AMPKa2 subunit in speciﬁchypothalamic cell types resulted in the opposite pheno-type ... mediators in the treatment of obesityFEBS Journal 278 (2011) 552–558 ª 2010 The Authors Journal compilation ª 2010 FEBS 555One of the biggest challenges to the ﬁeld is the lack of experimental...

Tài liệu Báo cáo khoa học: Kinetic basis for linking the ﬁrst two enzymes of chlorophyll biosynthesis doc

... methyltransferasesteps. The KD for the H ⁄ ID interaction wastaken from Jensen et al. 1998 [24], and the KD for the association with ChlM is fromFig. 1. The possible effects of varying the concentration of the ... better estimate of intermediateaccumulation, as the ﬁt in Fig. 3B considers only the evolution of intermediate. The rate constant for the decay of intermediate in the presence of ChlH(31.7 ± ... greatly inﬂuence the cata-lytic rate of CHLM, the eukaryotic MgP methyl-transferase. This has important implications for the coupling between these steps and for the availability of MgP for signalling....

Tài liệu Báo cáo khoa học: "Unsupervised Search for The Optimal Segmentation for Statistical Machine Translation" doc

... occurrence of twophrase pairs in a Turkish-English parallel corpusand the two hypothesized sets of segmentations for the Turkish phrases as in Table 1. Without ac-cess to the English side of the ... to the next. The incremental updates are derived from the equations for the count collection and probabilityestimation steps of the EM algorithm as follows.In the count collection step, in the ... if they already exist.Then in the probability estimation step, the nor-malization is performed including the newly addedfractional counts.3.2 Parallelization of searchIn an iteration of the...

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