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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... formation. Fig. S3. Co-immunoprecipitation of TIAR with ASF ⁄ SF2 mutant lacking the RS domain. This supplementary material can be found in the online version of this article. Please note: As a service ... study on this TIAR-interacting can- didate. Figure 3A shows that endogenous ASF ⁄ SF2 protein co-immunoprecipitates with TIAR-Flag. We then determined whether ASF ⁄ SF2 could be...
Ngày tải lên: 16/02/2014, 15:20
Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... degradation in cultured human cells. Discussion We have shown that the selective knockdown of HO-2 expression with each of two different siRNAs is consis- tently associated with increased expression of ... be noted, however, that heme activates the HO-1 gene promoter [40], but the relevant cis-acting element is not present in the 4.5-kb promoter region. It is therefore conceiv- ab...
Ngày tải lên: 19/02/2014, 05:20
Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... iden- tical to those of the unstimulated cells. This view is consistent with a previous report showing that MDP, but not a safe analogue such as MB, is capable of inducing mitochondrial proton leak ... MDP. The question raised at this stage is whether UCP2 is responsible for the increase in mitochondrial proton permeability (state 4) induced in macrophages after stimulation wit...
Ngày tải lên: 05/03/2014, 23:20
Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... long-term treatment of cells with ST. As the 130 kDa form of GC-C is still on the surface after prolonged ST treatment, it is not clear at this time whether the 130 kDa form alone is recycled, or not internalized ... blot analysis with strept- avidin–peroxidase. Results Homologous desensitization of GC-C in Caco2 cells We studied this phenomenon of GC-C desensitization in Caco2...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... an (N,N-dimethylacetimidoyl)amino group is presen t (Fig. 8, structure 2). This group is linked to C5 of a legionaminic acid residue, which is substituted with a nonmethylated N-acetimidoyl group ... erum resistance were not affected in mutant 5215, when compared to the parental wild-type RC1 (data not shown), which revealed that t he mAb 2625 LPS epitope it self is not associate...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... bikunin expression is associated with a less malignant phenotype [24]. There is evidence that bikunin significantly prevented pulmonary metastasis of mouse Lewis lung carcinoma 3LL cells [55]. Our ... 10 n M (data not shown). Equivalent K d value was determined ( 1.6 n M ), which is consistent with the known binding affinity of uPA for uPAR [5]. In cells treated with PMA, cell -a...
Ngày tải lên: 17/03/2014, 11:20
Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... affect the activity [10,11,19], mutagenesis at this region in Lqh3 had no effect (Table 1), suggesting that this structural motif was not involved in direct contact with 1.0 0.8 0.6 0.4 0.2 8.07.57.06.5 pH 0.0 Lqh3 E10Y-E63R 1.0 0.8 0.6 0.4 0.2 0.0 [Toxin] ... Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv- ity to pH, substitutions of His66 had a clear im...
Ngày tải lên: 23/03/2014, 09:20
Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... treated with oligomy- cin causes an immediate and precipitous opening of the PTP. As shown in Fig. 2A, this was not observed in mitochondria isolated from embryos of A. francis- cana. It is of note ... that exogenously added adenine nucleotides decrease Ca 2+ uptake rate and capacity in mitochondria isolated from embryos of A. franciscana, a phenomenon that is apparently at odds with...
Ngày tải lên: 29/03/2014, 00:20
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