what kind of weather is associated with nimbostratus clouds

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Ngày tải lên: 13/08/2014, 20:21

... models with a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso- lated a missense ... 5’-flanking region of the NPPB gene was discovered. This poly- morphism was associated with EH in female subjects. However, this finding does not necessarily imply that there is a relationship ... accession number AB265677). This VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TTTC (Fig. 1A). There were 8 alleles of this VNTR polymorphism, ranging from 9-repeat to...

Ngày tải lên: 26/10/2012, 10:04

... control of gene expression. As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and transla- tion rate is essential for the control of the expression of ... and reflect the capacity of TIAR to be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP M and ASF ⁄ SF2 are associated with TIAR by protein– protein ... family of RNA-binding-proteins. It is a shuttling protein [5] involved in multiple aspects of RNA metabolism. In the nucleus, this protein acts as a regulator of the alternative splicing of diverse...

Ngày tải lên: 16/02/2014, 15:20

... cultured human cells. Discussion We have shown that the selective knockdown of HO-2 expression with each of two different siRNAs is consis- tently associated with increased expression of HO-1 mRNA and ... influence the expression of HO-1. The dominant expression of HO-2 protein, in comparison with the low expression of HO-1 protein, in H146 small cell lung cancer cells is of particular interest ... It is the MARE site that is bound by Nrf2, a transcription activator, or Bach1, a transcription repressor, each of which functions as a heterodimer with a member of the Maf family [46]. Bach1 is...

Ngày tải lên: 19/02/2014, 05:20

... as MB, is capable of inducing mitochondrial proton leak in the spleen and liver of injected mice. Moreover, it is of importance to note that the maximum in vivo effect of MDP and some of its ... infections, potentiation of anti-tumour activity of macrophages, manipulation of cytokine release and restoration of haematopoiesis [18–20]. The parent molecule of this family is muramyl dipeptide (MDP), which ... effects with those of the parent molecule MDP. The results reported establish the safety of MB, the absence of undesirable effects on the central nervous system, and the lack of induction of inflammatory...

Ngày tải lên: 05/03/2014, 23:20

... absence of differentially glycosylated forms of GC-C. It is possible that the reappearance of the 145 kDa form following removal of ST peptide was a consequence of further glycosylation of the ER -associated ... The absence of GC-C desensitization (which is correlated with removal of the 145 kDa form of GC-C from cells) in HEK293-GC-C cells could be due to lack of a cellular factor that is present in T84 ... long-term treatment of cells with ST. As the 130 kDa form of GC-C is still on the surface after prolonged ST treatment, it is not clear at this time whether the 130 kDa form alone is recycled, or...

Ngày tải lên: 08/03/2014, 08:20

... of only one isomer. Molecular modelling data ( not shown) suggested t hat this isomer is 2-E with trans orientation of N 1 to C5 as 2- Z would be s terically hindered b y interaction of one of ... stereoisomerism). The lower-đeld 1 H NMR signal of 3 belonged to the N-methyl group at N 2 in the E isomer and t he higher-đeld signal t o that in t he Z isomer, in which N 1 is in trans and cis ... careful NMR spectroscopic analysis was used to elucidate the structure of N-methylated derivatives of legionaminic acid. Comparison of the 1 H N MR spectra of the OPS of pool III from all three investigated...

Ngày tải lên: 08/03/2014, 10:20

... possibly through suppression of upstream targets of ERK. Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulat- ing uPAR. It is most likely that the PMA-induced ... invasiveness is a complex, multistep process that involves cell attachment, the proteolysis of matrix compo- nents, and the migration of cells through the disrupted matrix [1]. Activation of receptor-bound ... invasion and metastasis [2]. In a number of cancers, the expression of the uPA and uPAR is required for the invasive phenotype [3,4]. uPAR binds uPA with high affinity with a K d of  0.5 n M [5,6]....

Ngày tải lên: 17/03/2014, 11:20

... FEBS His15 and His66 seem to contribute to the differential interaction of Lqh3 with channel receptors of various origin. In total, the bioactive surface of Lqh3 is composed of two distinct ... 6B). Discussion Insight into the molecular basis of preferential interac- tions of scorpion a-toxins with insect or mammalian Na v s was thus far obtained mainly from mutagenesis and comparison of ... 3). Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv- ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R (Table 3). Unexpectedly,...

Ngày tải lên: 23/03/2014, 09:20

... alignment of the Artemia ANT p rotein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms 1 and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms ... compared with the known structure of bovine ANT. Comparison of the predicted three-dimensional structure of Artemia ANT with that of bovine ANT The structure of bovine ANT (isoform 1) is known (structure: ... mitochondria isolated from embryos of A. francis- cana. It is of note that, in the presence of oligomycin and ADP, addition of Ca 2+ failed to induce an increase in light scattering (Fig. 2A), consistent...

Ngày tải lên: 29/03/2014, 00:20

... phosphorylation of this residue in the inhibitory regulation of GC-A activity. To follow this hypothesis, we tested the influence of the substitution of Ser487 with glutamate on the pro- cess of homologous ... top). This suggests that this phosphorylation site, in contrast with the others, is phosphorylated during homologous desensitization. Hence, homologous desensitization of GC-A is associ- ated with ... accomplished using multiquant 1.0 software (Applied Biosystems) [33]. Esti- mates of the relative abundance of phosphorylated tryptic peptides of GC-A isolated from HEK293 cells treated with ANP...

Ngày tải lên: 29/03/2014, 09:20

... pathway [14,15] and its loss is associated with ErbB2 ⁄ HER-2 oncogenic potency leading to Herceptin resistance [16]. Furthermore, its overexpression is associated with down-regulation of phosphorylated-ErbB2 ... transcriptional regulation of this mutant is of clinical importance in terms of con- tributing towards our understanding of patient sensi- tivity to Iressa, as well as side effects and drug resistance. The ... factor receptor (EGFR) is a mem- brane tyrosine kinase that is involved in the regulation of a wide variety of biological processes [1]. Controlled activation of EGFR is systemically and evolutionarily guaranteed...

Ngày tải lên: 30/03/2014, 01:20

... percentage of CD133 + tumor cells and the prognosis of colorectal cancer patients. This study showed that the percentage of CD133 + tumor cells was associated with the prognosis among patients with ... function of CD133 is unknown, preliminary evidence proposed that expression of CD133 is associated with the activation of stemness-related signal pathway, resistance to apopto- sis and bioenergetic ... percentage of cancer stem cells is associated with the prognosis of cancer patients, the over- population hypothesis would be substantially supported. By now, the relationship between the percentage of CD133...

Ngày tải lên: 18/06/2014, 15:20