... propensity of the N-(+7)Ala variant to adopt the b-cross state. Fibrils of N-WT and N-(+7)Ala alsodiffer with respect to the fibril growth rates. In the case of N-WT, the conversion to the fibrillar confor-mation ... Becausefibril formation, like other aggregation processes, isknown to be a concentration-dependent reaction, the absence of nuclear inclusions in the case of thesemutants may simply be due to the fact ... confor-mation is presumably very slow under the appliedconditions. This assumption, and the fact that seedslose their activity upon incubation, may be responsiblefor the only moderate acceleration of...