... genomic DNA preincubated with three differ-ent concentrations (1, 50 and 150 lM) of spermine (lanes c, c¢ andc¢¢), spermidine (lanes d, d¢ and d¢¢) or putrescine (lanes e, e¢ ande¢¢) and then exposed ... polyamines, mainly spermine, can modulatethe DNA-binding properties of proteins, either increas-ing or diminishing their affinity for DNA [42]. Thisability, to modulate the DNA-binding properties ... supramolecularstructures that play a crucial role in genomic DNAprotection and conformationLuciano D’Agostino1, Massimiliano di Pietro1and Aldo Di Luccia21 Department of Clinical and Experimental Medicine, ‘Federico...