... factor (NGF) and neurotrophin (NT)- 3, 4/5, play an important physiological role in the maintenance and growth of neurons and synaptic plasticity in the adult brain (Lewin and Barde 1996) and ... been confirmed in postmortem, serotonin transporter, serotonin receptor and cerebrospinal fluid (CSF) studies and neuroendocrine challenge tests. Post-mortem studies of the brains of suicide ... serotonin dysfunction appears to be localized to the ventral prefrontal cortex, a region that is involved in behavioral and cognitive inhibition. Thus, low serotonergic input may contribute to...