... potency of < /b> alpha-thrombin and thrombin -receptor-< /b> activating peptide on human platelets < /b> – < /b> concentration and time effects of < /b> thrombin-induced Ca2+ signaling < /b> Eur J Biochem 249, 54 7–5 < /b> 55 45 Goncalves ... (autocrine) ADP, acting via P2Y12,< /b> enhances and extends the thrombin-induced platelet activation by increasing Ca2+ mobilization from internal stores, without directly affecting a speci c Ca2+ ... resulted in < /b> a 61 ± 10% increase of < /b> InsP3-induced Ca2+ mobilization Together, these results show that P2Y12 < /b> receptor < /b> activation, by lowering cAMP and PKA activity, can enhance the Ca2+- mobilizing function...