... cytotoxic drugs by increasing the sensitivity of the tumors to these agents Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the alkylating ... mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and not directly damage DNA, PARP-1 inhibitors might be both safe and...
Ngày tải lên: 31/10/2012, 16:57
... the duration of the effect depends on the rate of enzyme resynthesis Furthermore, salicylate may contribute to the effect ASA irritates the gastric mucosa (direct acid effect and inhibition of ... secretion PG promote the production of gastric mucus and reduce the formation of gastric acid (p 160) Menstruation PGF2! is believed to be responsible for the ischemic ne...
Ngày tải lên: 24/10/2013, 19:15
Tài liệu Global Initative For Asthma doc
... recommendations for asthma programs Global Strategy for Asthma Management and Prevention GINA Executive Summary Eur Respir J 2008; 31: 1-36 Pocket Guide for Asthma Management and Prevention for Adults ... resources The Global Initiative for Asthma program publications include: CO PY RI G HT E D MA TE RI A L- Global Strategy for Asthma Management and Prevention (201...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION pdf
... Global Strategy for Asthma Management and Prevention The GINA reports are available on www.ginasthma.org Global Strategy for Asthma Management and Prevention 2006 GINA EXECUTIVE ... available and therefore the preferred treatment for acute asthma in children of all ages ASTHMA MANAGEMENT AND PREVENTION To achieve and maintain asthma control for...
Ngày tải lên: 21/02/2014, 12:20
Tài liệu Một số thuốc mới chống rối loạn lipid máu (New drugs for the control of dyslipidemia) pdf
... Cmax, giảm dao động hấp thụ thuốc ảnh hởng thức ăn tăng 25% sinh khả dụng Mong thông tin cập mang lại niềm vui cho bệnh nhân bị rối loạn lipid máu Tài liệu tham khảo Tài liệu khoa học công ty dợc ... đợc pha lipid thành mạch, vitamin E chống chọi với oxy hoá LDL chống tác hại gốc tự nội bào * Bình rợu cũ Fenofibrat (liphanthyl) từ lâu đợc dùng phổ biến để điều chỉnh ng...
Ngày tải lên: 26/02/2014, 03:20
Programmatic update Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants pptx
... resistance in women due to poor adherence and in infants infected despite maternal ART, and the acceptability and feasibility for women of remaining in care and on lifelong ART, especially for women ... drugs for treating pregnant women and preventing HIV infections in infants: recommendations for a public health approach, 2010 version Geneva,...
Ngày tải lên: 08/03/2014, 15:20
Guidance for Industry Acute Bacterial Sinusitis: Developing Drugs for Treatment ppt
... Guidance for Industry Acute Bacterial Sinusitis: Developing Drugs for Treatment Additional copies are available from: Office of Communications, Division of Drug Information Center for Drug ... 17 Contains Nonbinding Recommendations Guidance for Industry1 Acute Bacterial Sinusitis: Developing Drugs for Treatment This guidance represents the Food and D...
Ngày tải lên: 31/03/2014, 14:21
Báo cáo y học: "Determinants in early life for asthma development" docx
... present with allergic symptoms very early in life [2,3] Determinants in early life for asthma development Since asthma (i.e recurrent wheezing) constitutes different types, it is very difficult to predict ... hyperreactivity, which is a predisposing situation for severe viral-induced wheezing during years [9] Viral respiratory infections RSV lower respiratory tract illness...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: " Interleukin-17 regulation: an attractive therapeutic approach for asthma" potx
... WL, Hong HY, Yao YS, Han P, Li ZK, Wang GL, Cao Y, Liu XR, Wang JC, Zhang X, Zhang Q: Pharmacokinetics and anti-asthmatic potential of non-parenterally administered recombinant human interleukin-1 ... become an important target for the development of therapeutic modalities for the disease Therefore, the discovery of new cytokine can afford other opportunity to control the inflammator...
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: " A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression" pdf
... expression Data from all these assays together suggest that the effect of glucocorticoids on asthma may partly pass through the PTEN signaling pathway, and that PTEN is a new target gene involved in the ... Because of these facts, PTEN has been proposed as a therapeutic target for asthma [16] PTEN acts as the catalytic antagonist of PI3K by dephosphorylati...
Ngày tải lên: 12/08/2014, 13:22
Báo cáo y học: "High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial" pptx
... this article as: Mahajan et al.: High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial Respiratory ... abbreviations BMI: Body mass index; COAT Trial: Chest Wall Oscillation for Asthma and COPD ExacerbaTions Trial; COPD: Chronic obstructive pulmonary...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... circulating cytokine, coupled with the high specificity and high affinity of binding for the cytokine, makes the soluble receptor ideal as a cytokine antagonist Soluble recombinant human IL-4 receptor ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma" ppsx
... genes, such as those for cytokines, growth factors, and receptors, that are potentially involved in airway inflammation and atopic asthma [10] Structural analyses of these candidate genes have identified ... Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA: Genetic variants of IL-13 signalling an...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "clinical review: Devices and drugs for cardiopulmonary resuscitation – opportunities and restraints" pot
... waveforms and allow lower energy defibrillation, which minimizes myocardial injury and the severity of the newly identified condition ‘postresuscitation myocardial dysfunction’ [13,14] Postresuscitation ... progressively impaired over an interval of hours, with gradual recovery over the following days [20] The severity of postresuscitation myocardial dysfunction is minimized by early res...
Ngày tải lên: 12/08/2014, 20:20