... Comparisons of CENP-C proteins in animals, yeast and plants The CENPC motif and conserved regions found at the termini of CENP-C proteins are indicated For pairwise comparisons of protein-coding sequences, ... DNAbinding proteins would maintain an interface with the conserved kinetochore machinery Indeed, regions of CENP-C that show evidence of positive selection include DNAbinding and specificity regions, in ... adaptive evolution of DNA-binding specificity in these regions Targeting of native CENP-C proteins depends on other centromere proteins that vary according to species [45], but the dependence of CENP-Cs...