... isomers of retinol and retinal, including the 11 -cis-retinoids involved in photosensitivity Kinetic properties and its localization in many retinal cell layers support the involvement of ADH4 in the ... notably increased in the docked 11-cis-retinal, suggesting that the distinct location of the substrate in the binding pocket of ADH4 is the reason for the low activity observed with this retinal ... enzyme [31,42] Kinetic constants with retinoids Kinetic constants with all-trans-retinol and all-trans-retinal, and with the cis-isomers of retinol and retinal (7-cis-, 9-cis-, 11-cis- and 13-cis-),...