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... half-time for binding to the Characterization of the binding of PCSK9 to intact cells Fig Nonlinear regression and Scatchard analyses of binding- inhibition data (A) Inhibition of [125I]TC-PCSK9 (2.5 ... binding to HepG2 cells To determine whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simple bimolecular reaction, the...

Ngày tải lên: 14/02/2014, 14:20

... Matteı et al ¨ Membrane targeting and pore formation by the T3SS Host membrane Translocon Needle A Bacterium B C D Translocators Fig Schematic diagram illustrating needle and translocon formation, ... formation of the Pop translocon on the eukaryotic membrane, toxins produced in the bacterial cytoplasm release their cognate chaperones and are injected throu...

Ngày tải lên: 14/02/2014, 22:20

... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context...

Ngày tải lên: 16/02/2014, 09:20

... Roles of prostaglandin D2 in adipogenesis in vivo Y Fujitani et al indicate that overexpression of H-PGDS increases insulin sensitivity in vivo Adipocyte differentiation ex vivo Finally, we examined ... of WT mice Serum levels of triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG mice After weeks of normal or HF diet, serum leve...

Ngày tải lên: 16/02/2014, 09:20

... (Y1 , Y2 , Y4 , Y5 and y6 ) that vary in their binding profiles and in their distribution in the central nervous system and periphery Y1 , Y2 and Y5 are the best characterized NPY receptors, and the ... debatable whether the effect of Y1 results only from local production of NPY Thus, further studies are needed to fully assess the direct role of NPY and Y1 in b...

Ngày tải lên: 18/02/2014, 04:20

... 490– 500 Wolthers KR & Scrutton NS (2007) Protein interactions in the human methionine synthase methionine synthase reductase complex and implications for the mechanism of enzyme reactivation ... of MS During primary turnover, the homocysteine-binding domain (dotted barrel) and the CH3-H4-folate binding-domain (black barrel) form discrete complexes with the co...

Ngày tải lên: 18/02/2014, 08:20

... (2008) A novel plant protein disulfide isomerase family homologous to animal P5 – molecular cloning and characterization as a functional protein for folding of soybean seed-storage proteins FEBS J ... both luminal proteins Generally, PDI family proteins play important roles in folding and quality control of nascent polypeptides [25] In soybean cotyledon, lar...

Ngày tải lên: 18/02/2014, 11:20

... H Shimano Physiology and pathophysiology of the SREBP family SREBP- 1c and lipogenesis The SREBP family consists of three isoforms: SREBP1 a, SREBP- 1c, and SREBP- 2 Each isoform has a different ... Physiology and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-...

Ngày tải lên: 18/02/2014, 13:20

... 2008 The Authors Journal compilation ª 2008 FEBS 6061 DSPs and the cytoskeleton C Vale and L M Botana Diarrheic shellfish toxins and cell adhesion The adherence of cells to each other and to the ... dinophysistoxins and analogs) affect Ser ⁄ Thr protein phosphatases and their effects on cell adhesion and cytoskeletal dynamics, the disruption of which is linked to lo...

Ngày tải lên: 18/02/2014, 14:20

... believed that the role of this system was mainly structural, providing the support needed to maintain the shape and organization of the cell and the scaffolding for the actions of catalytic molecules ... C Louzao et al Distortion of the Na+ pump At the cellular level, a broad range of studies have indicated that the Na+ pump or Na+ ⁄ K+-ATPase is the higher...

Ngày tải lên: 18/02/2014, 14:20

... monomeric actin and actin severing because of the rapid depolymerization that they induce [31,34] However, jasplakinolides induce actin polymerization, stabilizing actin filaments and actin nucleation ... between the PTX-bound actin monomer and the lower lateral actin monomer within the filament, thereby capping the barbed end without inducing filament severing, e...

Ngày tải lên: 18/02/2014, 14:20

... 2007 FEBS 4087 SmSmad1B, a BMP -R-Smad ortholog from S mansoni J M Carlo et al enhanced the interaction of SmSmad2 and SmSmad4 and resulted in the formation of a stable and functional Smad complex ... degree of homology with BMP-related R-Smads (Smads 1, and ⁄ 9) from different species Smad5 orthologs from the domestic dog (Canis familiaris), the common chimpanzee (Pa...

Ngày tải lên: 18/02/2014, 16:20

... Crystal structure of E53QbsSHMT and its complexes Table Data collection statistics of E53QbsSHMT and its complexes Values in parantheses correspond to highest resolution bin Ligand(s) used None Gly ... belonged to the P21212 space group and contained one monomer in the asymmetric unit Cell dimensions and details of data collection are shown in Table Expression and purificat...

Ngày tải lên: 18/02/2014, 16:20

... (0.04) (0 .19 ) (0.09) 19 83 2493 14 86 18 85 10 30 16 30 13 45 10 38 19 60 805 514 (406) (13 74) (780) ( 710 ) ( 613 ) (809) (740) (542) (10 47) (752) (277) 19 64 15 61 1008 15 96 905 12 97 11 42 468 14 03 276 206 ... S1 Bar graph of R1, R2 and {1H} 15 N NOE values along the sequence of the TTF1 HD at 11 .7 T and 286 K 448 Fig S2 Plot of J(0.87xN)–J(0) correlati...

Ngày tải lên: 18/02/2014, 16:20

Ngày tải lên: 18/02/2014, 17:20