The Detective and the Author: City of Glass
Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf
... mentioned The mail- coach system had its origin in the West of England, and Bristol and Bath in particular are associated with all the traditions of the initiatory stages, so that the details on ... was at the same time so cheap that the cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the toast of "the Visitors," and said that they had ... FREELING, MAIL AND COACH ADMINISTRATORS On the 25th April, 1901, the day after a visit to Bristol to celebrate the establishment of the new steamship line to Jamaica, the Marquess of Londonderry, then...
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Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
... axon terminal in the sinus gland, as a result of late and progressive isomerization of the Phe3 of the CHH during the migration of the secretion vesicles along the axonal tract [39,41] The immunohistochemical ... (vitellogenesis inhibiting hormone) and CHH (crustacean hyperglycemic hormone) of the crustacean have the same precursor? Immunolocalization of VIH and CHH in the X-organ sinus gland complex of the lobster ... microscopy study of the neuronal endings in the sinus gland to determine the subcellular localization of the different epimers Taken together, these results allow a discussion of the existence of enzyme(s)...
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf
... evaluate the effects of ionic strength and Mg2+ on the activity and specificity of OGG1, we measured the apparent values of k2 and k3 under conditions of low salt (KPi only) and no Mg2+, low salt and ... Effects of ionic strength and divalent cations on the activity and specificity of Fpg and OGG1 The conditions inside a living cell differ from most buffer systems in which the activity and specificity ... may be affected by ionic strength, the concentration of divalent cations such as Mg2+, the nature of the buffering agents, the presence of competing polyamines and other small molecules, and crowding...
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Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... determined with the free somatic form using inhibitor profiles (Tables and 2) validates the use of selective inhibitors as convenient tools to study the specificity of the somatic form of ACE Thus, ... were applied to the atomic position of several sets of atoms The harmonic constants were set to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and their chelating residues, the ˚ atoms of the protein ... distance greater than A 1780 of the inhibitor, and the backbone and Cb atoms of the inhibitor and those of the protein located at a distance ˚ smaller than A of the inhibitor, respectively No harmonic...
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Báo cáo khoa học: The specificity of alcohol dehydrogenase with cis-retinoids Activity with 11-cis-retinol and localization in retina docx
... isomers of retinol and retinal, including the 11 -cis-retinoids involved in photosensitivity Kinetic properties and its localization in many retinal cell layers support the involvement of ADH4 in the ... notably increased in the docked 11-cis-retinal, suggesting that the distinct location of the substrate in the binding pocket of ADH4 is the reason for the low activity observed with this retinal ... enzyme [31,42] Kinetic constants with retinoids Kinetic constants with all-trans-retinol and all-trans-retinal, and with the cis-isomers of retinol and retinal (7-cis-, 9-cis-, 11-cis- and 13-cis-),...
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Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt
... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of substrate specificity Inspection of the substrate ... surrounding the binding pocket The two complexes were very similar In both structures, the largest contacts were found between the plane of the substrate ring and the plane of the imidazole ring of residue...
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Báo cáo khoa học: Determination of the metal ion dependence and substrate specificity of a hydratase involved in the degradation pathway of biphenyl/chlorobiphenyl pot
... substrate Therefore, the metal ion has a catalytic rather than just a substrate binding role Possible roles of the cation include the activation of water for the hydration reaction and ⁄ or the ... stabilization of the anion transition state In the latter case, if the substrate coordination to the metal ion is not bidentate, interaction of the single metal ion in the active site with the ... pathway [5] The binding of divalent cations by the decarboxylase precludes metal binding studies of the hydratase in that complex In this study, BphH, the hydratase in the PCBs degradation pathway...
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The lost city of machu picchu
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Báo cáo khoa học: Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase pptx
... (1983) Directed mutagenesis of dihydrofolate reductase Science 222, 782–788 Hartman PG (1993) Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors J Chemother 5, 369–376 ... Barrow WW (1998) Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase J Antimicrob Chemother ... Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH J Biol Chem 265, 5579–5584 19 Birdsall B, Andrews...
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Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt
... discrimination We anticipate that the performance of the potential will only increase with the size of the structural database and as terms are added to the model to account for protein and RNA intra-molecular ... structural data available for training Nevertheless, the distancedependent potential function already performs on par with the amber and rosetta force fields in decoy discrimination tests The impact of ... less favorable statistics (fewer structures of protein–RNA complexes) We anticipate that the increasing availability of protein– RNA structures, together with the availability of data on specificity, ...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... 4¢-phosphopantothenoylcysteine synthetase CoaB (Eur J Biochem 271) 169 Fig Analysis of the enzymatic activity of His -CoaB R206Q and A276V The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of the figure) and ... important for the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in binding of one of the substrates, the amino acid cysteine (Fig 3) However, it ... a group of NAD-dependent enzymes on one hand and with the ribokinase fold on the other hand The structure of the human PPC synthetase complexed with substrates, the cosubstrate ATP or the intermediate...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... considers the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II ... activity of the Asn14 9Asp variant, it is clear that the interactions of arginase II with l-arginine and agmatine are greatly altered by replacement of this residue with aspartate To the best of our ... mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn mutations on the interaction of the enzyme with manganese ions, maximally...
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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx
... NADP+ can arise If we assume the use of a commercial NADP+ containing 0.3% NAD+, as in the case of the Roche sample used in this study, then in a steady-state assay, as in the rapid-reaction ... reaction of wild-type clostridial glutamate dehydrogenase with NADP+ (A) The main panel shows the reaction of 15 lM glutamate dehydrogenase with mM coenzyme and 40 mM L -glutamate (concentrations ... both NAD+ and NADP+ as coenzymes, though less marked than for the other mutations, and at pH 8.0 with NADP+ as coenzyme there was little difference between the performance of the wild-type and...
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A Concise History and Directory of the City of Norwich for 1811 pptx
... filled, appears to the best advantage, and then any person who has a taste for theatrical amusements, neatness and elegance, cannot fail being agreeably entertained with the appearance of the audience, ... A Concise History and Directory of the City by C Berry A CONCISE HISTORY AND DIRECTORY OF THE CITY OF NORWICH; For 1811: Containing besides the LISTS, A VARIETY OF LOCAL INFORMATION, USEFUL and ... Robert and Thomas Cooke, Esqrs for the habitation of 10 poor women being 60 years of age or upwards, of good character, and who had been inhabitants of the city at least 10 years Each of them in addition...
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Từ khóa: the capital city of the cakchiquelsfill in the blank city offamily feud fill in the blank city ofmanaus the capital city of the state of amazonas brazilin the market place in the latvian city of rigathe assassin and the empire a throne of glass novellaNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015