Nonsense mediated decay in beta thalassemia

... hemoglobin The globin chain of hemoglobin is made up of four protein chains that are arranged in matching pairs These chains can be categorized into two families, namely the alpha globin and beta ... level of PTC-containing transcripts in 50 HeLa cells 3.2 mRNA decay rate for PTC-containing transcript in HeLa Tet-Off system 53 3.3 mRNA decay rate for PTC-containing transcript in...

Ngày tải lên: 27/11/2015, 11:11

... The presence and efficiency of NMD was investigated in Y lipolytica Homologs of UPF1 (YlUPF1, YALI0D23881g) and UPF2 (YlUPF2, YALI0E24629g) were detected in the Y lipolytica genome by searches ... efficiency of splicing factor recruitment during transcription may influence splicing efficiency [80] and that the carboxy-terminal domain (CTD) of the large subunit o...

Ngày tải lên: 09/08/2014, 20:22

... for a complex transcriptome is still costly, and assembly of the data is still computationally intensive Since tiling arrays and sequencing have complementary benefits for transcriptome analysis, ... pathways [8,9] Recently, genome-scale tiling arrays and massively parallel sequence analysis of transcriptomes have emerged as powerful new tools for transcriptome analysis [10-...

Ngày tải lên: 09/08/2014, 20:20

... of HSV-2 in vaginally-infected mice was prevented by intra-vaginal application of purified TLR ligands [12,13] Similarly, intravenous injection of ligands for TLR3, -4, -5, -7, and -9 inhibit ... TLR3 and TLR4 ligands induced secretion of IFNβ that inhibited HCMV infection of HFF Figure and lasts Poly I:C LPS induce IFNβ secretion by Foreskin FibrobPoly I:C and...

Ngày tải lên: 20/06/2014, 01:20

... can be expected, promoting NMD to a gene-expression tool with many utilities The cellular vacuum cleaner has therefore become a Swiss army knife (Figure 1) In silico veritas? In a series of three ... receptor J Neurosci 1999, 19:5348-5359 Wollerton MC, Gooding C, Wagner EJ, Garcia-Blanco MA, Smith CW: Autoregulation of polypyrimidine tract binding protein by alternative splicing l...

Ngày tải lên: 09/08/2014, 20:20

... article as: Ishaq and Shabbir: Takayasu’s arteritis presenting with temporary loss of vision in a 23-year-old woman with beta thalassemia trait: a case report Journal of Medical Case Reports 2011 5:466 ... is an essential part of managing such patients in our setting, where beta thalassemia trait testing is not done routinely Conclusion The simult...

Ngày tải lên: 10/08/2014, 23:20

... amyloidogenic intermediate [12,29], present different conformations of the D-strand: a regular D-strand (in the P32A mutant) [12] and a bulged D-strand (in the hexa- Amyloid propensity in b2m D53P ... Amyloid propensity in b2m D53P S Azinas et al Introduction Intermolecular cross-b interactions are at the basis of protein amyloid aggregation In the cross-b structure,...

Ngày tải lên: 06/03/2014, 00:20

... growth in the cold Surprisingly, however, the cold sensitive phenotype in atf1– or pcr1– strains is not shared by mutants disrupted in either sty1+ or wis1+ (Fig 5), indicating that the role of these ... (Fig 1) Pyp1p and Pyp2p phosphatases appear to play a key role in the dephosphorylation of the osmotic stress-activated Sty1p [20] Interestingly, however, the Sty1p...

Ngày tải lên: 08/03/2014, 09:20

... endocytosis of cloned rat somatostatin receptor subtypes expressed in insulinoma cells J Neuroendocrinol 9, 741–751 21 Lucius R & Mentlein R (1991) Degradation of the neuropeptide somatostatin ... [125I]Tyr1-octreotide in SSTR3-expressing rat insulinoma cells To examine the fate of SST-14 cointernalized with SSTR3, we measured the uptake of [125I]Tyr11-SST14 in R...

Ngày tải lên: 16/03/2014, 06:20

... TRAIL on the liver carcinoma cells QGY-7703 To investigate the apoptotic function of TRAIL containing the extracellular domain (amino acids 114–281) of the human liver cancer cell line, QGY-7703 ... in the hepatocellular carcinoma cells, QGY-7703, we treated these cells with eight different agents, at increasing concentrations, with and without TRAIL, then analysed...

Ngày tải lên: 23/03/2014, 17:22

Ngày tải lên: 02/05/2014, 06:20

... al., Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits Journal of Translational Medicine ... humans Further improvements of the recombinants, using the E6 and E7 transgenes deleted of the p53 and p105Rb cellular binding domai...

Ngày tải lên: 18/06/2014, 16:20

... and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant Proc Natl Acad Sci USA ... infection, demonstrating an important role of clathrin for RSV entry [9] Proteins that are internalized through the clathrin-mediated pathway usually bear the well characterized sorting signa...

Ngày tải lên: 20/06/2014, 01:20

... Kelfer - Chế phẩm : viên nang 0,25g 0,5 g - Liều lượng : 2 5- 75 mg/kg/ngày, uống chia 2- lần - Tác dụng phụ : gặp : buồn nôn, mệt mỏi, mồ hôi trộm, đau khớp đặc biệt dùng liều cao kéo dàI - Theo ... Urobilirubin niệu ( + ) - Điện di có Hb bất thường : b - thalassemia đồng hợp tử : HbF > 10% với trẻ > tuổi , tới 90% > 25% với trẻ từ tháng – tuổi b - thalas...

Ngày tải lên: 02/07/2014, 08:21

... tiết THỂ β Thalassemia/ HbE (thể dị hợp tử kép) - Lâm sàng: giống thể nặng - CLS: giống thể nặng điện di Hb thấy HbE tăng cao > 10% + Hb E, Hb F tăng cao + Hb A1 giảm nặng - Thalasemia bệnh di truyền, ... tăng, có HC non máu ngoại vi - Điện di Hb: thay đổi thành phần Hb điện di đặc hiệu cho chẩn đoán β- Thalassemia nặng: + Hb F tăng cao > 10-90% + Hb A2 tăng >3,5% + Hb A1 giảm nặng 3.2.2...

Ngày tải lên: 12/07/2014, 21:20