Nitroguanidines and guanidino containing hetereocycles as po

Nitroguanidines and guanidino containing hetereocycles as potential nitric oxide synthase inhibitors

... Chemistry of Nitric Oxide 1.2 Nitric Oxide and Nitric Oxide Synthase 1.3 Nitric Oxide Synthase Isoforms 1.4 NOS Structure and Function 10 1.4.1 NADPH and Oxygen 11 1.4.2 Calmodulin 12 1.4.3 FAD and FMN ... Whereas for the inducible mode, NO is generated in large fluxes and is associated with the destructive indirect biological effects of NO.[3, 20] 1.2 Nitric...

Ngày tải lên : 26/11/2015, 23:06

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Synthesis of guanidino analogues as potential nitric oxide synthase inhibitors

... SYNTHESIS OF GUANIDINO ANALOGUES AS POTENTIAL NITRIC OXIDE SYNTHASE INHIBITORS BONG YONG KOY 2004 SYNTHESIS OF GUANIDINO ANALOGUES AS POTENTIAL NITRIC OXIDE SYNTHASE INHIBITORS BONG ... Oxide Synthase (NOS) Isoforms of Nitric Oxide Synthase Physiological Roles of NO and Pathology of NO Overproduction Inhibition of Nitric Oxide Syn...

Ngày tải lên : 16/09/2015, 17:13

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Báo cáo y học: " Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice" pot

... main finding of the present study was a disjunction between leukocyte adhesion and vascular leakage; leukocyte rolling and adhesion was increased in septic mice both with and without iNOS induction, ... compared with wild-type controls (to 18.8 ± 6.9 rolling cells/minute; P = 0.048) and further increased in iNOS- Leukocyte rolling Shown is leukocyte rolling in wild-t...

Ngày tải lên : 13/08/2014, 10:20

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Báo cáo y học: "Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis" pot

... distinctly generated Synovial tissues released miRNAs similar to synovial fluid miRNAs To estimate the origin of plasma or synovial fluid miRNAs, FLSs, synovial tissues, PB MNCs, and synovial fluid ... the handiness of plasma and synovial fluid miRNAs as biomarkers Although we showed that synovial tissue is a main source of synovial fluid miRNA, the mec...

Ngày tải lên : 12/08/2014, 12:20

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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: electron transfer through the nitric oxide synthase ﬂavoprotein domain pdf

... the rate of electron import into the FMN subdomain and the resulting formation of FMNH2 The extent to which KeqA or the rate of FMNH2 formation influences electron flux through the NOS flavoprotein ... NOS, the second electron is provided to the hemedioxy species by a bound H4B cofactor rather than by the flavoprotein domain [16] The H4B radical is th...

Ngày tải lên : 18/02/2014, 11:20

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Báo cáo khoa học: Space, time and nitric oxide – neuronal nitric oxide synthase generates signal pulses pptx

... reactivity of nitric oxide J Exp Med 169, 101 1–1 020 Abu-Soud HM & Stuehr DJ (1993) Electron transfer in the nitric- oxide synthases Nitric oxide synthases reveal FEBS Journal 276 (2009) 667 7–6 688 ª ... purview and parameters Nat Rev Mol Cell Biol 6, 15 0–1 66 Lancaster J (1997) A tutorial on the diffusibility and reactivity of free nitric oxide Nitric Oxide 1,...

Ngày tải lên : 07/03/2014, 00:20

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Báo cáo khoa học: Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs potx

... isoforms of NOS with CaM-TnC chimeras demonstrated that the roles of the four EF hands in the binding and activation of the cNOS and iNOS enzymes are distinct [13] Replacement of any CaM EF hand ... enzymes during binding and activation [4,5] The present investigation, designed to further assess the role of the two CaM EF hand pairs in the binding and...

Ngày tải lên : 16/03/2014, 13:20

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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx

... related to the binding of l-Arg [10–14] and NOHA [10], nothing is known about the thermodynamics and kinetics of the binding of guanidines and N-hydroxyguanidines to iNOS Removal of the a-amino or ... from the conversion of the LS NOS–Fe(III)–ImH complex to the HS NOS–Fe(III)–l-Arg complex was observed Inhibition of the binding of l-Arg to i...

Ngày tải lên : 16/03/2014, 22:20

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Báo cáo khoa học: Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing the levels of octamer-binding factor-2 doc

... octamer and the factors binding to it in LPS-induced gene expression Although involvement of octamer-binding factor- 1 (Oct-1), another octamer-binding protein, cannot be excluded in the LPSinduced expression ... expression of iNOS and G-CSF protein and mRNA were evaluated in macrophages, and the involvement of Oct-2 in LPS ⁄ mTOR-induced iNOS and G-C...

Ngày tải lên : 22/03/2014, 17:20

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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot

... In vivo degradation of NOS and HSP90 by calpain M Averna et al Table Levels of native and 15 kDa calpastatin species in brain and aorta of NMS and HMS rats treated with HSD for weeks The data ... compilation ª 2008 FEBS M Averna et al In vivo degradation of NOS and HSP90 by calpain higher than in aorta, resulting in a much higher HSP90 to NOS ra...

Ngày tải lên : 30/03/2014, 04:20

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Báo cáo khoa học: Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395 docx

... tryptophan in the isolated FAD domain of rat nNOS (F1395W, F1395S and F1395A) and by probing the thermodynamic and kinetic consequences of these mutations We have studied the thermodynamic and kinetic ... determination of the midpoint reduction potentials of ﬂavin cofactors, and also of the haems in the case of NOS and P450 BM3 In spec...

Ngày tải lên : 30/03/2014, 14:20

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Báo cáo khoa học: "Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis" pdf

... the Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 13 appropriate biotinylated second antibody and the avidinbiotin peroxidase ... der Valk, P Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating mult...

Ngày tải lên : 07/08/2014, 14:22

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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx

... counterstained with hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in ... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis h...

Ngày tải lên : 07/08/2014, 14:23

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Báo cáo khoa học: "Increased expression of neuronal nitric oxide synthase in astrocytes and macrophages in the spinal cord of Lewis rats with autoimmune encephalomyelitis" pps

Ngày tải lên : 07/08/2014, 15:20

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Báo cáo y học: "Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes" pps

... and iNOS expression in bovine articular chondrocytes Nitric Oxide 2002, 6:35-44 66 LaPointe MC, Isenovic E: Interleukin-1β regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves ... [70] in A549 cells (human alveolar type II lung carcinoma cell line) stimulated by R922 a mixture of cytokines containing interferon-γ, TNF-α and IL-1β Inhibition...

Ngày tải lên : 09/08/2014, 06:23

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