Nitric oxide mediated transcriptional regulation

... nuclear export signal nuclear factor k B nerve growth factor nuclear localization signal nitric oxide nitric oxide synthase open reading frame poly acrylamide gel electrophoresis poly ADP-ribose ... of NO involve the transcriptional up -regulation of cytoprotective genes such as Cox-2, CuZn superoxide dismutase, heme-oxygenase-1, heat shock protein 70 and manganese superoxide dismu...

Ngày tải lên: 26/11/2015, 23:06

... tighter binding of cadmium than zinc in metallothioneins and the preference of zinc in the more flexible b-domain In addition to the already described differences in flexibility of the b-domain in MT ... reported increased metal release in the presence of oxidized glutathione (GSSG) and even slightly tighter metal binding under the in uence of reduced...

Ngày tải lên: 07/03/2014, 15:20

... that arginase attenuates iNANC nerve-mediated airway smooth muscle relaxation specifically by inhibition of NO generation, presumably by limiting L-arginine availability to nNOS [23] In a guinea ... mechanism that may be of particular importance in relation to reduced bioavailability of L-arginine in the airways is increased activity of arginase, which hydrolyzes Larginine in...

Ngày tải lên: 12/08/2014, 16:20

... show that E 2A is involved in fine control of pre-mature B-cell apoptosis mediated by BCR signaling, via transcriptional regulation of survivin, IAP2 and caspase-8 genes Results Insignificant in uence ... BCR signaling and E 2A depletion, mainly via moderate changes in amounts of the inhibitors survivin, IAP2 and ICAD (and probably...

Ngày tải lên: 16/03/2014, 04:20

... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... regulation is mediated by binding of the regulatory protein DmdR1 to the iron box located in the promoter region of the...

Ngày tải lên: 16/03/2014, 11:20

... et al.: Aciculatin inhibits lipopolysaccharidemediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways Journal of Biomedical ... proinflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which can be induced by LPS or cytokines, are found to...

Ngày tải lên: 10/08/2014, 05:21

... reference preparation The sensitivity of the assay was pg/tube To analyze the variability of the assay, series of plasma of 10 replicates at different concentrations of the prolactin standard ... the mean ± S.E.M To study the MTX and L-NAME effects on the parameters that characterize the episodic prolactin secretion and on dopamine concentration, the...

Ngày tải lên: 10/08/2014, 09:20

... as: Brodsky et al.: The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages ... kinetics I At h, AS101 probably enters the nucleus and may interfere with the DNA-binding ability of the NFB complex resulting in...

Ngày tải lên: 11/08/2014, 08:22

... synthase (NOS; EC 1.14.13.39), and the citrulline generated as a by-product can be recycled to arginine by successive actions of argininosuccinate synthetase (AS; EC 6.3.4.5) and argininosuccinate ... accidents and also during incidents involving anesthesia To understand the role of citrulline- NO cycle enzymes, GS and the oxidative status in anoxia and reperfusion...

Ngày tải lên: 26/10/2012, 09:07

... 1,193/100,000/year in those over 60 years of age Cancer followed with a frequency of 74.71/100,000/year The frequency in males (77.6/100,000/yr) exceeded only slightly the frequency in females ... 100,000 over years for the conditions specified in the hypothesis that a very high dietary intake of flavanoids might predict Note the remarkable year-to-year consistency in Panama and the very mu...

Ngày tải lên: 31/10/2012, 15:12

... the rate of electron import into the FMN subdomain and the resulting formation of FMNH2 The extent to which KeqA or the rate of FMNH2 formation influences electron flux through the NOS flavoprotein ... NOS, the second electron is provided to the hemedioxy species by a bound H4B cofactor rather than by the flavoprotein domain [16] The H4B radical is th...

Ngày tải lên: 18/02/2014, 11:20

... Mapping of transcription initiation sites in the human DNASE1 gene To identify the transcription initiation sites of DNASE1 in pancreas, 5¢-RACE based on RNA ligasemediated and oligo-capping ... including characterization of the promoter region of the gene and the associated transcriptional factors Therefore, delineation of the transcriptional Promot...

Ngày tải lên: 19/02/2014, 06:20

... localization of iNOS to apical domains of intestinal epithelial cells Particulate fraction association of iNOS in vivo In order to determine the distribution of iNOS in intestinal epithelial cells in vivo, ... epithelial cells Apical distribution of iNOS in intestinal epithelial cells To get more insight into the localization of iNOS in intes...

Ngày tải lên: 19/02/2014, 16:20

... analysis of T4(1 47 0)–GFP and T4(259 47 0)–YFP HeLa cells were seeded on glass bottom dishes and were transiently transfected with expression constructs encoding T4(1 47 0)–GFP and T4(259 47 0)–YFP ... of T4(1 47 0)– GFP and T4(259 47 0)–YFP but had only a minor effect on the respective cytoplasmic-located protein fraction (Fig 8) Correspondingly, fluorescence of cytoplasmic T4(...

Ngày tải lên: 21/02/2014, 15:20

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inh...

Ngày tải lên: 22/02/2014, 04:20