Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DELIVERY OF DIAGNOSTIC/ THERAPEUTIC AGENTS: THEIR POTENTIAL APPLICATION IN BRAIN CANCER THERAPY YU QIANRU (B.Eng, Southeast ... Limitations in Modern Chemotherapy 2.2 Brain Cancers and Blood Brain Barrier (BBB) 2.2.1 Brain cancers and cancer treatment 2.2.2 Introduction to the blood brain barrier 2.2.2.1 H...

Ngày tải lên: 26/11/2015, 22:41

... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood...

Ngày tải lên: 26/11/2015, 22:48

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CONTROLLED AND TARGETED DELIVERY OF PROTEIN DRUGS SMALL AND MOLECULE DRUGS BY LEE SIE HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carri...

Ngày tải lên: 26/11/2015, 22:41

... NANOMEDICINE: MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER TREATMENT LIU YUTAO (B.Sc., Fudan University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... development of cutting-edge nanoparticles of biodegradable polymers with overall fascinating performance demonstrates the progress in the field of nanomedicine for ca...

Ngày tải lên: 10/09/2015, 15:49

... MULTIFUNCTIONAL NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DIAGNOSIS AND TREATMENT OF CANCER PAN JIE (M ENG., TIANJIN UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... nanoparticles of biodegradable polymers for QDs formulation for targeted and sustained imaging for cancer diagnosis at its early stage Two polymers of...

Ngày tải lên: 14/09/2015, 08:45

... (PLGA/MMT) nanoparticles decorated by trastuzumab for targeted chemotherapy of breast cancer Biomaterials 2008; 29(4): 475-486 Sun B, Feng SS Trastuzumab decorated nanoparticles for targeted chemotherapy ... conjugation of trastuzumab on NP surface for targeted drug delivery Experiments were carried out to investigate the feasibility of the obtained NPs fo...

Ngày tải lên: 14/09/2015, 08:48

... PACLITAXEL LOADED NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER CHEMOTHERAPY KHIN YIN WIN (M Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL ... potential analysis of various formulations of paclitaxel- loaded PLGA nanoparticles 81 Figure 13 XRD analyses of paclitaxel, TPGS, blank PLGA nanoparticles and p...

Ngày tải lên: 15/09/2015, 17:08

... DNA: NANOPARTICLES < /b> OF < /b> BIODEGRADABLE < /b> POLYMERS < /b> FOR < /b> GENE < /b> THERAPY < /b> OF < /b> HEPATITIS < /b> B JUNPING WANG (B Eng., ZJU, China) A THESIS SUBMITTED FOR < /b> THE DEGREE OF < /b> MASTER OF < /b> SCIENCE GRADUATE PROGRAM IN BIOENGINEERING ... gastrointestinal (GI) barrier and blood brain barrier, thus can benefit oral gene < /b> delivery and b...

Ngày tải lên: 05/10/2015, 21:33

... Pellets of single phase sample were prepared using a stainless steel die measuring mm in diameter Sufficient amount of powder was added, cold pressed uniaxially, and sintered at 1100oC in order to increase ... its volatile, reactive characteristic and relatively low firing temperature in forming binary or ternary materials with other elements, e.g bismuth vanadates, bismu...

Ngày tải lên: 07/08/2014, 14:20

... forward 5 -CCGGTGACAAAGCAGGTAGAG-3’ and reverse 5 -GTGAACTTGCAGAGGTTCGTGTA-3’ pair of primers, whereas the use of the HPRT1 forward 5 TGGAAAGGGTGTTTATTCCTCAT-3’ and reverse 5 -ATGTAATCCAGCAGGTCAGCAA-3’ ... study, the analysis and the interpretation of the data, the statistical analysis and supervised the study All authors read and approved the final manuscript Page 1...

Ngày tải lên: 13/08/2014, 13:20

... saturation of the two isoenzymes of OGDH with 2-oxoglutarate Discussion Identification of novel OGDH isoform and its implication in brain metabolism Distinguishing proteins with highly similar ... analysis predicting it to be a novel OGDH isoenzyme [16], the protein has not been reported in mammalian mitochondrial proteomes [17–19] We show that the presence in brain of...

Ngày tải lên: 23/03/2014, 06:20

... participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... suppressor genes could be methylated in lung cell lines and tumors Next, we determined whether the methylation status of such genes could contribute for lung...

Ngày tải lên: 18/06/2014, 16:20

... perspective into the characteristics of time-varying spectrum via studying the properties of the corresponding kernel However, to maintain physical meaningness in time-varying spectrum and coherence, ... normalization of the time-varying cross spectrum The time-varying coherence certainly inherits the characteristics of the time-varying spectra Therefore, the multisca...

Ngày tải lên: 21/06/2014, 16:20

... composition points out that beside terpinen-4-ol, other components in the tea tree oil have also the added effect of antibacterium 3.3.Investigation of tea tree oil application in cosmetics Since tea ... also other components in the tea tree oil have the antibacterial effect - The accepted dose of all fractions of the tea tree oil in pra...

Ngày tải lên: 22/07/2014, 03:20

... (11.9%), in ascending colon of 14 patients (15.2%), in transverse colon of subjects (8.7%), in hepatic flexure of patients (8.7%), in splenic flexure of patients (7.6%), in descending colon of 10 ... resection and type of operation are important prognostic factors In a recent Table 2: Results of multivariate analysis of clinical and laboratory data...

Ngày tải lên: 09/08/2014, 07:21