Molecular genetic analyses in acquired epilepsies

... respective DNA-binding motifs, TFs are also grouped in superclasses of basic domains, zinc-coordinating DNAbinding domains, helix-turn-helix domains and beta-scaffold factors with minor groove contacts ... rSNP occurring in a potential binding site for a TF does neither influence the binding affinity nor alter the corresponding gene expression However, in some cases the SNP leads to an...

Ngày tải lên: 19/11/2015, 16:41

... FEBS 2004 Genetic defects in fatty acid oxidation (Eur J Biochem 271) 471 Table Transporter proteins and enzymes involved in the mitochondrial saturated fatty acid oxidation FATP, fatty acid transport ... reflected in the profile of acyl-carnitines in blood and in patient cells metabolizing long-chain fatty acids [27] Not surprisingly, the severe metabolic block...

Ngày tải lên: 23/03/2014, 12:20

... 2B and Additional file 3) An INDEL revealed by p1 _VvAGL11 affects a putative O2-like box, p2 _VvAGL11 marks a putative TATA-box near far the transcription start site and p3 _VvAGL11 marks a (GAGA)n ... 5-AAGCCAAGGAATCACCCATT-3; for the internal reference gene EF1 -a (GSVIVT00024496001-8.4x) the oligos are 5-AGGATGGACAAACCCGTGAG-3 and 5-AAGCCAGAGATGGGGACAAA-3, and the ampl...

Ngày tải lên: 11/08/2014, 11:21

... Both RPA and XPA preferentially bind damaged DNA, and because RPA and XPA directly interact in the absence of DNA, the RPA-XPA complex has been implicated as a key component in the earliest stage ... implicates the damaged DNA binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase...

Ngày tải lên: 31/10/2012, 14:59

... the design of cellular manufacturing systems using genetic algorithms 6.2 The Design of Cellular Manufacturing Systems The first step in the process of designing a cellular manufacturing system ... Algorithm for Finding the Optimum Process Routings for Parts The aim of a cellular manufacturing system design is minimizing the cost of the system It can be gained by divi...

Ngày tải lên: 17/12/2013, 06:15

... Htt-interacting protein HIP -1 and its molecular partner HIPPI in the regulation of apoptosis and transcription, the two processes that are altered in HD [7,8] HIP -1 – its interacting partners and ... Conclusions HIP -1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor...

Ngày tải lên: 23/03/2014, 07:20

... This page intentionally left blank CONSERVING PLANT GENETIC DIVERSITY IN PROTECTED AREAS Population Management of Crop Wild Relatives Edited by José María Iriondo ... given to conserving intraspecific genetic diversity in situ and in particular while designing protected areas Why should we care about the genetic aspect of biodiversity conservation?...

Ngày tải lên: 29/03/2014, 16:20

... material were separated by centrifugation, and analyzed by SDS ⁄ PAGE and protein staining with Coomassie Brilliant Blue The protein ladder was run on the same gel (lane 5) ATPase assays were carried ... there was hardly any overlap of the two proteins, and they more or less eluted according to their theoretical molecular masses (70 and 140 kDa; Fig 6B) Apparently, the two H...

Ngày tải lên: 30/03/2014, 03:20