Identification of genomic alterations in castration resistant prostate cancer using next generation sequencing

... binding domain, and the ligand binding domain (LBD) The “hinge domain” links the LBD to the DBD (42) (Figure 6) Figure 6: Schematic representation of AR on Chromosome X (43) Upon the binding of ... CTD-2310E8 RP11-188K5 Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen 33 Methods 6.1 Next generation sequencing (SOLiD4) DNA Extraction ... using the SOLiD4 sequencing platform Objective III: Identification of novel therapeutic targets for castration resistant prostate cancer by whole exome sequencing, and functional validation of...

báo cáo khoa học:" Pain in castration-resistant prostate cancer with bone metastases: a qualitative study" pptx

... guidelines for cancer pain management, pain is often under treated in cancer patients [13,14], which may in part be because of the difficulties in assessing pain in a valid and reliable manner ... pain, least pain in the last 24 hours and worst pain in the last 24 hours, using an 11-point numerical rating scale (NRS) ranging from (no pain) to 10 (pain as bad as you can imagine) Although these ... pain was the worst in the last 24 hours, how would I rate that pain as far as everything that I’ve experienced in my life, from no pain to pain as bad as you can imagine I would say that my pain...

Báo cáo y học: " Androgens as therapy for androgen receptorpositive castration-resistant prostate cancer" ppt

... Intermittent Androgen Deprivation therapy is a strategy to periodically perform and terminate the androgen ablation therapy, therefore patients in “off -androgen ablation therapy periods may decrease ... signaling can be a potential therapy for AR-positive advanced prostate cancer Figure Androgen and alternative therapy for advanced prostate cancer After androgen ablation therapy, androgen treatment will ... deprivation therapies by increasing intracrine androgen synthesis within the prostate [36,37] Androgen Ablation Therapy Androgen ablation therapy, using luteinizing hormonereleasing hormone agonists...

ANALYSIS OF INTEGRATION SITES OF TRANSGENIC SHEEP GENERATED BY LENTIVIRAL VECTORS USING NEXT-GENERATION SEQUENCING TECHNOLOGY

... i ANALYSIS OF INTEGRATION SITES OF TRANSGENIC SHEEP GENERATED BY LENTIVIRAL VECTORS USING NEXT-GENERATION SEQUENCING TECHNOLOGY A Thesis Submitted to the Faculty of Purdue University by Yu-Hsiang ... August 2013 Analysis of Integration Sites of Transgenic Sheep Generated by Lentiviral Vectors Using Next-Generation Sequencing Technology Major Professor: Anna Malkova The development of new methods ... products of transgenic sheep fetal tissues-animal 709-2 22 Figure 4.4 LAM-PCR products of transgenic sheep fetal tissues-animal 498-1 23 Figure 4.5 LAM-PCR products of transgenic sheep fetal...

Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot

... et al.: A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant ... with estramustine- based combinations and the activity of combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients ... or 13-cis retinoic acid, interferon- alpha2b with paclitaxel (Arm B) Figure Progression Free Survival in patients treated with mitoxantrone, estramustine and vinorelbine (Arm A) or 13-cis retinoic...

Báo cáo y học: "Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space" pps

... of other signaling pathways may play a role in the emergence of CRPC The interaction of endothelin-1 (ET-1) with the G-protein coupled endothelin-A (ETA) receptor has been implicated in carcinogenesis, ... efficacy findings of the trial (Table 1) prompted the Independent Data Monitoring Committee to recommend unblinding the trial at the time of the interim analysis and the crossover of patients from the ... Interestingly, however, in model systems they may be inhibited by antiandrogens targeted to the ligand-binding domain, such as MDV3100 (see below) [20] Hypothetically this may be a consequence of inhibiting...

báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot

... strong predictor of adverse outcome, but other single genomic alterations, such as loss of 11q or gain of 17q, were overridden by the presence of any kind of segmental alterations in multivariate ... comprised 47% of the tumors, whereas it accounted for 28% of the cases in the study of Caren et al [8] Similar to the latter findings [8], this subgroup constituted 21% of the cases in a preliminary ... supported by the finding of only 2% flat genomic profiles in another study in which a tumor content of 60% had been used for sample selection [6] Because of the rare occurrence of neuroblastomas...

Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary pot

... Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary http://www.nap.edu/catalog/12148.html Diffusion and Use of Genomic Innovations in Health and Medicine workshop ... Academy of Sciences All rights reserved Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary http://www.nap.edu/catalog/12148.html DIFFUSION AND USE OF GENOMIC INNOVATIONS ... Academy of Sciences All rights reserved Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary http://www.nap.edu/catalog/12148.html DIFFUSION AND USE OF GENOMIC INNOVATIONS...

Identification of antibacterial species in plasma treated liquids

... Ireland, UK 16 30 after plasma treatment After 15 exposure time in the plasma- treated liquids, number of surviving microorganisms was estimated For plasma treatment of liquids containing suspended microorganisms, ... 12 plasma treatment time [min] Fig 1: Inactivation kinetics of E coli as a result of plasma treatment of bacteria-containing sodium chloride (NaCl) solution ( ) as well as addition to E coli of ... min-1 For data analyzing the software Chromeleon (Dionex) was used Results and Discussion Direct plasma treatment of ml E coli suspension resulted in inactivation of this microorganism within...

báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt

... frequent and responsive symptom domains Flow diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains Sixteen symptom domains were included ... domain (frequently present and responsive to change) Infrequent or unresponsive symptom domains Fifteen of the 28 symptom domains did not fulfill the criteria These symptom domains are listed in ... ratings of symptoms that improve during therapy Visual analogue scale ratings of symptoms that improve during therapy A box plot of the VAS ratings of symptoms is presented that improve during...

Báo cáo hóa học: " First identification of primary nanoparticles in the aggregation of HMF" potx

... cross-linked furanic species The continued growth in size of the cross-linked furanic species eventually results in the precipitation of the molecular clusters out of the solution into the primary ... participated in the data analysis and drafting of the manuscript XDS contributed in the planning of the experimental program and in discussing of carbon sphere formation mechanism DKZ contributed in the ... mechanism of the carbonaceous spheres under hydrothermal conditions In this study, we identified for the first time the formation of primary nanoparticles, which serve as the building blocks for the...

báo cáo hóa học: " F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin)" pdf

... this article as: Cook et al.: 1 8F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin) ... and in clinical trials, to the extent that bone metastases are often regarded as a non-measurable disease [4] Criteria exist which use radiographic changes to measure response in bone metastases, ... formation marker Methods This imaging study was performed as a pilot substudy of an open-label phase trial of Alpharadin in patients with bone metastases and castration-resistant prostate cancer...

báo cáo hóa học:" First identification of primary nanoparticles in the aggregation of HMF" doc

... cross-linked furanic species The continued growth in size of the cross-linked furanic species eventually results in the precipitation of the molecular clusters out of the solution into the primary ... and in drafting of the manuscript YNL is the cosupervisor who participated in the data analysis and drafting of the manuscript XDS contributed in the planning of the experimental program and in ... al.: First identification of primary nanoparticles in the aggregation of HMF Nanoscale Research Letters 2012 7:38 Competing interests The authors declare that they have no competing interests...

Báo cáo khoa học: "Identification of Acanthocephala discovered in changran-pickles and myungran-pickles" docx

... Kim et al intermediate host of E gadi Chu [3] and Cho [2] reported upon the distribution of glycogen, mucopolysaccharides, lipid and nucleic acid in the epicuticle of Echinorhynchus gadi In this ... base of neck In the middle of the trunk, two elliptical testes were arranged linearly Posterior to the testes, six cement glands, pyriform in shape were arranged linearly, with ducts leading into ... middle-sized in the acanthocephala, and proboscis was cylindrical in shape and the hooks on the proboscis were arranged in 9-26 longitudinal rows, with 4-16 hooks per Table Measurement of female...

Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx

... diagnosis by detecting both infiltrating eosinophils and the presence of eosinophil degranulation when conventional eosin and hematoxylin staining of the tissue was not interpreted as being significant ... pharmacokinetics to monitor compliance and gastrointestinal absorption of ingested corticosteroids In summary, this case describes a patient who likely has a lymphocytic variant of hypereosinophilic ... chronic eosinophilic pneumonia and hypereosinophilic syndrome Anti-neutrophil antibodies were repeatedly negative and intestinal, sinus and bronchial mucosal tissues did not show evidence of vasculitis...

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