Identification of genomic alterations in castration resistant prostate cancer using next generation sequencing

... binding domain, and the ligand binding domain (LBD) The “hinge domain” links the LBD to the DBD (42) (Figure 6) Figure 6: Schematic representation of AR on Chromosome X (43) Upon the binding of ... CTD-2310E8 RP11-188K5 Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen   33     Methods 6.1 Next generation sequencing (SOLiD4) DNA Extra...

Ngày tải lên: 19/11/2015, 14:04

... guidelines for cancer pain management, pain is often under treated in cancer patients [13,14], which may in part be because of the difficulties in assessing pain in a valid and reliable manner ... pain, least pain in the last 24 hours and worst pain in the last 24 hours, using an 11-point numerical rating scale (NRS) ranging from (no pain) to 10 (pain as bad as...

Ngày tải lên: 12/08/2014, 00:20

... Intermittent Androgen Deprivation therapy is a strategy to periodically perform and terminate the androgen ablation therapy, therefore patients in “off -androgen ablation therapy periods may decrease ... signaling can be a potential therapy for AR-positive advanced prostate cancer Figure Androgen and alternative therapy for advanced prostate cancer After androgen abla...

Ngày tải lên: 10/08/2014, 10:20

... i ANALYSIS OF INTEGRATION SITES OF TRANSGENIC SHEEP GENERATED BY LENTIVIRAL VECTORS USING NEXT-GENERATION SEQUENCING TECHNOLOGY A Thesis Submitted to the Faculty of Purdue University by Yu-Hsiang ... August 2013 Analysis of Integration Sites of Transgenic Sheep Generated by Lentiviral Vectors Using Next-Generation Sequencing Techn...

Ngày tải lên: 24/08/2014, 13:51

... et al.: A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant ... with estramustine- based combinations and the activity of combined navelbine and mitoxantrone, supporting the testing of combina...

Ngày tải lên: 18/06/2014, 16:20

... of other signaling pathways may play a role in the emergence of CRPC The interaction of endothelin-1 (ET-1) with the G-protein coupled endothelin-A (ETA) receptor has been implicated in carcinogenesis, ... efficacy findings of the trial (Table 1) prompted the Independent Data Monitoring Committee to recommend unblinding the trial at the time of the interim analys...

Ngày tải lên: 10/08/2014, 21:23

... strong predictor of adverse outcome, but other single genomic alterations, such as loss of 11q or gain of 17q, were overridden by the presence of any kind of segmental alterations in multivariate ... comprised 47% of the tumors, whereas it accounted for 28% of the cases in the study of Caren et al [8] Similar to the latter findings [8], this subgroup constit...

Ngày tải lên: 11/08/2014, 12:20

... Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary http://www.nap.edu/catalog/12148.html Diffusion and Use of Genomic Innovations in Health and Medicine workshop ... Academy of Sciences All rights reserved Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary http:/...

Ngày tải lên: 14/03/2014, 23:20

... Ireland, UK 16 30 after plasma treatment After 15 exposure time in the plasma- treated liquids, number of surviving microorganisms was estimated For plasma treatment of liquids containing suspended microorganisms, ... 12 plasma treatment time [min] Fig 1: Inactivation kinetics of E coli as a result of plasma treatment of bacteria-containing sodium chloride (NaCl) sol...

Ngày tải lên: 18/05/2014, 20:35

... frequent and responsive symptom domains Flow diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains Sixteen symptom domains were included ... domain (frequently present and responsive to change) Infrequent or unresponsive symptom domains Fifteen of the 28 symptom domains did not fulfill...

Ngày tải lên: 18/06/2014, 19:20

... cross-linked furanic species The continued growth in size of the cross-linked furanic species eventually results in the precipitation of the molecular clusters out of the solution into the primary ... participated in the data analysis and drafting of the manuscript XDS contributed in the planning of the experimental program and in discussing of carb...

Ngày tải lên: 20/06/2014, 23:20

... this article as: Cook et al.: 1 8F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin) ... and in clinical trials, to the extent that bone metastases are often regarded as a non-measurable disease [4] Criteria exist whi...

Ngày tải lên: 21/06/2014, 02:20

... cross-linked furanic species The continued growth in size of the cross-linked furanic species eventually results in the precipitation of the molecular clusters out of the solution into the primary ... and in drafting of the manuscript YNL is the cosupervisor who participated in the data analysis and drafting of the manuscript XDS contributed in the...

Ngày tải lên: 21/06/2014, 17:20

... Kim et al intermediate host of E gadi Chu [3] and Cho [2] reported upon the distribution of glycogen, mucopolysaccharides, lipid and nucleic acid in the epicuticle of Echinorhynchus gadi In this ... base of neck In the middle of the trunk, two elliptical testes were arranged linearly Posterior to the testes, six cement glands, pyriform in shape were arranged linearly, wi...

Ngày tải lên: 07/08/2014, 15:20

... diagnosis by detecting both infiltrating eosinophils and the presence of eosinophil degranulation when conventional eosin and hematoxylin staining of the tissue was not interpreted as being significant ... pharmacokinetics to monitor compliance and gastrointestinal absorption of ingested corticosteroids In summary, this case describes a patient who likely has a lymphocytic varia...

Ngày tải lên: 08/08/2014, 21:20