behavioral mechanisms of immune alterations in depression
Báo cáo Y học: Environmentally coupled hydrogen tunneling Linking catalysis to dynamics potx
... perturbing the system, with the perturbant being temperature in ht-ADH, and site-specific mutagenesis in SLO As discussed below, a wide variation in AH/AD can, in fact, be explained as arising from alterations ... predictability into classical reaction mechanisms In reactions such as the H• transfer of SLO, TST and attendant tunneling-corrections are inappropriate, and full tunneling models must be invoked What insight ... equal extents and with gating being the principal determinant of the temperature dependence of the KIE Thus, this model can provide unique insight into both Table Secondary kinetic isotope effects...
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Báo cáo y học: "Polymorphisms in melatonin synthesis pathways: possible influences on depression" pdf
... photoperiodic responses [8] Indeed, in our previous data, there was some trend associating high melatonin release with depression [4] Similar findings of delayed melatonin offset in depression have been ... through TRKB With an interest in extending and replicating the recent associations of AANAT and ASMT polymorphisms with depression, we examined the influence of SNPs in these genes on depression, the ... effect of ASMT upon the metabolic conversion of serotonin to melatonin The activity of both AANAT and ASMT might influence the concentration of N-acetylserotonin, which influences expression of TRKB...
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Báo cáo y học: " Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka" potx
... administered to both twins 31.0% of male twins and 25.5% of female twins reported living in the same household as one another These twins will necessarily share aspects of their ‘standard of ... genetic inheritance (A) Familial influences are assessed by looking for similarity within pairs of twins Crosstwin logistic regression models, making use of zygosity information, were run to examine ... impacts on each twin in a pair (E, chiefly found by examining dissimilarities within MZ pairs), or familial influences that make twins similar to one another which includes shared upbringing (C) plus...
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Báo cáo y học: "Virus-derived transgenes expressing hairpin RNA give immunity to Tobacco mosaic virus and Cucumber mosaic virus" pdf
... mode of expression in terms of resistance Correlation between the number of transgene insertions and the type of RNA silencing in tobacco were investigated in this study Genomic DNA of each line ... SalI, and then inserted into the SalI site of pBIN -In- CMVΔRep to produce recombinant plant expression vector pBIN-CMVΔRep (i/r) (Figure 1), containing inverted repeats sequence of CMV ΔRep separated ... The progeny of T0 lines MP16 and Rep15 was confirmed to a have a segregation ratio of 3:1 (immune: susceptible), suggesting the presence of a single dominant transgene locus in each line, and Southern...
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Báo cáo y học: "Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells" pdf
... the RING finger:B box:Coiledcoil (RBCC) family proteins The RING finger motif features a cysteine-rich consensus, which contains two interleaved Zn++-binding sites [37] Many RING finger proteins ... belongs to the subclass of the B30.2 or RFP-like domains In butyrophilin, the B30.2 domain, which contains 170 residues, is involved in ligand binding [41] Of interest, TRIM proteins localize to particular ... oligomers [36] In addition, TRIM5α contains a SPRY domain at its C-terminus (Fig 4) The SPRY domain was originally identified in the splA kinase of Dictyostelium and the rabbit ryanodine receptor...
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Báo cáo y học: "Bench-to-bedside review: Rare and common viral infections in the intensive care unit – linking pathophysiology to clinical presentatio" ppt
... shock-inducing mechanisms thought to be due to the release of kinins and cytokines [106,107] The syndrome’s clinical presentation, rapid resolution, and histopathologic findings of interstitial infiltrates ... Masurel N, Marine WM: Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man Am J Epidemiol 1973, 97:44-49 Wilson IA, Cox NJ: Structural basis of immune recognition of influenza ... occurs via a number of mechanisms Upon receptor binding, a large cytokine response occurs, with interleukin (IL)-2, IL-6, and interferon gamma predominately Available online http://ccforum.com/content/12/4/219...
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A study of the mechanisms of immunity to pasteurella haemolytica infection
... against 1959 A) investigate in immunity from bacterins were subsequently gous strains suggested roles determining the of of of with resulting the specificity somatic antigens of only which of ... mortality, of the'organisms susceptibility inoculation with of TV infection provided hydrolysate to confined Brain Intracerebral mice casein of trauma the a suitable solution and brain individual induced ... recognition sheep of of type T sheep 19 in haemolytica P carrying late from to no and weather the flocks in the this nasal of periods known is survey pattern P of of to interesting types There of carriers...
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Linking the linguistic to the social
... is being a family, learning (or not learning) Latin, or playing music, by virtue of engaging over time in that endeavor, the participants in each of these groups develop ways of doing things ... move into acting as a profession in the nineteenth century were often seen as having deplorably loose sexual morals We also often find feminine suffixes bringing their own additional meanings For ... role in certain kinds of practice, and thus there will be some clustering of discussion of parts of the grammar To orient the nonlinguist reader, this chapter offers a quick preliminary tour of...
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Tài liệu From Great Depression to Great Credit Crisis: Similarities, Differences and Lessons pdf
... others less In this paper we fill in the global picture of the two downturns We show that the decline in manufacturing globally in the twelve months following the global peak in industrial production, ... movements in global industrial output during the two crises.12 Since we are interested in the extent to which world industrial output declined during the two periods, we plot the two indices from ... production in the current crisis, including the growth in vertical specialization (Yi 2008, Freund 2009, Tanaka 2009) and the difficulty of obtaining trade finance during the credit crunch (Auboin 2009a,b)...
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Tài liệu Indigenous Knowledge Local Pathways to Global Development doc
... contribution of women to maintaining agro-biodiversity Droughts periodically affect many regions in Africa, often causing widespread famine In their role as principal providers of food in the event of ... engaged in casual sex Uganda also pioneered approaches in reducing stigma, bringing discussion of sexual behavior out into the open, involving HIV-infected people in public education, persuading individuals ... involve people in discovering and preserving existing canons of knowledge—it enables them to “make” new knowledge And in fact the majority of case studies linking IK to education in the set included...
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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx
... of authentic War1p in diploid cells (Fig 2), which might be a direct consequence of impaired dimer formation of War1p or a lack of DNA binding Indeed, in the case of War1-42p, in vivo footprinting ... data indicate the involvement of Pdr12p in the export of by-products of amino-acid catabolism, as a pdr12D strain displays hypersensitivity to fusel acids derived from leucine, isoleucine, valine, ... of rabbit polyclonal antibodies and immunoblotting Polyclonal antibodies to War1p were raised in rabbits against a GST-War1p fusion protein containing 294 amino acids of the C-terminal part of...
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Tài liệu Báo cáo khoa học: Photochemical cross-linking of Escherichia coli Fpg protein to DNA duplexes containing pdf
... and silver staining Equal mobilities of the radioactive and the protein-containing bands indicated covalent attachment of DNA to the enzyme The yield of the photochemical cross-linking reaction ... and binding of DNA duplexes by the Fpg protein Specificity of Fpg protein binding The interaction between the Fpg protein and modified DNA duplexes I and II was shown to be specific by two independent ... sequences but containing no oxoG, did not Binding of the modified DNA duplexes to the Fpg protein DNA duplexes I–III were tested for binding to the Fpg protein in order to determine whether it can...
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Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc
... 247 ⁄ 248 in UVB-induced skin tumours of wild-type mice [41], indicating that Hupki mice can reproduce TP53 hotspot alterations typically found in sunlight-exposed human skin of healthy individuals ... variants of the Hupki mouse A common polymorphism occurs at codon 72 in TP53, resulting in either a proline (Pro72) or an arginine (Arg72) This occurs in the region of the gene encoding the polyproline ... sites are inherently promutagenic for two main reasons First, spontaneous deamination of 5-methylcytosine creates thymine and is considered to be a main source of C fi T transitions in internal...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... effects of loss of Mfl on the size and patterning of the wing The results reported here indicate that mfl silencing affects organ dimensions mainly by reducing cell size and increasing apoptosis Intriguingly, ... marked increase in cell density occurring in wings of the 46282 ⁄ nub–GAL4 genotype but not in those of the 46282 ⁄ en–GAL4 genotype This indicates that final wing size is regulated by reducing cell ... phenotypes obtained in the 46282 strain were similarly observed in both the 34597 and 34598 lines Loss of Mfl pseudouridine synthase affects both size and morphogenesis of the developing wing To overcome...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... is involved in multiple signaling pathways a wide range of substrates, and it has been suggested to be the integrative point of multiple pathways [3] The MAPK cascade consists of three interlinked ... protein kinase and woundinduced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10] Their orthologs in other plant species, including MPK3 ... Virus infection-induced H2O2 accumulation detected by DAB staining (B) Abiotic stress-induced H2O2 and OÀ accumulation detected by DAB staining and NBT staining, respectively WT, wild-type role of...
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Báo cáo Y học: Evaluation of two biosynthetic pathways to d-aminolevulinic acid in Euglena gracilis potx
... Biosynthesis of d-aminolevulinic acid in higher plants Plant Physiol 53, 291±296 10 Beale, S.I & Castelfranco, P.A (1974) Biosynthesis of d-aminolevulinic acid in higher plants II Formation of d-aminolevulinic ... C]serine is transformed to glycine (4) in the presence of tetrahydrofolic acid, and N5,N10-[13C]methylenetetrahydrofolic acid is derived from the 13C-carbon of L-[3-13C]serine and tetrahydrofolic ... the synthesis of a porphyrin J Biol Chem 159, 567±568 Shemin, D & Rittenberg, D (1946) The biological utilization of glycine for the synthesis of the protoporphyrin of hemoglobin J Biol Chem...
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Báo cáo khoa học: " Linking Events and Relations to Timestamps" pptx
... temporal linking The remainder of this paper goes into the details of our approach for temporal linking, and presents empirical evidence for the effectiveness of our approach The contributions of this ... baselines for comparison, parameter settings, and the results of the experiments 5.1 Benchmark We evaluated our approach in different tasks: Linking Timestamps and Events in the IC domain Linking ... evaluation In Proceedings of the LREC Conference, Canary Islands, Spain, July Oren Etzioni, Michele Banko, and Michael Cafarella 2007 Machine reading In Proceedings of the AAAI Spring Symposium...
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Báo cáo khoa học: An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector pot
... design a single molecule containing the cDNA of human COX-1 and PGIS with a connecting TM linker derived from human bovine rhodopsin [15] (Fig 1) Cloning of Trip-cat enzyme-1 by linking COX-1 ... an increase in thrombosis tendency [6] Also, the suppression of PGI2 biosynthesis by cyclo-oxygenase isoform-2 (COX-2) inhibitors was linked to increased rates of heart disease in human clinical ... activity in inhibiting non-AA-induced aggregation Prostacyclin-synthesizing protein with COX-1 and PGIS properties (Fig 7B), such as that of collagen This indicates that HEK293 cells stably expressing...
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Báo cáo khoa học: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells pdf
... determined the variation of amount of glycoprotein in cells As shown in Fig 5E, although the total amount of protein in cells decreased to 87% after 48 h of incubation, the amount of glycoprotein ... This distinction may be due to differences in the mechanism of action of swainsonine and bafilomycin A1 Swainsonine inhibits both lysosomal and nonlysosomal mannosidases, whereas bafilomycin A1 blocks ... then mixed with 200 lL of lipofectamine solution, dissolving lL of Lipofectamine 2000 in Opti-MEM, and transfected into subconfluent 293A cells in mL of Opti-MEM in six-well plates The 293A cells...
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Báo cáo khoa học: Irreversible cross-linking of heme to the distal tryptophan of stromal ascorbate peroxidase in response to rapid inactivation by H2O2 ppt
... apoprotein of the catalytic site ˚ (Fig 4B) Because the indole ring of Trp35 is 3.18 A from the porphyrin ring in tsAPX (the distance between nitrogen of the indole ring and C6 of the porphyrin ring) ... heme-binding amino-acid residue in H2O2-inactivated stromal APX To determine which amino-acid residue in the apoprotein was cross-linked to heme, the inactivated tsAPX was digested with trypsin ... kinetic parameters of APXs To investigate the role of Trp35 in the cross-link and the inactivation of APX by H2O2, we created a mutant form of tsAPX in which Trp35 was changed to phenylalanine...
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