Structural determinants in the folding of epidermal growth factor (EGF) like domains

... there could be a link between EGF-induced reduction in Bid and tBid levels and the ubiquitin ligase activity of Itch In this study, we first examined the ability of Itch to interact with Bid and ... proteins Bim and Bak and the C-terminal fragment of Bid The ubiquitin ligases responsible for the ubiquitylation are in most cases not known [44] Her...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 16/03/2014, 09:20

... have been identified in those strains that are responsible for most of the steps in the biosynthesis of the oligosaccharide portions of the LPS molecules The inner core of H in uenzae LPS has been ... common structural feature on surface structures of pathogens residing in the human respiratory tract, including H in uenzae Expression of PCho has been associat...

Ngày tải lên: 16/03/2014, 16:20

... GEM To gain insight into the mechanisms involved in EGFr modulation by gangliosides (particularly GD3), we investigated the distribution of human EGFr in the plasma membrane of CHO-K1 cells that ... or intracellular domains of the receptor GD3 was mainly detected in the plasma membrane, showing a distribution in patches, while EGFr was observed both in plasma membra...

Ngày tải lên: 16/03/2014, 16:20

... suggested that they may insert spontaneously into the thylakoid membrane The initial stages of this spontaneous insertion mechanism involve binding of the intermediate-size protein to the membrane, ... residues in the signal peptide The effects of the truncations were tested by assaying for the insertion of in vitro synthesized proteins into isolated thyla...

Ngày tải lên: 18/03/2014, 01:20

Ngày tải lên: 23/03/2014, 10:21

... 622 of human tenascin- C (Swiss-Prot: TENA _HUMAN) , EGF-14 (Fig 1), was synthesized by solid-phase Fmoc based strategy The synthesis was automatically performed Fig Amino acid sequence of human tenascin ... apparatus using a PrePak Cartridge 25 · 100 mm (Agilent) casted on a PrepLC Universal Base apparatus (Waters) and a Zorbax 300SB-C18 9.4 · 250 mm (Agilent) Samples were...

Ngày tải lên: 23/03/2014, 13:20

... RESEARCH ON ROLES OF THE GOVERNMENT IN ECONOMIC GROWTH AND ECOLOGICAL ENVIRONMENT PROTECTION 1.2.1 Research on roles of the government in economic growth Roles of the government in economic growth ... the first objective of the development 2.2 ROLES OF THE GOVERNMENT IN THE INCORPORATION OF ECONOMIC GROWTH WITH ECOLOGI...

Ngày tải lên: 14/07/2014, 13:34

... 21-01 rof deniatniam eb ot sah rotpecer sti dna FGEhr neewteb noitcaretni eht taht detroper saw tI noisicni eht fo yad eht no gninnigeb syad 41 rof h 21 yreve slamina eht ot yllacipot deretsinimda ... eussit racs evissecxe fo noitamrof eht gnisaerced ni elor a syalp ti saerehw ,ssecorp riaper dnuow eht secnahne FGE deilppa yllacipot ,elpmaxe roF ]91[ noitamrof racs no ecneulfni yna gnivah ......

Ngày tải lên: 07/08/2014, 18:21

... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... epiphyseal dysplasias (MEDs), and the metaphyseal chondrodysplasias They are usually inherited as fully penetrant autosomal dominant disorders The expression of the O...

Ngày tải lên: 09/08/2014, 06:22

... Immunohistochemical staining intensity scores A) Meningiomas stained with anti-EGFR antisera showing negative staining B) 1+ staining C) 2+ staining D) 3+ staining Original magnification for ... Beguinot L, Macchia V: Epidermal growth factor receptor in human brain tumors J Endocrinol Invest 1992, 15(1):31-37 Johnson MD, Horiba M, Winnier AR, Artiaga CL: The epidermal growth...

Ngày tải lên: 09/08/2014, 09:20

... Coulter Inc., Fullerton, CA, USA) according to manufacturer instructions Multiplex PCR and primer extension analysis of mutations in EGFR-216 promoter region and exons 18, 19, 20, and 21 Multiplex PCR ... amount of work and time required With this method, -216 promoter region and exons 18-21 of the EGFR gene were amplified with multiplex PCR in a sing...

Ngày tải lên: 10/08/2014, 05:21

... al.: Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients ... Effective inhibition of the epidermal growth factor /epidermal growth factor receptor binding by anti -epidermal growth facto...

Ngày tải lên: 11/08/2014, 08:21

... expression of the MUC5AC mucin (a predominant airway mucin) gene Interaction of EGFR with its ligands led to EGFR tyrosine kinase phosphorylation, and a selective EGFR tyrosine kinase inhibitor ... virus-induced goblet-cell metaplasia in pathogen-free rats, developing mucin- containing cells did not incorporate [3H]thymidine, suggesting that cell mitosis was not involved in synthe...

Ngày tải lên: 12/08/2014, 18:20

... Verifying the structural determinant of the canonical EGF -like domain fold 109! 4.2.2 The role of the structural determinant in the transition state of protein folding 109! 4.2.3 Extending the ... single protein scaffold Here, the study of the folding code of the canonical fold of the EGF -like domain serve as a good starting point to provide more...

Ngày tải lên: 13/10/2015, 16:41