THE ROLE OF INTERFERON REGULATORY FACTORS IN REGULATING THE EXPRESSION OF NKG2D LIGANDS

... IRF -3 responsive, including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms ... ArgII expression was inhibited by MG- 132 [20], suggesting indirectly an involvement of NF-jB in ArgII regulation Our study is thus the first direct demonstration...

Ngày tải lên: 07/03/2014, 21:20

... m wt )11 9/ +17 8 )11 9/ +14 3 )22/ +17 8 )22/+4 10 0 73 91 23 21 ± 10 ± 3.4 ± 2.6 10 0 13 3 10 0 15 0 ± ± ± ± 12 10 10 m ± ± ± ± 30 20 20 70 70 28 ± ± ± ± 20 not examined which sequences in the )11 8/)35 ... site(s) (A) Effect of point mutations in Ets and Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in the )11 9/ +17 8 reg...

Ngày tải lên: 16/03/2014, 18:20

... Role of HNFs in transthyretin gene expression Z Wang and P A Burke Fig Mutation of the HNF binding site mainly disrupts the corresponding HNF binding ability, and not that of other HNFs Nuclear extracts ... treatment with cytokines HepG2 cells were treated with or without cytokines for 18 h The interaction of HNF protein with the DNA binding site was determined by ChIP assay...

Ngày tải lên: 23/03/2014, 03:20

... activity of a transcription factor depends on the promoter context, which refers both to the specific arrangement of the cis-acting elements in the promoter and to the nature of the factors they bind ... ATF-2 and c-Jun can bind to p300 and CBP through multiple domains, with a preference of c-Jun for the N- and C-terminal regions and of ATF-2 for...

Ngày tải lên: 23/03/2014, 13:20

... regulated by Yap4 , shows a further decrease in gene expression in the double yap4 yap6 mutant strain, suggesting cooperation between these two transcription factors in mediating the stress response ... unpublished data) Nuclear localization of the fusion protein correlates not only with activation of FRM2 transcription, but also with growth in increasing concentr...

Ngày tải lên: 30/03/2014, 16:20

... this article as: Furr et al.: A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type by glial cells Journal of Neuroinflammation 2 011 ... III-transcribed RNA intermediate Nat Immunol 2009, 10 :10 65 -10 72 55 Melchjorsen J, Rintahaka J, S by S, Horan KA, Poltajainen A, Østergaard L, Paludan...

Ngày tải lên: 19/06/2014, 22:20

... that indicate that the PI3K pathway plays a predominantly anti-inflammatory role in microglial activation It played a particularly potent role in the induction of anti-inflammatory and immunoregulatory ... enhanced by PI3K/Akt presumably by post-transcriptional modification, since mRNA levels did not change Role of PI3K/Akt in astrocyte cytokine production In o...

Ngày tải lên: 19/06/2014, 22:20

... into antigen-induced arthritis (AIA) mice at day After 24 hours radioactivity in isolated organs and the rest of the body was determined using a γ-counter Thereafter, the total radioactivity recovered ... cells after arthritis induction is not effective On the one hand, transfer of Treg cells 24 hours after intra-articular antigen challenge might be too late to inhib...

Ngày tải lên: 09/08/2014, 06:22

... into the lungs and to increased pulmonary proinflammatory cytokine expression [7] However, the initial events induced by hyperoxia, thereby leading to acute inflammatory lung injury, remain incompletely ... [26–37] In a murine hyperoxia model, the effects of lisofylline on the activation of NF-κB and CREB, on the expression of proinflammatory cytokines in the lungs...

Ngày tải lên: 12/08/2014, 19:21

... required for the expression of many cytokines involved in the pathogenesis of acute lung injury [26–35] In acute lung injury caused by infection of bacteria, cytokine receptors HIF-1 consists of two ... function play a central role in initiating the innate immune system and in activating NF-κB Anti-inflammatory cytokines have the ability to suppress inflammat...

Ngày tải lên: 12/08/2014, 19:21

... neutrophils Infect Immun 2000, 68:4792-4794 doi: 10.1186/cc9025 Cite this article as: Mankhambo et al., The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian ... fundamental role in the maintenance of vessel integrity Angiopoietin-1 (Ang-1) and Ang-2 are ligands of the endothelial receptor tyrosine kin...

Ngày tải lên: 13/08/2014, 20:22

... complex [9-11] Histone tails can be modified in various ways, including acetylation, methylation, phosphorylation, and ubiquitination Even the regulatory role of histone acetylation, the best characterized ... and H4 acetylations have different regulatory roles [17-20] We investigated the validity of a cumulative model for the regulatory effect of histone acet...

Ngày tải lên: 14/08/2014, 17:22

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... of publications • Tham M, Ramasamy S, Gan H, Ramachandran A, Poonepalli A, Yu YH, Ahmed S Chondroitin sulfate proteoglycan stimulates neural stem cell survival via EGFR signalling pathways Manuscript ... quiescent and only become activated at the start of each hair cycle In addition, they are activated during tissue damage and participate in wound healing (Blanpain...

Ngày tải lên: 12/09/2015, 21:26

... damage signaling inducing the expression of NKG2D ligands, the underlying pathway that links the DDR to the upregulation of NKG2D ligands is not clear The importance of the NKG2D ligands in tumour ... replicationinhibiting agents induce the expression of the mouse NKG2D ligands of the Raet1 family and the induction of Raet1 is inhibited whe...

Ngày tải lên: 13/10/2015, 15:54