Gene expression changes in the brainstem in a mouse model of orofacial pain

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL OF OROFACIAL PAIN DR LUTFUN NAHAR NATIONAL UNIVERSITY OF SINGAPORE 2009 II GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL ... neuron in the sensory ganglion of cranial nerves VII, IX and X OROFACIAL PAIN The diagnosis and treatment of facial pain remains a gre...

Ngày tải lên: 07/10/2015, 09:55

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...

Ngày tải lên: 14/09/2015, 08:42

... infection and neoplasms Neuralgic pain is generally expressed in the facial area as idiopathic trigeminal neuralgia The ill-defined category of atypical oral and facial pain includes a variety of pain ... hyperalgesia, and in the area of normal tissue surrounding the injury site, as secondary hyperalgesia (c) Phase (Neuropathic Pain) These are abnormal pain states...

Ngày tải lên: 05/10/2015, 13:53

... effects, after intraperitoneal injection of KA in rats (Wilson et al 2005) and increased expression of genes related to neurodegeneration and astrogliosis after intraperitoneal KA-nicotine injection ... Model of Neurodegeneration _ CHAPTER GENE EXPRESSION ANALYSIS OF HIPPOCAMPUS IN KAINATE RAT MODEL OF NEURODEGENERATION 23 Chapter Gene Expression of Hipp...

Ngày tải lên: 07/10/2015, 09:55

... microarray analysis Additional data file is a table listing highly ranked retinal miR target genes predicted using miRanda The miRNA array data are available at Array Express [58] using accession ... version of this paper Additional data file is a table listing retinal miR expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expr...

Ngày tải lên: 14/08/2014, 08:20

... has been identified as a key proinflammatory mediator in experimental acute pancreatitis (AP) SP is a product of the preprotachykinin -A (PPTA) gene, and it binds mainly to neurokinin- 1 receptor ... either an aromatic or an aliphatic amino acid (Severini et al., 2002) Tachykinins are produced by three genes in mammals, namely preprotachykinin A (PPTA), preprotachykini...

Ngày tải lên: 09/09/2015, 17:54

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... (5’-GGCGUGUCUCUCU UACGAC-3”) SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1 ), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2 ), 5’-GAGCCGGAAAGUUAUUGUG-3’ ... tissues was significantly lower in the CCI group during the course of 255 TLR4 -siRNA treatment, indicating that intrathecal administration of TLR4 -siRNA significantl...

Ngày tải lên: 25/10/2012, 11:48

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...

Ngày tải lên: 12/08/2014, 14:20

... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray pl...

Ngày tải lên: 14/08/2014, 20:22