Effects of proteasome inhibition on neuronal cells

... 1.3.2 UPS dysfunction in AD 20 1.4 Induction of apoptosis by proteasome inhibition 23 1.5 Induction of heat shock response by proteasome inhibition 25 1.6 Aims of this study 26 ii Contents Page Chapter ... Generation of pIRES2-EGFP-HSP22 clone 80 4.4 Effects of transient transfection of pIRES2-EGFP-HSP22 on 82 murine primary cortical neurons 4.5 Effects of transien...

Ngày tải lên: 05/10/2015, 13:53

... (Fig.1C.) Effects of OPN siRNA constructs on migration and induction of apoptosis with or without irradiation We determined the effects of OPN siRNA and irradiation on the migration rate of MDA-MB-231 ... al.: Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells Radiation Oncology 2010 5:82 Submit your next manuscript to Bi...

Ngày tải lên: 09/08/2014, 09:20

... models of neuronal cell death [40-42] The present study aims to evaluate the effects of ginsenosides Rh1 and Rg2 on neuroprotection, cell differentiation and on ERK activation in neuronal cells ... percentage of PC12 cells possessing neurites was more than that of control (Figure 3b) 6-OHDA and ginsenosides cytotoxicity Cytotoxicity of 6-OHDA and ginsenosi...

Ngày tải lên: 13/08/2014, 14:20

... the expression of ecdysone receptor B1 isoform in imaginal wing cells of P interpunctella at the last larval instar In the fifth larval instar of M sexta, it has been reported in vitro that 20E induced ... 20E-induced differentiation of imaginal wing cells We first tested the sensitivity of IAL-PID2 cells to JH II examining the effects of this hormone on...

Ngày tải lên: 23/03/2014, 13:20

... psoriasis [15,17] To investigate the immunomodulatory effects of Panax ginseng, genechip analysis was used to examine the gene expression profile of TNF-α-treated human monocytic U937 cells with or ... results may contribute to the understanding of the molecular mechanisms of the immunomodulatory effect of ginseng and ginsenosides on TNF-α-mediated...

Ngày tải lên: 18/06/2014, 15:20

... plasma membrane integrity It Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells 25 Fig Flowcytometric detection of apoptosis of A549 cells treated ... rate of 10-14% in the USA [11] Therefore, it is clear that Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A...

Ngày tải lên: 07/08/2014, 23:22

... article as: Zhang et al.: Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:98 ... treatment Conclusions In conclusion, our study demonstrates that DNMT1 silencing could suppress proliferation and induce apoptosis of Hela and Siha cells...

Ngày tải lên: 10/08/2014, 10:21

... inhibitory effects of both PPARg ligands (Figure 3C, D, E) Thiazolidinediones inhibit TGF-b1-induced changes in N-cadherin expression independent of PPARg Low basal expression of N-cadherin in ... of inhibition of Smad signaling which could contribute to PPARg- dependent regulation of TGF-b1 responses in A549 cells In addition, PPARg- independent effects of...

Ngày tải lên: 12/08/2014, 11:20

... effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells Respir Res 2006, ... evidence of apoptosis in primary human small airway epithelial cells (SAEC) Primary human small airway epithelial ce...

Ngày tải lên: 12/08/2014, 15:21

... cells Cigarette smoke extract differentially caused cytotoxicity in a variety of alveolar epithelial cells and in primary human small airway epithelial cells A Various alveolar epithelial cells ... epithelial cell lines as well as in primary human small airway epithelial cells However, CSE triggered NF-κB activation and pro-inflammator...

Ngày tải lên: 12/08/2014, 16:20

... study was designed to examine whether cigarette smoke induces dysfunction of airway mast cells and epithelial cells via the donation of cigarette- derived NO It was hypothesized that the NO from cigarette ... prostaglandins and a variety of cytokines [7] In the lungs and skin of smokers mast cells increase in absolute numbers and smoking may be associate...

Ngày tải lên: 12/08/2014, 18:22

... maintained at above 4.0 mg/L throughout the experiment pH of the reactor was maintained at 7.5 + 0.3 with manual addition of acid (HCl) and base (NaHCO3) Approximately 15 ml of biofilm particles ... heterotrophs as shown in Table Their values would be based on data obtained from the batch tests Table Kinetic coefficients obtained with AQUASIM Autotrophs Maximum specific Mass Fractio...

Ngày tải lên: 05/09/2013, 08:40

... (See table 2.) The Effects of Childhood Stress on Health Across the Lifespan  The Effects of Childhood Stress on Health Across the Lifespan Table 1: Prevalence of Individual Adverse Childhood Experiences3 ... The Effects of Childhood Stress on Health Across the Lifespan is a publication of the National Center for Injury Prev...

Ngày tải lên: 12/02/2014, 19:20

... Age on Spare Part Costs: A Study of M1 Tanks of age on maintenance costs Then we examine what the available data show about M1 age and spare part costs, and we also analyze whether part turn-in ... average age and the exchange price valuation of total spare part demands Figures 4.1 (M 1A1 ) and 4.2 (M 1A2 ) visually confirm that there is not...

Ngày tải lên: 17/02/2014, 22:20