EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
... objectives of the study are to: Validate breast cancer cells as a model to study the dual inhibition of mTOR and telomerase Investigate rapamycin s inhibition of the mTOR pathway and telomerase in breast ... test the efficacy of mTOR kinase domain inhibitors in preclinical and clinical studies (Menon and Manning 2008) These will be discussed in det...
ANTI CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS INVOLVEMENT OF NON HOMOLOGOUS END JOINING AND TELOMERE TELOMERASE HOMEOSTASIS
... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...
Investigating the molecular mechanism of ERp29 regulated cell cycle arrest in breast cancer
... nodes behind the breastbone Or Inflammatory breast cancer is a rare type of breast cancer The breast looks red and swollen because cancer cells block the lymph vessels in the skin of the breast ... dissertation, the author attempt to investigate how ERp29 may regulate another effector of PERK, Nrf2 in breast cancer cell lines The levels of eIFα...
Báo cáo khoa học: "Reduction of radiation pneumonitis by V20-constraints in breast cancer" pps
... reaction to radiation following mantle-field irradiation Comparison of follow-up by conventional x-ray and by computed tomography] Radiologe 1988, 28:20-28 Page of 17 Lind P: Clinical relevance of pulmonary ... Pater J: Interpreting the significance of changes in health-related quality -of- life scores J Clin Oncol 1998, 16:139-144 23 Velikova G, Stark D, Selby P: Quality of...
Genomic analysis of chemo resistance to HDAC inhibitor in gastric cancer cells
... of gastric cancer cells to HDAC inhibitors……………… ……113 6.2 The heterogeneous response of gastric cancer cell lines to HDAC inhibitors……………………………………………………………………………………… …………114 6.3 HDAC inhibitors ... treatment of cancer, HDAC inhibitors will be applied into more and more clinical trial of different type of cancers Thus it is necessary to understand the resis...
Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
... 44 2. 1 2. 1.1 2. 1 .2 2.1.3 2. 1.4 Materials Ligand and inhibitors Antibodies Cell-lines Fresh frozen clinical specimens 44 44 44 45 45 2. 2 2. 2.1 2. 2 .2 2 .2. 3 2. 2.4 2. 2.5 2. 2.6 2. 2.7 2. 2.8 2. 2.9 2. 2.10 ... REGULATION OF PP2A BY HER- 2/ neu 77 4.1 77 Overview 4 .2 4 .2. 1 4 .2. 2 4 .2. 3 4 .2. 4 Results 80 Inhibition of HER- 2/ neu signalling using AG...
In vivo and in vitro study on potential combination therapy of COL 3 and tamoxifen in breast cancer a pilot study
... that acute doxorubicin administration decreased COL- 3 oral bioavailability and prolonged COL- 3 elimination in rats[1 23] In the present study, a potential combination therapy of COL- 3 and tamoxifen ... combination of tamoxifen and COL- 3 is rational, based on the marked antitumor activity of both agents against a variety of solid tumors, suc...
Investigating functions of ERp29 in mesenchymal to epithelial transition (MET) and epithelial plasticity in breast cancer cells
... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... proteins, including CDC42, Par6 and aPKC, did not seem to be involved in the ERp29- induced epithelial morphogenesis These findings demonstrated a novel function and...
Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...
Báo cáo sinh học: "Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" docx
... al.: Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer Journal of Translational Medicine 2011 9:133 Submit your ... factor; mTOR: Mammalian target of Rapamycin; PI3K: phospahtidylinositol-3 kinase; RCC: renal cell carcinoma; RTK: receptor tyrosine kinase; and T...
báo cáo hóa học:" Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" pot
... Elfiky et al.: Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer Journal of Translational Medicine 2011 9:133 ... factor; mTOR: Mammalian target of Rapamycin; PI3K: phospahtidylinositol-3 kinase; RCC: renal cell carcinoma; RTK: receptor tyrosine kinase; and T...
The relative effects of merit pay, bonuses, and long term incenti on future job performance
... merit pay, bonuses, and long- term incentives THE RELATIVE EFFECTS OF MERIT PAY, BONUSES, AND LONG- TERM INCENTIVES ON FUTURE JOB PERFORMANCE The logic behind pay-for -performance compensation is that ... Because of the restrictions on long- term incentives, Hypothesis predicted that the effect of bonuses would be stronger than the effec...
THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
... THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION ABSTRACT This paper examina the efficiency and price effects of mergers by applying a frontier profit ... potential or capacity t o improve Another potential explanation of the increase in measured profit efficiency from megamergers may be the speci...
The effects of early social-emotional and relationship experience on the development of young orphanage children pot
... The Effects of Early Social-Emotional and Relationship Experience on the Development of Young Orphanage Children St Petersburg © 2009 Blackwell Publishing Ltd ISBN: 978-1-405-19599-7 The Effects ... of Early Social-Emotional and Relationship Experience on the Development of Young Orphanage Children St Petersburg © 2009 Blackwell Publ...
Từ khóa:
- mammalian target of rapamycin mtor
- akt mammalian target of rapamycin mtor
- effects of teaching literature on culture learning in the language classroom
- explain some of the environmental effects of fossil fuel exploration and extraction
- the effects of client management concessions and ingratiation attempts on auditors trust and proposed adjustment
- the effects of gender on communication and workplace relations
- the effects of anticholinergic drugs chlorpromazine and lsd 25 on evoked potentials eeg and behaviour
- the effects of alcohol on reproductive and fetal health
- effects of phospholipid degradation on cholesterol flow in the cell