Demonstration of specific dust mite allergen induced respons

Demonstration of specific dust mite allergen induced response in a murine model

... relevant than ovalbumin which is the standard antigen used in murine models of atopic asthma There is also a lack of animal models using dust mite allergens as the allergen source (Sharma et al., ... these allergens interact in a host system was investigated using responder animals in the context of modeling atopic asthma 3.3 Murine model of dust mite allerg...

Ngày tải lên : 04/10/2015, 10:26

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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt

... to a number of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained ... increase the affinity of the DNase I for DNA, resulting in two improved characteristics – increased specific activity compared to the wild-type enzyme a...

Ngày tải lên : 09/08/2014, 07:20

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An asthma allergen specific animal model for the study of responses to dust mite allergen induced asthma

... in the OVA model of asthma may not be entirely applicable to asthma induced by these allergens Therefore, there is a need for an asthma model based on real aeroallergens There is a lack of tools ... allergic inflammatory response and understanding the nature of these allergens is key to understanding the development of asthma 1.4 Aims of the study Wor...

Ngày tải lên : 15/09/2015, 21:56

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Báo cáo sinh học: "Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" pptx

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên : 18/06/2014, 19:20

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báo cáo hóa học:" Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" doc

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên : 20/06/2014, 03:20

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Báo cáo y học: "Gait analysis in a murine model of collagen-induced arthritis" ppsx

... design, analysis and interpretation of data, and manuscript preparation JV contributed to study design, acquisition of data, analysis and interpretation of data, manuscript preparation, and statistical ... arthritis Arthritis Rheum 2007, 56:1164-1174 Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, et al.: TGF-beta t...

Ngày tải lên : 09/08/2014, 10:22

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Báo cáo y học: " Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma" potx

... et al.: Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma Respiratory Research 2010 11:138 Submit your next manuscript ... function and airway inflammation caused by a potent oxidant like Cl2 is relatively under-investigated Recently a combination of anti-oxidants (ascorbic acid,...

Ngày tải lên : 12/08/2014, 11:22

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Báo cáo y học: " Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation" docx

... smoke-induced airway neutrophilia was attenuated by a dual tachykinin NK1/ NK2 receptor antagonist in guinea pigs [22] The purpose of this study was to characterize the precise role of the tachykinin ... whereby a role for the tachykinin NK1 receptor in macrophage and DCs accumulation was demonstrated The impaired accumulation of these cell types see...

Ngày tải lên : 12/08/2014, 14:20

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Investigation of blast induced neurotrauma in a rodent models

... Overview of Traumatic Brain Injury Traumatic brain injury (TBI) is one of the foremost causes of disability and death in both civilian settings and theatres of war TBI can be simply defined as damage ... 2g Blast (green) and 5g BA (blue) Animals were trained to attain ≥80% baseline accuracy No significant difference was found for both g and g BA from baseline scores and sham anima...

Ngày tải lên : 08/11/2015, 17:00

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Báo cáo sinh học: " Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastase" potx

... 1: faint staining; 2: small amount or weak staining; 3: moderate staining; 4: abundant or strong staining; 5: Abundant or very strong staining Means for each group were determined using the individual ... immediately following ablation Panels f-l are CD3+ stained tumor sections from LA treated animals collected at day post treatment Panels f and g depict CD3+ staining of a vascular la...

Ngày tải lên : 18/06/2014, 19:20

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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot

... murine brain: (1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of ... used as internal control and untreated control animals (n = 10) were analyzed for baseline evaluation of intracerebral cytokine profiles in these mice (2) In the...

Ngày tải lên : 19/06/2014, 22:20

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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx

... appearance of "mature" amyloid plaques [26,30] These plaques contain fibrillar amyloid peptide and as such can be detected by thioflavine, a reagent that stains proteins in beta sheet conformation ... with oligo A or fAβ Characteristic of fibrillar amyloid plaques in both human AD brain and in mouse models of amyloid accumulation is robust association of activated ast...

Ngày tải lên : 19/06/2014, 22:20

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báo cáo hóa học: " Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis" ppt

... this article as: Virgili et al.: Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis Journal of Neuroinflammation 2011 ... by diazoxide treatment We conclude that oral administration of diazoxide constitutes an appropriate therapeutic approach for treating MS and other de...

Ngày tải lên : 19/06/2014, 22:20

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báo cáo hóa học:" Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases" pot

... 1: faint staining; 2: small amount or weak staining; 3: moderate staining; 4: abundant or strong staining; 5: Abundant or very strong staining Means for each group were determined using the individual ... When applied as a minimally invasive technique, thermal ablation has a number of potential advantages including significantly lower morbidity, minimal destruction of normal liver...

Ngày tải lên : 20/06/2014, 03:20

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Báo cáo y học: "Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells" pps

... 5'-GCCTCCAGCATGAAAGTCTC, 3'-TAAAACAGGGTGTCTGGGGA), IL-1β (5'-TGCACGATGCACCTGTACGA, 3'-AGGCCCAAGGCCACAGGTAT), IL-6 (5'-GTTCCTGCAGAAAAAGGCAAAG, 3'-CTGAGGTGCCCATGCTACATTT), matrix metalloproteinase (MMP)-3 ... DHMEQ inhibits TNF-α-induced nuclear translocation of NF-κB, and does not inhibit phosphorylation and degradation of IκB, or a c-Jun N-terminal kinase (JNK) and a caspase...

Ngày tải lên : 09/08/2014, 07:20

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