... significantly to determining folding rates for a given contact order Moreover, for 14 slow -folding proteins with high contact orders (mixed-a/b and b-sheet proteins), the free energy of unfolding can be used ... by protein engineering methods: Evidence for a nucleation– condensation mechanism for protein folding J Mol Biol 254, 260–288 (1995) 72 Z Guo, C L Brooks III, and E M Boczko, Exploring the folding ... thought that the computational protocol for describing protein folding is straightforward Indeed, the folding dynamics is well-described by the classical Newton equations of motion, and folding may...