bioinformatics methods for identifying novel targets

... measures for the four methods All methods had high sensitivity and NPV Sensitivity ranged between 92.3% for the Ramsey method to 97.4% for the Mayfield method NPVs for all methods were greater than 98% ... patients, with the latter identifying 41% more than the former The other two methods produced prevalence rates of 3.6% (Holzer) and 3.3% (Harrington) A comparison among methods shown in Table suggests ... accuracy of four existing methods compared to medical records We showed that the five methods we examined in this study performed very well in sensitivity Holzer and Mayfield methods identified a...

Ngày tải lên: 10/08/2014, 21:24

... of the thesis A survey on computational methods for identifying conserved protein complexes between species: in this survey, computational methods for identifying conserved protein complexes ... on ortholog assignment methods is also presented due to its significance in the computational pipeline for identification of conserved protein complexes A novel method for identifying conserved ... current protein complex detecting methods still cannot undertake this task, we now need an effective method for this purpose There also exist methods specialized for detecting conserved protein...

Ngày tải lên: 01/10/2015, 17:27

... of the thesis A survey on computational methods for identifying conserved protein complexes between species: in this survey, computational methods for identifying conserved protein complexes ... on ortholog assignment methods is also presented due to its significance in the computational pipeline for identification of conserved protein complexes A novel method for identifying conserved ... current protein complex detecting methods still cannot undertake this task, we now need an effective method for this purpose There also exist methods specialized for detecting conserved protein...

Ngày tải lên: 03/10/2015, 21:56

... of the thesis A survey on computational methods for identifying conserved protein complexes between species: in this survey, computational methods for identifying conserved protein complexes ... on ortholog assignment methods is also presented due to its significance in the computational pipeline for identification of conserved protein complexes A novel method for identifying conserved ... current protein complex detecting methods still cannot undertake this task, we now need an effective method for this purpose There also exist methods specialized for detecting conserved protein...

Ngày tải lên: 04/10/2015, 07:57

... goal of this study is to identify novel modulators and targets for AD therapy with the aim of developing novel strategies to prevent disease progression or for use as prophylactics In the first ... Therefore, there is a need for identifying additional pathway regulators for modifying and enhancing the therapeutic efficacy of currently available GSK-3 inhibitors for AD therapeutics In the ... and robustness of the platform Particularly for a multifactorial disease like AD, these platforms provide excellent opportunity to gather high-density biological information related to different...

Ngày tải lên: 09/09/2015, 11:27

... the concept of directed information, a variant of mutual information introduced originally in the 1970s It is shown that directed information can be successfully used for selecting motifs that ... can be performed efficiently for tree-structured Bayesian networks ACKNOWLEDGMENTS We thank the Editor-in-Chief for the opportunity to prepare this special issue, and the staff of Hindawi for their ... outperforms other grammar-based coding methods, such as DNA sequitur, while retaining a two-part code that highlights biologically significant phrases The ability to quantify cost in bits for phrases...

Ngày tải lên: 21/06/2014, 22:20

... parameters βc or βc Before we leave this section, h,n v,n we make two additional remarks Remark As before, (15) is valid for ri + ≤ s∗ (1) ≤ L − rs n and li +1 ≤ s∗ (2) ≤ M − ls For centroid positions ... constant with sn for most possible locations of targets i and j on the image grid, except when either one of the two targets or both are close to the image borders Finally, for i = j, the energy ... according to the signature coefficients, respectively, for targets and The outputs of the two matched filters minus the corresponding energy terms for targets and 2, respectively, are finally added together...

Ngày tải lên: 22/06/2014, 19:20

... beamforming [15], the data-adaptive robust Capon beamforming (RCB) [9, 10], as well as the data-adaptive amplitude and phase estimation (APES) [9, 10] methods have been considered for image formation ... significantly outperform their dataindependent counterparts In this paper, we consider multistatic adaptive microwave imaging (MAMI) methods to form images of the backscattered energy for early breast ... waveform estimate of the backscattered signal (from the fixed location r) for the ith probing signal Repeating the above process for i = through i = K, we obtain the complete set of K waveform...

Ngày tải lên: 22/06/2014, 23:20

... IH: Data mining in bioinformatics using Weka Bioinformatics 2004, 20:2479-2481 Gewehr JE, Szugat M, Zimmer R: BioWeka – extending the Weka framework for bioinformatics Bioinformatics 2007, 23:651-653 ... Harnessing bioinformatics to discover new vaccines Drug Discov Today 2007, 12:389-395 Martin W, Sbai H, De Groot AS: Bioinformatics tools for identifying class I-restricted epitopes Methods 2003, ... Resource: Combining protein data with bioinformatics tools Retrovirology 2005, 2(1):18 Loregian A, Marsden HS, Palu G: Protein-protein interactions as targets for antiviral chemotherapy Rev Med...

Ngày tải lên: 12/08/2014, 23:21

... deoxycholate, 0.1% SDS), incubated at 95°C for minutes, and centrifuged for minutes at 12 K × g Lysate supernatants were quantitated by Bradford assay For Western blotting, equal amounts of protein ... GFP-CLK expression vectors Forty-eight hours posttransfection, cells were treated with (A) 10 μM TG003 or (B) 10 μM chlorhexidine for 4-5 h then fixed and processed for immunofluorescence localization ... drugs on HIV-1 splice site usage was performed as previously described [55] cDNAs were analyzed for changes in splice site usage within the kb, MS RNA class The forward and reverse primers are as...

Ngày tải lên: 13/08/2014, 01:20

... smaller the effect of the final transformation Three methods for identifying differentially expressedgenes In this section, we describe three commonly used methods in analyzing microarray data: ... MA The global error assessment (GEA) model for the selection of differentially expressed genes in microarray data Bioinformatics 2004, doi:10.1093 /bioinformatics/ bth319 Savoie CJ, Aburatani S, ... different statistical methods available for analyzing microarray data and how they differentiate in terms of performance We proposed a criterion (VCR) to assess different statistical methods and developed...

Ngày tải lên: 14/08/2014, 14:21

... the novel methods successfully 21 revealed novel biological and clinical –relevant information in cancers, even from data sets that have received substantial prior analysis Moreover, the novel methods ... By identifying novel clinically-relevant molecular signatures in cancer, our results thus demonstrate that novel approaches to gene expression data can successfully reveal novel biological information ... data (5, 6) 1.3 Methods for microarray Data Analysis With the rapid application of microarray technology and the growth of microarray data in an exponential order, numerous methods for microarray...

Ngày tải lên: 11/09/2015, 09:04

... 46 CHAPTER –DEVELOPMENT OF METHODS OF ANALYSIS 48 2.0 Development of CE Methods for the Determination of Cyanotoxins 48 2.1 CZE and MEKC Methods for Determination of Microcystins ... same water body Several methods have been developed for the determination of cyanotoxins in water, for example, the international organisation for standardisation method for determination of microcystins ... microcystin exposure x List of Tables Table 1 Analytical Methods for Determination of Cyanotoxins Table Analytical Performance of CZE and MEKC Methods ……………………….58 Table 2 Stacking with the Aid...

Ngày tải lên: 11/09/2015, 10:14

... Despite the superior performance of these technologies mentioned above, GaAs MESFET technology remains competitive for various applications Its performance is adequate for many areas, and has ... Techniques and Optimization Method 52 A novel analytical extraction method for extrinsic and intrinsic GaAs MESFET parameters 55 3.4.1 3.4.2 Chapter Novel analytical method 56 ... analytical small signal model extraction approach is subsequently presented For the first time, a novel analytical approach for extracting all the 15 equivalent circuit elements of GaAs MESFET devices...

Ngày tải lên: 11/09/2015, 10:14

... Synthetic Route 183 iii SUMMARY PART I: Development of Novel Methods for the Synthesis of Homoallylic Alcohols In the development of novel methods for the synthesis of homoallylic alcohols, two conceptual ... – C bond formation methods is therefore an utmost task to organic chemists.7 In this aspect, extensive efforts have been devoted to the exploration of chiral reagents and catalysts for the carbonyl-allylation ... would have to await for more complete purification and sensitive methods for structural scrutiny.29 Therefore, the small amount of relatively pure extract that remained was stored for future study...

Ngày tải lên: 16/09/2015, 17:11

... Fourier Transform (STFT) [36, 79], Wigner-Ville Transform [65, 98] and Wavelet Transform (WT) [62] In the STFT transform (which is also called the window Fourier transform or the Gabor transform) the ... 1/α )−αk−2 for < α < for α = for < α < for α = (3.3.2) The density function χα,γ (r) described above is also a heavy-tailed function An expression for the FLOM’s, similar to the one for the single-dimensional ... 2.1.1 Rationale for the Use of Wavelets in Signal Processing 2.1.2 Short-Time Fourier Transform vs Wavelet Transform 2.2 Dyadic Wavelet Transform ...

Ngày tải lên: 13/11/2015, 04:33

... Section presents the general formulation of the problem in the form of a stochastic integral equation, a formal analytical solution and a closure approximation for zero mean forcing function Section ... 10.Appendix: Mathematical Results and Formulae 10.1 MATHEMATICAL PROPERTIES OF VARIATIONAL BIE 10.1.1 Coupling on a Volume 10.2 PROPER NORM FOR RESIDUAL FORCES 10.3 MATRICES FOR THE REFLECTIONTRANSMISSION ... Abstract Introduction Wave Propagation in a Half-Space 2.1 INCIDENT WAVES BEM Formulation for SH Waves BEM Formulation for P, SV and Rayleigh Waves Observed Amplification in the Mexico City Valley...

Ngày tải lên: 17/08/2013, 11:30

... examined flocculating properties in an effort to develop an effective extraction method for bioflocculants from the microbial cell surface Materials and Methods Activated sludge samples Activated ... measured for min, and the relative A660 against the control test was calculated every minute using the following formula: The relative A660 = A660 of flocculating test A660 of control test For the ... effective extraction method for activated sludge However, cell disruption is not effective for the isolation of bioflocculants Thus, NaOH extraction was the most effective method for the extraction of...

Ngày tải lên: 05/09/2013, 09:08

... or for that matter, one “best research design” approach for customer satisfaction measurement In the end, the cost versus the value of the information should dictate CSM form and function for ... Low – medium High High Depends on methods Poor (excluded) Poor – fair (rerouted) Very good Very good Depends on methods Fair Fair Good Excellent Depends on methods Short, 5”-10” Comment questions ... Fair – Poor Very good Excellent Depends on methods Good Good Very good Excellent Depends on methods Lowest Moderate High Highest Blended On review of the information in the table, in-person surveys...

Ngày tải lên: 18/10/2013, 12:15