Chemical biology of matrix metalloproteases

... CHEMICAL BIOLOGY OF MATRIX METALLOPROTEASES Wang Jun Under the supervision of Associate Professor Yao Shao Qin A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF CHEMISTRY ... the facile synthesis of various affinity-based hydroxamate probes that enables the generation of activity-based fingerprints of a variety of metalloproteases, including matr...

Ngày tải lên: 03/10/2015, 20:33

... CHEMICAL BIOLOGY OF METALLOPROTEASES AND CYSTEINE PROTEASES HU MINGYU (B.Sc., SOOCHOW UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY ... activities 1.2 Chemical Biology of Metalloproteases Metalloproteases, together with serine, threonine, cysteine, aspartate and glutamic acid proteases, represent the six major cla...

Ngày tải lên: 09/09/2015, 18:54

... far only appeared as abstracts [21,22], is the targeted disruption of the MMP13 gene The strategy employed involved the deletion of the critical zinc-binding region in the catalytic domain that ... predicted the replacement of a tyrosine by a stop codon (Y2 44X) In another family, there was a missense mutation that predicted the substitution of an arginine by a his...

Ngày tải lên: 09/08/2014, 01:21

... Wee Liang for helping me in the synthesis of the NDA-AD cross-linker, Derek for helping me in the synthesis of the dialdehyde and Liquian and Hongyan for their help in the peptide synthesis - ... expression levels of the proteins, relatively newer approaches such as Activity- Based Protein Profiling (ABPP) provide more insights into the functional states of...

Ngày tải lên: 11/09/2015, 09:58

... Physical & Chemical Characteristics of U.S DDGS Physical and chemical characteristics of distiller’s dried grains with solubles (DDGS) vary among sources and can influence its feeding value and ... size (geometric mean), the coefficient of variation (CV) and 08 - Physical & Chemical Characteristics of DDGS standard deviation (SD) of particle size within...

Ngày tải lên: 08/08/2012, 10:03

... 24 CHEMICAL ANALYSIS OF WATER AND WASTEWATER 24.1 GENERAL ASPECTS OF ENVIRONMENTAL CHEMICAL ANALYSIS Scientists’ understanding of the environment can only ... knowledge of the identities and quantities of pollutants and other chemical species in water, air, soil, and biological systems Therefore, proven, state -of- the-art techniques of chemical analysis,...

Ngày tải lên: 23/07/2013, 20:57

... 2.2.5 Physical and alkaline pretreatment with saccharification Alkaline pretreatment and saccharification was examined by adding 3.3 g of wheat straw in 100 ml monoethanolamine solution in a 200 ... 2, 1.6 g of wheat straw was mixed in 50 ml of sterilized distilled water in 100 ml shaker flask and autoclaved at 135°C for h During Experiment and 4, 1.6 g...

Ngày tải lên: 05/09/2013, 15:28

... for crop improvement Trends Biotechnol 26: 531–537 Chapter Molecular Biology of Secondary Metabolism: Case Study for Glycyrrhiza Plants Hiroaki Hayashi Abstract Licorice (roots and stolons of ... al., 2003) Molecular Biology of Secondary Metabolism 99 the high-level accumulation (more than 2% of dry weight) of soyasaponins (Hayashi et al., 2003) Furthermo...

Ngày tải lên: 25/10/2013, 05:20

... system Biology of Aquatic Organisms Fish anatomy Anatomy of the shark Squalus acanthias Biology of Aquatic Organisms Fish anatomy External morphology - shark • Body regions – head – trunk – tail Biology ... protractor muscles Biology of Aquatic Organisms Fish anatomy 30 Internal morphology - shark • Sensory systems – eye • retina Biology of...

Ngày tải lên: 15/12/2013, 03:15

... αphellandrene and β-phellandrene was 5.73 Table The composition of leaf essential oil of Machilus japonica Siebold & Zucc (Lauraceae) fromVietnam Peak Identification α-Thujene α-Pinene Sabinene KI ... areas [9-12] Results and discussion The essential oil was light yellow and the total yield of 1.23% The chemical composition of the leaf essential oils of...

Ngày tải lên: 12/02/2014, 17:20

... ASTM Annual Book of Standards, Part 31, D3694-78 “Standard Practices for Preparation of Sample Containers and for Preservation of Organic Constituents,” American Society for Testing and Materials, ... present, add 80 mg of sodium thiosulfate per liter of sample and mix well EPA Methods 330.4 and 330.5 may be used for measurement of residual chlorine.9 Field tes...

Ngày tải lên: 14/02/2014, 03:20

... secondary dilution standard be prepared at a concentration of 15 µg/mL of each internal standard compound The addition of 10 µL of this standard to 5.0 mL of sample or calibration standard would be ... the chemical analysis Additional references to laboratory safety are available and have been identified4,6 for the information of the analyst Apparatus and Materials 5.1 S...

Ngày tải lên: 14/02/2014, 03:20

... Organic Electronics Structural and Electronic Properties of OFETs Edited by Christof Wöll WILEY-VCH Verlag GmbH & Co KGaA XLIV List of Contributors Organic Electronics Edited by Christof Wöll ... prediction of the relative positions of electronic levels at metal/molecule interfaces is not straightforward and requires more detailed investigations [29, 30] OFETs and Organ...

Ngày tải lên: 16/02/2014, 19:20

... olfactory and respiratory cilia (see below) Biology of S100–annexin complexes S100–annexin complexes S100A10–annexin A2 complex Distribution The mRNA expression of S100A10 and annexin A2 has been shown ... S100A10–annexin A2 complex (see above) Other S100–annexin complexes Although the number of reports is limited, other S10 0– annexin complexes have been reported: S1...

Ngày tải lên: 18/02/2014, 14:20