Cell based diabetes treatment in a preclinical model

... diabetic monkeys that underwent liver resection and hepatocyte transplantation 50 ix ABBREVIATIONS AAALAC Association for Assessment and Accreditation of Laboratory Animal Care ALT Alanine aminotransferase ... bilirubin, alkaline phosphatase, serum alanine transaminase (ALT) and γ-glutamyl transferase (γGT) activities), renal function (urea and creatinine) and full blood counts (total and dif...

Ngày tải lên: 03/10/2015, 11:36

... this article as: Jones et al.: Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring InsulinLike Growth Factor-1 in a Preclinical Model of Human Breast Cancer ... conditions in the University of Maryland, Baltimore animal facility and maintained in accordance with institutional guidelines approved by the Univ...

Ngày tải lên: 11/08/2014, 00:23

... -response relationships in a human glioma cell line (BMG-1) show that disulphonated aluminum phthalocyanine (AlPcS2) photodynamically induces loss of cell survival (assayed by clonogenicity) in a concentration ... 72:210-216 Gupta S, Dwarakanath BS, Muralidhar K, Jain V: Cellular uptake, localization and photodynamic effects of haematoporphyrin derivative in hum...

Ngày tải lên: 18/06/2014, 16:20

... with an intra-peritoneal injection of 400 mg/kg chloral hydrate (Pharmaceutical Plant of Tiantan Hospital, Beijing, China) The rectal temperature was monitored and maintained at 37.5°C A scalp incision ... infarcted brain parenchyma of transplanted rats (A- iii and A- iv) A comparable extent of class II MHC was noted in ischemic rats irrespective of any therapy but unrema...

Ngày tải lên: 18/06/2014, 16:20

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... crossing; and = many fibres crossing Collagen immunostaining Cryosections were fixed in acetone for procollagen type I, and collagen types I and III staining For collagen type II staining paraffin ... present study shows that enzymatic treatment of cartilage wounds increases histological integration and improves biomechanical bonding strength Enzymatic treatment may re...

Ngày tải lên: 09/08/2014, 01:24

... survival data we also analyzed the animals' clinical status We found that imatinib treatment in both early and late treatment arms also attenuated radiationrelated clinical adverse effects such as ... imatinib treatment starting days and weeks after radiation (RT) Fibrosis is characterized by diffuse bilateral areas of "ground-glass" attenuation and intralobular reticular opac...

Ngày tải lên: 09/08/2014, 10:20

... frequently employ autoantigen microarrays as a screening tool to identify autoantibody reactivities using a multiplex platform and rely heavily on statistical algorithms to determine significant differences ... TLR inhibitors are already being tested in SLE in early-phase human clinical trials Our studies provide a crucial link between the IFN -I system and TLR signaling in...

Ngày tải lên: 09/08/2014, 14:22

... TGF-β1 in the urine of male rats after CYP were also significantly higher than the levels of active and total TGF-β1 in the urine of female rats, both at baseline and after CYP (ANOVA, Tukey post ... control rats collected at the same time point of the day The levels of NO2-/NO3- in the urine of CYP-treated female rats remained higher as compared to both CY...

Ngày tải lên: 11/08/2014, 08:22

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...

Ngày tải lên: 12/08/2014, 14:20

... data confirmed that Wlds reactivates dormant cell cycle pathways, pushing cells toward cell cycle re-entry rather than inhibiting it Role of Pttg1, NAD, and VCP pathways in mediating cell cycle ... SuperArray analysis as being upregulated by more than twofold The final portion of the graph shows similar increases in cell cycle proteins not included on the SuperArray pl...

Ngày tải lên: 14/08/2014, 20:22

... with both the avian and human strains of influenza This facilitates viral reassortment and the generation of novel   10 Chapter 1: Introduction human viral strains with the potential of transferring ... cells HAspecific antibodies form a solid correlate of protection against influenza provided that they match the virus causing the infection In contrast to the antib...

Ngày tải lên: 10/09/2015, 09:25

... resulting in intracellular ionic imbalance and activation of the inflammasome (Ichinohe et al 2010) Although influenza infection results in activation of the inflammasome in both lung stromal and ... ciliated epithelium results in initial shrinkage and vacuolaization of the cells, culminating in necrosis and eventual desquamation of these cells into the luminal space The...

Ngày tải lên: 10/09/2015, 15:53

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... MPTP, an acute insult initiates an inflammatory reaction that becomes self sustaining after the initiating agent has disappeared The MPTP model of...

Ngày tải lên: 11/09/2015, 09:05