Metabonomic study of amyotrophic lateral sclerosis in SOD1G93A mouse model

... however is in agreement in both studies; the decrease of inosine in our study (Table 3) and the decline in the levels of metabolites of xanthine metabolism in the clinical study [80] point to a ... Logroscino, G., et al., Incidence of amyotrophic lateral sclerosis in Europe J Neurol Neurosurg Psychiatry, 2010 81(4): p 385-90 Marin, B., et al., Incidence of amy...

Ngày tải lên: 30/09/2015, 10:12

... play a primary role in the differing toxicity of G93ASOD1 and wtSOD1 As long as GCL activity and GCLM are elevated, as in lowG9 3A- tTA cells, motor neuronal cells maintain some antioxidant capacity ... Our model appears to also provide a tool to investigate the effects of chronic exposure to a small amount of G93ASOD1, as seen in the motor neurons of F...

Ngày tải lên: 29/03/2014, 23:20

... from the AR+ luminal cell population [9] In other words, AR signalling may be entirely bypassed during the transformation of prostate stem cells into PCSCs [9] Alternatively, AR signalling may remain ... basal /stem cells, supporting that they could be the origin of PCSCs under the influence of persistent Hedgehog overexpression P63+ basal /stem cells were transfo...

Ngày tải lên: 10/08/2014, 05:21

... same mouse; and (b) the protein was consistently identified in the independent Fig Evaluation of the isolation of lipid raft proteins Lipid raft proteins were isolated from spinal cords of symptomatic ... Metabolism AATM _MOUSE CHP1 _MOUSE CD81 _MOUSE CDC42 _MOUSE CAH2 _MOUSE DHPR _MOUSE ALDOC _MOUSE LDHB _MOUSE MDHM _MOUSE MBP _MOUSE MYP0 _MOUSE SIRT2 _MOUSE...

Ngày tải lên: 23/03/2014, 04:21

... S phase (Ekholm-Reed et al., 2004) Pin1 regulates the turnover of Cyclin E, where Pin1- /MEF showed higher levels of Cyclin E resulting in the impairment of the progression through the G1-S phase ... to inhibit or increase the activity of Cdc25, which is the activating phosphatase of the Cdc2-Cyclin B complex that is required for the entry into the mitotic phase depending o...

Ngày tải lên: 10/09/2015, 09:29

... length Vgf content in CSF in ALS In A, full-length Vgf was assessed by quantitative ELISA assays; in B, Vgf content decreased as a function of progression of muscle weakness assessed by manual muscle ... Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM A ketogenic diet as a potential novel therapeutic intervention in amyotrophic late...

Ngày tải lên: 03/11/2012, 10:52

Ngày tải lên: 19/06/2014, 22:20

... b-actin ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor-A; CCL2, chemokine ligand- 2; PBMCs, peripheral blood mononuclear cells levels did not vary between definite, ... represented by x-axis in part “A” ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor-A; CCL2, chemokine ligand- 2; PBMCs, per...

Ngày tải lên: 19/06/2014, 22:20

... Rison and Beydoun: Amyotrophic lateral sclerosismotor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature Journal of Medical Case ... Among these patients, few had a beneficial neurological response to immunotherapy, and most died of the neurological disease Other reports highlight...

Ngày tải lên: 11/08/2014, 02:21

... STRUCTURE < /b> AND FUNCTION < /b> STUDIES < /b> OF < /b> VESICLE-< /b> ASSOCIATED < /b> MEMBRANE < /b> PROTEIN < /b> -ASSOCIATED < /b> PROTEIN < /b> B ASSOCIATED < /b> WITH AMYOTROPHIC LATERAL SCLEROSIS Lua Shixiong B. Sc (Hons.), NUS A THESIS SUBMITTED ... VAMP -associated < /b> protein < /b> VAPA /B/ C VAMP -associated < /b> protein < /b> A /B/ C VAPB-2 VAMP -ass...

Ngày tải lên: 12/10/2015, 17:34

... compare the safety and efficacy of three bone health Plans using three independent sequentially enrolled groups of healthy women 40 years of age and older The primary outcome measure was changes in ... reviewed in the meta-analysis cited above As for the unusual finding of the increased BMD levels found in the three study groups, the superiority...

Ngày tải lên: 25/10/2012, 11:10

... an Indian Tribal population Journal of Associated Physician Of India 1986; 34:567-570 Hazarika NC, Biswas D, Mahanta J Hypertension in the elderly population of Assam Journal of Associated Physician ... 42-55% in Indian Mustard Fish oil is the main source of omega-3 fatty acids (EPA- eicosapentaenoic acid and DHA -docosahexaenoic acid) and also omega-6 fatty acids- two main cl...

Ngày tải lên: 02/11/2012, 11:12

... developed in this paper proposes a procedure for integrated and multicriteria evaluation and selection of wastewater treatment scenarios through a case study in Toan Thang, a small town in Vietnam ... Province, Vietnam, Water Supply and Sanitation Programme for Towns in Vietnam, Ministry of Construction, Vietnam (in Vietnamese) Viwase (2007b) Report...

Ngày tải lên: 05/09/2013, 10:15

... Khanaqin Haditha 34 H-1 Hit 160 Km Ramadi Rutbah Baghdad Habbaniyah 33 Karbalaa AL-Hillah Kut AL-Hai Nukhaib Najaf 32 Diwaniya Amarah Semawa Nassriyah 31 Basrah AL-Salman Bussaya Shaibah Fao 30 39 ... same four points as shown in Figure Zakho 37 Rabiah Salahaddin Sinjar Mousl Tallafar Arbil 36 Sulaimaniyah Kirkuk Chamchamal Baiji 35 Tikrit Latitude ( Degree ) Ana Samarra AL-Qaim Khanaqin Ha...

Ngày tải lên: 05/09/2013, 17:03