Effects of apolipoprotein e on n methyl d aspartate receptor signalling the roles of ageing and chicken extract

... 2000) There are 14 Chapter 1: Introduction isoform-specific neurodegeneration and as age-dependent human effects apoE3 of prevents human kainic apoE on acid-induced neurodegeneration in comparison ... regions more intensely than non-carriers and exhibit compensatory neural recruitment (Han and Bondi, 2008) This phenomenon occurs even in non-demented older adults suggesting ε4 carr...

Ngày tải lên: 30/09/2015, 06:42

... observed in H2S- and NMDA -mediated 59 neuronal death 3.3 Global gene profiles of H2S- and NMDA -mediated neuronal 61 deaths 3.3.1 Differential gene expression of genes encoding proteins 64 involved ... subunit beta (Psmb2) 120 Role of the AVD in cell death and its relevance in H2S- 121 mediated neuronal death 4.2 Proposed signaling cascade of H2S -mediated signaling casca...

Ngày tải lên: 10/11/2015, 12:35

... also examined the changes of gene expressions of CAT, SOD1, SOD2 and GPx in both young (PDL20 -30 ) and old (PDL >45 ) HDF after 24 hours of treatment with EGCG, since these enzymes are mostly influenced ... expressions both in the young and the old HDF In the young HDF, the gene expressions of CAT, SOD1, SOD2 and GPx increased in response to 25 μM 87 EGCG by 94. 1, 6...

Ngày tải lên: 11/09/2015, 16:05

... listed in Table S cerevisiae C elegans D melanogaster M musculus lag1 daf -2 sod1 prop -1 lac1 age -1/ daf- 23 cat1 p66shc ras2 akt -1/ akt -2 ras1 phb1 daf -16 daf -18 phb2 daf - 12 mth cdc7 ctl -1 mclk1 bud1 ... significant 3. 2 Part two: Effects of epigallocatechin- 3- gallate on mitochondrial integrity and antioxidative enzyme activity in aging process of h...

Ngày tải lên: 11/09/2015, 16:05

... cellular aging studies [16 0, 16 1] The LC50 value of EGCG and its anti- and pro-oxidant effects are examined initially Then in the short term study, HDF is exposed to H2O2 induced oxidative stress and ... 6.25, 12 .5, 25, 50 and 10 0 μM were added into the MEM For the first 30 min, 10 0 μM of EGCG cleared about 32 % free radicals of DPPH but its radical scavenging act...

Ngày tải lên: 11/09/2015, 16:05

... 61 3. 3 .10 Antioxidative enzyme activities .62 3. 3 .11 Antioxidative enzyme gene expressions 62 3. 3 .12 Microarray and data analysis 63 3 .3. 13 Statistics 64 Main results ... activity in Fischer 34 4 rats; Mechanisms of Ageing and Development, 12 8 (3) :286-92 II Meng Q, Velalar CN and Ruan R, (2008); Effects of epigallocatechin- 3- gallate on mitoc...

Ngày tải lên: 11/09/2015, 16:05

... process of HDF reaching the end point, samples were collected, and intracellular ROS accumulation, mitochondrial integrity, antioxidative enzyme activities and gene expressions were examined and ... Effects of EGCG in long term treatment In the long term treatment, the middle-aged HDF (PDL 35) was continuously cultured in MEM with 12 .5 μM of EGCG until they reach...

Ngày tải lên: 11/09/2015, 16:05

... ILMN _6 63 7 5a ILMN_55276e ILMN_5 432 7e ILMN _61 732 e ILMN _65 726e ILMN_49450a ILMN_52 1 36 e ILMN_57 63 0 a ILMN _6 539 0c ILMN_ 537 85e ILMN _64 064 e ILMN_5 268 6c ILMN _6 737 3c ILMN_58243e ILMN _6 63 8 2e ILMN_51 069 e ILMN_59474e ... 2.007 1. 962 1.9 46 1.944 1.9 16 1. 864 1.815 1.784 1 .69 8 1 .68 9 1 .67 5 1 .66 6 1 .66 2 1 .64 5 1. 63 7 1. 63 0 1.577 1. 567 1.558 1.554 1.54...

Ngày tải lên: 11/09/2015, 16:05

... Neurobiology of Aging 22 (2001) 683– 689 Table Relationship of Time of Follow-up and APOE-␧4 to Memory, Visuospatial and Language Performance in Healthy Elderly Over years* Variable Memory Factor Time Time*APOE-␧4Š ... differences in the slope of performance over time There was no statistically significant difference at a particular interval In this study me...

Ngày tải lên: 05/03/2014, 21:20

... et al.: The differential mediating effects of pain and depression on the physical and mental dimension of quality of life in Hong Kong Chinese adults Health and Quality of Life Outcomes 2010 8:1 ... mediation is established if the association between depression and QoL is reduced to zero The Sobel test [24] determined whether pain...

Ngày tải lên: 18/06/2014, 19:20

... the effects of stranded oil on tidal flat ecosystems with special emphasis on the relationship between seawater infiltration and macrobenthic community using tidal flat ecosystem simulators TIDAL ... at day 23 and 58 in the C and O simulators Fig.8 shows infiltration rate of seawater by tidal action both in the C and O simulators The infiltration...

Ngày tải lên: 05/09/2013, 08:40

... as a model Tables 10: The reasons for the approval the application of giving a text as a model in the future Table 11: The reasons for the disapproval of application of giving a text as a model ... languages department An investigation into the effects of brainstorming and giving a text as model on phan dinh phu...

Ngày tải lên: 18/12/2013, 10:08

... indication of the effects of education and health on labour productivity In the case of education, it is likely that on average across the community, the effect of a person’s level of education on their ... to the effects of education (section 2.1) and health (section 2.2) on wages 2.1 Education and wages The influence of educati...

Ngày tải lên: 14/02/2014, 09:20

... properties of CDase I-5 was examined at various concentrations of KCl First, the role of KCl in dissociation of CDase I-5 was investigated by analytical ultracentrifugation As the KCl concentration was ... calculating the peak area during the dissociation process The rate of change in the peak area shown in Fig 3A was estimated according to an equation of single e...

Ngày tải lên: 07/03/2014, 12:20