Activities of the cytokine receptor CD137 in multiple myeloma

... Bidirectional Signalling of the CD137: CD137L System 16 1.9 CD137/ CD137L in Tumor Immunotherapy 19 1.10 Multiple Myeloma and the CD137: CD137L System 23 1.11 Multiple Myeloma and Follicular ... rendering it obsolete Published by the International Myeloma Working Group in 2005, the International Staging System (ISS) for multiple myeloma relies mainly on the de...

Ngày tải lên: 26/09/2015, 10:59

... from synovia from OA and RA patients Discussion The novel finding of the present study is the identification of the key components of the cannabinoid receptor system in the knee synovia of patients ... levels of PEA were similar in the synovial fluid of OA and RA patients Thus, levels in the synovial fluid not simply reflect the leve...

Ngày tải lên: 09/08/2014, 10:23

... nuclear receptors The androgen receptor The polymorphic region of CAG repeats in the androgen receptor gene CHAPTER 1: CAG REPEAT POLYMORPHISM IN THE 17 ANDROGEN RECEPTOR GENE AND MALE INFERTILITY INTRODUCTION ... TRINUCLEOTIDE (CAG) REPEAT POLYMORPHISMS OF THE ANDROGEN RECEPTOR GENE IN HUMAN DISEASE AMPARO MIFSUD GINER (B Science (Hon...

Ngày tải lên: 11/09/2015, 09:05

... W.V., Estrogenic pesticides: Binding relative to estradiol in MCF-7 cells Additive Estrogenic Activities of the Binary Mixtures of Four Estrogenic Chemicals in Recombinant Yeast Expressing Human Estrogen ... than the sum of the parts, these effects are not synergistic Also, additive effect was observed with the combinations of Additive Estr...

Ngày tải lên: 07/08/2014, 15:20

... questions The final aim of the research is to investigate the techniques to overcome the factors that may have negative effects on the participation in classroom oral activities of the second year Tourism ... on the students involvement and analyze the techniques and activities the teachers of English at the Tourism Faculty in CS...

Ngày tải lên: 29/01/2014, 14:35

... C An et al Manduca sexta Spatzle ¨ Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function ... gene In the clade including Spatzle- 1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing...

Ngày tải lên: 06/03/2014, 09:22

... contained a truncated core OS and consisted of a linker (Glc-Kdo2)-lipid A structure The phenotype of this mutant was examined to investigate the roles of different moieties of the LOS molecule in ... chain moiety of the M catarrhalis LOS is important in biological activities such as serum resistance and adherence of epithelial cells, the linker moiety is...

Ngày tải lên: 07/03/2014, 05:20

... together, we suggest the biological relevance of our findings as follows The binding of AVP to V2 receptors on the renal collecting duct principal cells stimulates cAMP-dependent translocation of ... in the principal cells, it is also known that V2 receptors are expressed in the basolateral plasma membranes These results indicate that the binding of the hor...

Ngày tải lên: 08/03/2014, 02:20

... 3 1 1 1 1 )4 71, +467 )4 71 )4 71, )1 16 )3 96 )3 48 )3 48 )3 18, +109, +201 )2 67 )2 19, )1 38, +206 )1 53 )5 3 )5 2 )5 2 +222 +260 +423 +465 +466 a Numbers refer to the position of the 5¢-end of the conserved ... throughout the brain tissue in R6/1 compared to R6/2 mice [29,30] The differences between the two transgenic line...

Ngày tải lên: 16/03/2014, 18:20

... subdomain AR3)13 in N/C interaction and the role of individual amino acid residues in and flanking the 23 FQNLF2 7motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated that AR3)13 ... E., Brinkmann, A.O & Trapman, J (1997) Functional in vivo interaction between the amino- terminal, transactivation domain and the ligand bind...

Ngày tải lên: 17/03/2014, 10:20

... FNIII domains of gp130 are therefore assumed to be arranged in such a way that the C-terminal parts of the membrane-proximal domain D6 are positioned in close vicinity to each other In analogy, ... correct spacing and orientation of the cytoplasmic parts of the receptors for signalling An exchange of gp130 D6 with a domain that does not allow interactions...

Ngày tải lên: 18/03/2014, 01:20

... FkpA [11], these proteins are composed of N- and C-domains, which are spanned by a 40 amino acid long a3 helix The N-domain consists of a1 and a2 helices and an N-terminal region of a3 helix The ... FKBP22 variants containing either one of these domains and compare their activities and stabilities with those of the intact protein In this report, the...

Ngày tải lên: 23/03/2014, 13:20

... representing the strongest effect on the 11bhydroxylation activity of all single mutants investigated here When both mutations were introduced into CYP11B2, the 11b-hydroxylation capacity was additionally ... strongly improve the substrate conversion in relation to the CYP11B2 wild-type protein (Fig 3) By replacing the amino acids in positions 112 and 147 of CYP1...

Ngày tải lên: 24/03/2014, 03:21

... cyclooxygenase pathway PGE2 is the major prostanoid synthesized by lung fibroblasts [11] It can also act on fibroblasts in a paracrine fashion after release from the adjacent epithelial layer [12] In addition ... differential modulation of the translation rate or the rate of internalization and degradation of PAR-1 protein As we and others [15–17,26,33] h...

Ngày tải lên: 30/03/2014, 04:20

... al.: Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins Journal of Translational Medicine 2011 9:2 Submit your next ... to tumor induced by E6/E7 oncoproteins and human SCLC In particular, the Aryl Hydrocarbon receptor signaling is the predominant pathway dere...

Ngày tải lên: 18/06/2014, 16:20