Novel chiral stationary phase for the enantioseparation of racemic drugs 1

... Experimental 13 9 7 .1 General 14 0 7 .1. 1 Materials 14 0 7 .1. 2 Instrumentation 14 0 7 .1. 3 Packing of CSPs 14 1 7 .1. 4 HPLC Instrumentation 14 1 7 .1. 5 Basic Chromatography Parameters 14 2 7.2 Preparation of Ether-linkage ... Conclusion 10 3 References 10 5 Chapter Effects of Spacer Length 10 6 iv 5 .1 Introduction 10 7 5.2 Normal Phase 10 9 5.3 Reversed Phase...

Ngày tải lên: 16/09/2015, 17:13

... 1 .22 1 .24 1. 12 1.33 1.56 0.93 3C6C11C- 2. 58 4 .21 1.46 3.63 5.83 1.75 1.40 1.44 1 .20 2. 17 2. 25 1.13 3C6C11C- 6.50 9.57 4.18 8 .29 12. 45 5.31 1 .28 1.30 1 .27 1.68 1.71 1.70 3C6C11C- 3. 92 5.83 2. 35 ... 13.08 27 .69 8.79 1.44 1.53 1.30 3 .26 2. 69 1.81 3C6C11C- 2. 42 4.50 1.50 1.53 1.57 1 .29 2. 80 2. 46 1.05 3C6C11C- 16.50 28 .00 9.67 21 .50 34 .22 11.33 1.30 1. 72 1.1...

Ngày tải lên: 16/09/2015, 17:14

... DEVELOPMENT OF NOVEL CHIRAL STATIONARY PHASES FOR HPLC BASED ON COVALENTLY BONDED POLYSACCHARIDE DERIVATIVES ZHANG SHENG (B.Sc., Peking University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... chloroform-containing, dichloromethane-containing, tetrahydrofurancontaining mobile phases, as well as standard IPA-hexane mobile phases vii List of Tables Table...

Ngày tải lên: 14/09/2015, 08:40

... Evaluation of New Anti-cancer Nitrogen-Containing Combretastatins and Novel Cysteine Protease Inhibitors for the Treatment of Chagas Rogelio Siles Mentor: Kevin G Pinney, Ph.D In an effort to combat ... Derivatives of Combretastatins A-1 and A-4 66 Synthesis of Cold Precursors of Radio-labeled Combretastatins CA-1 and CA-4 70 Synthesis of OXi800...

Ngày tải lên: 14/11/2014, 11:32

... LIQUID- PHASE MICROEXTRACTION FOR THE DETERMINATION OF ACIDIC DRUGS AND β -BLOCKERS IN WATER SAMPLES EE KIM HUEY (B.Sc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE ... thanks to Xiaofeng for her insight to the project; Junie for proofreading this thesis; Elaine and Debbie for their friendship during the course of this pro...

Ngày tải lên: 10/11/2015, 11:00

... study Ann Oncol 2 010 , 21 : 1877 -18 83 Page of doi :10 .11 86 /17 56 -99 66-30 -16 Cite this article as: Pisani et al.: FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90 yttrium ibritumomab ... ibritumomab tiuxetan consolidation for the treatment of relapsed grades and follicular lymphoma: a report of cases Journal...

Ngày tải lên: 10/08/2014, 10:21

... demonstrated that the established FQ -PCR assay is of highly specific The intra -assay and inter -assay CV of this established FQPCR was in the range of 1–3% for most of the dynamic range (from 1.0 × 109 ... TaqMan real-time PCR method Results Development and optimization of FQ -PCR and conventional PCR Following the optimization of FQ -PCR, final concent...

Ngày tải lên: 12/08/2014, 04:21

... demonstrated that the established FQ -PCR assay is of highly specific The intra -assay and inter -assay CV of this established FQPCR was in the range of 1–3% for most of the dynamic range (from 1.0 × 109 ... TaqMan real-time PCR method Results Development and optimization of FQ -PCR and conventional PCR Following the optimization of FQ -PCR, final concent...

Ngày tải lên: 12/08/2014, 04:21

... influence of changing pH of the buffer and mobile phase composition on enantioseparation of several racemic drugs and compounds viii were also examined using a permethylated CD CSP based on the chiral ... toluene / ∆ Scheme 35 1.12 Racemic Drugs and Compounds The chief aim in this thesis, after the synthesis of the novel CSPs, is targeted towards the enantioseparation o...

Ngày tải lên: 12/09/2015, 10:17

... ease of modifying the potential landscape In fact, the optical potential is formed by the interaction between a laser and the cold gas, and the potential can be tuned by adjusting the shape of the ... and the optical trap [Ashkin et al., 19 86] The optical trap is normally used at the later stage of the experiment due to its ability to trap the atoms...

Ngày tải lên: 30/09/2015, 10:13

... NOVEL CHIRAL STATIONARY PHASES (CSP) FOR ENANTIOSEPARATION PROCESSES CHEN LEI (MSc) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHYLOSORPHY DEPARTMENT ... chromatographic techniques Enantioseparation by HPLC includes two major parts: chiral stationary phases (CSPs) and chiral mobile phase additives (CMPAs) 1.3.1 Chiral stationary phases (CSPs) Chiral H...

Ngày tải lên: 17/09/2015, 17:18

... low back pain Pain Physician 1999;2:59-64 Manchikanti L, Pampati V, Fellows B, et al The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents ... men; mean age 64, range 22-89) were included Length of follow-up was at least years with a maximum of years Location of facet pain was cervical in 45, thoracic in 15, and lu...

Ngày tải lên: 26/10/2012, 09:32

... metacleavage pathway of 2-aminophenol in Pseudomonas sp strain AP-3 (A) Proposed pathway of 4-amino-3-hydroxybenzoic acid in Bordetella sp strain 10d (10) I, 4-amino-3hydroxybenzoic acid; II, 2-amino-5carboxymuconic ... of a mutant, strain Y-2, of the aniline-assimilating Pseudomonas sp strain AW-2 [20] Results Spectral changes during metabolism of 4-amino...

Ngày tải lên: 19/02/2014, 16:20

... paper mill, there is a large steam and electricity demand at the pulp mill To simplify calculations, we decided to use only a pulp mill rather than an integrated pulp and paper mill As a result, the ... From the calculations derived in Appendix A, the energy demand for the modified pulping section of the plant is 56 MW of electricity and 267 tonnes per day...

Ngày tải lên: 26/02/2014, 14:20

... of glutathione and glutathione disulde in human plasma and tobacco leaves by capillary electrophoresis with laser-induced uorescence detection Talanta 65, 986990 Svardal AM, Mansoor MA & Ueland ... curve and the regression equation The average recovery test was made using the standard addition method, and the RSD was generally good when obtained from a series of six plasma s...

Ngày tải lên: 07/03/2014, 05:20